摘要:
A product having a microneedle array is provided wherein the composition distribution has been adjusted with good accuracy. A droplet-delivery apparatus (10) of a microneedle-array manufacturing apparatus (1) is configured capable of delivering, to each recessed part, droplets of a raw-material liquid in a prescribed amount that is less than the capacity of the recessed part. An aligning apparatus (20) can align the relative position of the droplet-delivery apparatus (10) and a mold (80) such that the droplets from the droplet-delivery apparatus (10) are caused to land in each of the recessed parts. The droplet-delivery apparatus (10) delivers a plurality of the droplets to each of the recessed parts; and the aligning apparatus aligns the relative position of the droplet-delivery apparatus and the mold such that a second droplet lands in each of the recessed parts on the center part side of a first droplet.
摘要:
A low cost transdermal patch, which comprises water soluble microneedles and has good performance, and a method of manufacturing the same are provided. A transdermal patch (1 E) comprises a microneedle sheet (310), which comprises a plurality of water soluble microneedles (311), moisture permeable sheet (320), wherethrough water vapor passes, and a reinforcing film (30E). The reinforcing film (30E) is adhered, by an adhesive layer (35) having an adhesive strength less than that of an adhesive layer (322), onto an outer surface (320b) of the moisture permeable sheet (320), which is the side opposite the skin opposing surface (320a). The reinforcing film (30E) includes a water vapor barrier sheet (31), which blocks the passage of water vapor through at least a first area (Ar1), and a removable portion (32) around the water vapor barrier sheet (31). The removable portion (32) is configures such that it can be separated from and peeled off the water vapor barrier sheet (31).
摘要:
A thin film formation apparatus comprises a printing roll 3 having an elastic letterpress 31 of resin or rubber fitted at a part of a surface of a cylinder part 30 and, an intaglio roll 4 rotating while being faced to the printing roll 3 thereby transferring ink to a surface of the elastic letter-press 31 through touch with the printing roll 3. The thin film formation apparatus further comprises a pair of printing roll side contact bodies 300 on a drum portion or a rotating shaft of the printing roll, and a pair of intaglio roll side contact bodies 400 on a drum portion or a rotating shaft of the intaglio roll, the printing roll side contact bodies 300 and the intaglio roll side contact bodies 400 continuing to contact with each other at least before and during the contact of the elastic letterpress 31 with the intaglio roll 4 to form a thin film of uniform film thickness.
摘要:
A conical-projections-sheet packaging body (1) includes a conical-projections sheet (23), a conical-projections forming sheet (7), and a sealing sheet (9). The conical-projections sheet (23) includes a substrate (23a) and a plurality of conical projections (23b) formed on a surface (23c) of the substrate (23a). The conical-projections forming sheet (7) has a plurality of conical-recess parts (33a), which is used to form the plurality of conical projections (23b) and wherein the plurality of conical projections (23b) is disposed. The conical-projections forming sheet (7) protects the conical projections (23b) in a state wherein the plurality of conical projections (23b) is tightly adhered to the surface (23c) of the substrate (23a). The sealing sheet (9), by being fixed to the conical-projections forming sheet (7), seals the conical-projections sheet (23) between the conical-projections forming sheet (7) and the sealing sheet (9).
摘要:
To protect a plurality of conical projections of a conical-projections sheet. A method of manufacturing a conical-projections-sheet packaging body 1 including: a step of forming a plurality of conical-recess parts 34b on a conical-projections forming sheet 34; a step of forming, by supplying a conical-projections material to the conical-projections forming sheet 34, a conical-projections sheet 23 including a base sheet 23a and a plurality of conical projections 23b formed on a surface of the base sheet 23a and disposed inside the plurality of conical-recess parts 34b; a step of forming a plurality of sets of the conical-projections forming sheets 34 and the conical-projections sheets 23 by punching out the conical-projections forming sheets 34 and the conical-projections sheets 23; and a step of using a package member 5 to package a set of the conical-projections sheets 23 and the conical-projections forming sheets 34 tightly adhered to one another.
摘要:
A microneedle patch with which a treatment is reliably completed in a short time when a microneedle is administered into skin or mucous membrane is provided. A microneedle patch (100F) includes a base member (101) and a plurality of microneedles (103g) supported by the base member (101). Each microneedle (103g) includes a top-section layer (104) comprising a biologically active substance to be inserted in dermis (310), and an intermediate layer (106) provided between the top-section layer (104) and the base member (101), having a composition having breaking strength weaker than breaking strength of a composition of the top-section layer (104), and having a thickness of 5 µm and 100 µm inclusive.