公开(公告)号：EP0859956A1

公开(公告)日：1998-08-26

申请号：EP96932488.0

申请日：1996-09-10

申请人： Novartis AG

发明人： CHENE, Patrick ,  HOCHKEPPEL, Heinz-Kurt

IPC分类号： C12Q1 ,  G01N33

CPC分类号： G01N33/53 ,  G01N33/5011

摘要： The present invention concerns a new assay which allows the identification of compounds which inhibit the formation of complexes between a product of the double minute 2 gene ('dm2') and p53 but not between p53 and DNA. Both the complex formation of labeled DNA, C-terminally truncated p53 and dm2 and disruption of dm2 from the labeled DNA-p53 complex by an inhibitor of an p53-dm2 interaction can be detected by a gel shift assay procedure. This assay permits the selection of compounds which, besides their inhibitory property, do not alter p53 specific DNA binding and do not disturb p53 conformation required for DNA binding or formation of active tetramer.

公开(公告)号：EP4395828A1

公开(公告)日：2024-07-10

申请号：EP22797110.8

申请日：2022-08-30

申请人： Novartis AG

发明人： CHAPEAU, Emilie ,  CHENE, Patrick ,  FURET, Pascal ,  KIEFFER, Laurence ,  MACHAUER, Rainer ,  PICARD, Anne ,  SCHMELZLE, Tobias ,  SELLNER, Holger ,  SOLDERMANN, Nicolas ,  VOEGTLE, Markus ,  WARTMANN, Markus

IPC分类号： A61K47/54 ,  A61K47/55 ,  A61P35/00

CPC分类号： A61K47/545 ,  A61K47/55 ,  A61P35/00 ,  C07D405/12 ,  C07D417/12 ,  C07D405/14

公开(公告)号：EP2209529A2

公开(公告)日：2010-07-28

申请号：EP08836801.4

申请日：2008-10-10

申请人： Novartis AG

发明人： CHENE, Patrick ,  GARCIA-ECHEVERRIA, Carlos ,  JENSEN, Michael Rugaard ,  QUADT, Cornelia ,  RADIMERSKI, Thomas ,  SCHOEPFER, Joseph

IPC分类号： A61P35/00 ,  A61K31/5377

CPC分类号： A61K31/5377

摘要： The use of 5-(2,4-Dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4-ylmethyl-phenyl)-isoxazole-3-carboxylic acid ethylamide or a tautomer thereof or a pharmaceutically acceptable salt or a hydrate or a solvate for the treatment of cancer of the bladder, the colon, the liver, the lung,the breast, the ovaries, the pancreas, the kidney, the stomach, the gastrointestinal tract, the prostate, the head and neck, the brain, and/or the blood

公开(公告)号：EP1968964A1

公开(公告)日：2008-09-17

申请号：EP07702563.3

申请日：2007-01-02

申请人： Novartis AG

发明人： AUBERSON, Yves ,  BERGSTROEM, Mats ,  BRIARD, Emmanuelle ,  CHENE, Patrick ,  MARTARELLO, Laurent ,  SCHOEPFER, Joseph

IPC分类号： C07D313/00 ,  C07D493/04 ,  A61K51/04 ,  G01N33/60

CPC分类号： C07D313/00 ,  A61K51/0412 ,  A61K51/0414 ,  C07D493/04 ,  G01N33/574

摘要： The present invention relates to novel radicicol derivatives of the formula (I), in which R is R', (CH3)nCOOR' or (CH2)nCONHR, wherein R' is 11CH3, [3H]3C, [3H]2HC, [3H]H2C or (CH2)nHal, wherein Hal is 123I, 125I, 131I, I, 75Br, 76Br, 77Br, 82Br, Br, 18F or F, or R' is (CH2)n-1[3H]HCHal or (CH2)n-1[3H]2CHaI, wherein Hal is I, Br or F, and n is, each independently, 1 , 2, 3 or 4, in free form or in salt form, to their preparation, to their use as radiotracers/markers and to compositions containing them.

公开(公告)号：EP1734968A2

公开(公告)日：2006-12-27

申请号：EP05751682.5

申请日：2005-04-04

申请人： Novartis AG ,  NOVARTIS-PHARMA GMBH

发明人： BAENTELI, Rolf ,  CHENE, Patrick ,  COLLINGWOOD, Stephen P., Novartis Horsham Res. Ctr ,  FURET, Pascal ,  MEIER, Peter ,  SCHOEPFER, Joseph

IPC分类号： A61K31/52 ,  C07D473/16

CPC分类号： C07D239/48 ,  A61K31/52 ,  C07D473/16

摘要： The invention relates to the use of 9H-purine-2,6-diamine compounds and salts thereof in the treatment of proliferative diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases, pharmaceutical preparations comprising 9H­purine-2,6-diamine compounds, novel 9H-purine-2,6-diamine compounds, and a process for the preparation of the novel 9H-purine-2,6-diamine compounds.

公开(公告)号：EP4121421A1

公开(公告)日：2023-01-25

申请号：EP21712240.7

申请日：2021-03-15

申请人： Novartis AG

发明人： BORDAS, Vincent ,  BROCKLEHURST, Cara ,  CHENE, Patrick ,  FEI, Zhongbo ,  FURET, Pascal ,  GUAGNANO, Vito ,  IMBACH-WEESE, Patricia ,  KALLEN, Joerg ,  LE DOUGET, Mickael ,  LI, Jialiang ,  LI, Wei ,  LORTHIOIS, Edwige Liliane Jeanne ,  MCKENNA, Joseph ,  SALEM, Bahaa ,  SCHMELZLE, Tobias ,  SELLNER, Holger ,  SOLDERMANN, Nicolas ,  VOEGTLE, Markus ,  WARTMANN, Markus

IPC分类号： C07D307/81 ,  C07D401/14 ,  C07D403/04 ,  C07D405/04 ,  C07D405/10 ,  C07D405/12 ,  C07D405/14 ,  C07D407/04 ,  C07D407/12 ,  C07D413/04 ,  C07D417/04 ,  C07D491/04 ,  A61P35/00 ,  A61K31/343 ,  A61K31/443

公开(公告)号：EP1776110A1

公开(公告)日：2007-04-25

申请号：EP05775880.7

申请日：2005-07-26

申请人： Novartis AG ,  NOVARTIS-PHARMA GMBH

发明人： CHENE, Patrick ,  FLOERSHEIMER, Andreas ,  FURET, Pascal ,  SCHOEPFER, Joseph

IPC分类号： A61K31/4184 ,  C07D239/70 ,  A61P35/00 ,  A61P35/02

CPC分类号： A61K31/4184 ,  C07D235/26

摘要： The invention relates to the use of benzoimidazolone compounds and salts thereof in the treatment of proliferative diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases, pharmaceutical preparations comprising benzoimidazolone compounds, novel benzoimidazolone compounds, and a process for the preparation of the novel benzoimidazolone compounds.

公开(公告)号：EP1773327A1

公开(公告)日：2007-04-18

申请号：EP05772457.7

申请日：2005-07-26

申请人： Novartis AG ,  NOVARTIS-PHARMA GMBH

发明人： CHENE, Patrick ,  FLOERSHEIMER, Andreas ,  FURET, Pascal ,  SCHOEPFER, Joseph

IPC分类号： A61K31/416 ,  C07D231/56 ,  A61P35/00 ,  A61P35/02

CPC分类号： A61K31/416 ,  C07D231/56

摘要： The invention relates to the use of 1H-indazol-6-ol compounds and salts thereof in the treatment of proliferative diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases, pharmaceutical preparations comprising 1H-indazol-6-ol compounds, novel 1H-indazol-6-ol compounds, and a process for the preparation of the novel 1H-indazol-6-ol compounds.

公开(公告)号：EP0958305A2

公开(公告)日：1999-11-24

申请号：EP97935511.0

申请日：1997-07-04

申请人： Novartis AG ,  CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED

发明人： LANE, David ,  BÖTTGER, Volker ,  BÖTTGER, Angelika ,  PICKSLEY, Stephen ,  HOCHKEPPEL, Heinz-Kurt ,  GARCIA-ECHEVERRIA, Carlos ,  CHENE, Patrick ,  FURET, Pascal

IPC分类号： G01N33 ,  A61K38 ,  A61K45 ,  A61P35 ,  C07K7 ,  C07K14 ,  C12N15 ,  C12Q1

CPC分类号： C07K7/04 ,  A61K38/00 ,  C07K2319/00

摘要： The present invention relates to compounds capable of binding to the oncogene protein MDM2, processes for the preparation of such compounds, pharmaceutical preparations comprising such compounds, and uses of said compounds, e.g. in the therapeutic (including prophylactic) treatment of an animal or especially of the human body. The present further relates to methods of and compounds for inhibiting the growth of tumor cells which comprise the wild type p53 suppressor by interfering with the interaction between human p53 and human MDM2.