公开(公告)号：EP3615080A1

公开(公告)日：2020-03-04

申请号：EP18724677.2

申请日：2018-04-26

申请人： Novartis AG ,  Aduro Biotech, Inc. ,  Dubensky, Thomas W., Jr.

发明人： DUBENSKY, Thomas W. Jr. ,  BRUML, Jacob, Robert ,  CANHAM, Stephen ,  CHO, Charles, Y. ,  GAUTHIER, Kelsey ,  GLICKMAN, Laura, Hix ,  HAO, Xueshi ,  KANNE, David ,  KASIBHATLA, Shailaja ,  KATIBAH, George, Edwin ,  LE, Thanh Ngoc, Lan ,  LEONG, Justin ,  MCKENNA, Jeffrey ,  MCWHIRTER, Sarah ,  NDUBAKU, Chudi Obioma ,  OU, Weijia ,  SUNG, Leonard ,  TRIA, George, Scott ,  UNO, Tetsuo ,  WU, Tom, Yao-hsiang ,  WAN, Yongqin ,  DUBENSKY, Thomas W. Jr.

IPC分类号： A61K47/68 ,  C07H21/00 ,  A61P33/00

公开(公告)号：EP2531498A1

公开(公告)日：2012-12-12

申请号：EP11703560.0

申请日：2011-02-04

申请人： IRM LLC ,  Novartis AG

发明人： TELLEW, John E. ,  PAN, Shifeng ,  WAN, Yongqin ,  XIE, Yongping ,  WANG, Xing ,  WANG, Xia ,  HUANG, Shenlin ,  LIU, Zuosheng ,  ZHANG, Qiong

IPC分类号： C07D401/14 ,  C07D471/04 ,  A61K31/4353 ,  A61P35/00

CPC分类号： C07D471/04 ,  A61K31/444 ,  A61K31/506 ,  A61K31/519 ,  A61K45/06 ,  C07D401/14

摘要： The invention provides a novel class of compounds of Formula (I) (wherein A, Y, R
2 , R
3 , R
4 and R
5 are defined in the summary of the invention), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.

公开(公告)号：EP3524604A1

公开(公告)日：2019-08-14

申请号：EP19164770.0

申请日：2009-10-29

申请人： Novartis AG ,  The Scripps Research Institute

发明人： BOITANO, Anthony ,  COOKE, Michael ,  PAN, Shifeng ,  SCHULTZ, Peter G. ,  TELLEW, John ,  WAN, Yongqin ,  WANG, Xing

IPC分类号： C07D473/34 ,  C07D487/04 ,  A61K35/28 ,  C12N5/0789 ,  A61P7/00 ,  A61P43/00 ,  A61P35/00 ,  A61K31/52 ,  A61K31/519 ,  A61P37/00

摘要： The present invention relates to compounds and compositions for expanding the number of CD34+ cells for transplantation. The invention further relates to a cell population comprising expanded hematopoietic stem cells (HSCs) and its use in autologous or allogeneic transplantation for the treatment of patients with inherited immunodeficient and autoimmune diseases and diverse hematopoietic disorders to reconstitute the hematopoietic cell lineages and immune system defense.

公开(公告)号：EP3082877A2

公开(公告)日：2016-10-26

申请号：EP14835606.6

申请日：2014-12-17

申请人： Novartis AG

发明人： GEIERSTANGER, Bernhard ,  GRUNEWALD, Jan ,  OU, Weijia ,  UNO, Tetsuo ,  WAN, Yongqin ,  WANG, Xing ,  JIN, Yunho

IPC分类号： A61K47/48 ,  C07K5/02

CPC分类号： C07K5/0205 ,  A61K47/6817 ,  A61K47/6851 ,  C07K7/02 ,  C07K16/32

摘要： and the use of such peptides in making immunoconjugates (i.e Antibody Drug Conjugates) Also described herein are immunoconjugates (i.e Antibody Drug Conjugates) comprising such novel cytotoxic peptide linked to an antigen binding moiety, such as an antibody; where such immunoconjugates are useful for treating cell proliferative disorders. The invention further provides pharmaceutical compositions comprising these immunoconjugates, compositions comprising the immunoconjugates with a therapeutic co-agent, and methods to use these immunoconjugates and compositions for treating cell proliferation disorders.

公开(公告)号：EP2470526B1

公开(公告)日：2014-05-28

申请号：EP10748211.9

申请日：2010-08-27

申请人： IRM LLC ,  Novartis AG

发明人： HUANG, Shenlin ,  JIN, Xianming ,  LIU, Zuosheng ,  POON, Daniel ,  TELLEW, John ,  WAN, Yongqin ,  WANG, Xing ,  XIE, Yongping

IPC分类号： C07D401/14 ,  C07D403/04 ,  A61K31/506 ,  A61P35/00

CPC分类号： C07D403/04 ,  A61K9/0053 ,  A61K31/4184 ,  A61K31/506 ,  A61K45/06 ,  C07D401/14 ,  C07D405/14 ,  A61K2300/00

摘要： The invention provides a novel class of compounds of formula 1, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.

公开(公告)号：EP1660458A1

公开(公告)日：2006-05-31

申请号：EP04764093.3

申请日：2004-08-13

申请人： Novartis AG ,  Novartis Pharma GmbH ,  IRM LLC

发明人： GARCIA-ECHEVERRIA, Carlos ,  KANAZAWA, Takanori ,  KAWAHARA, Eiji ,  MASUYA, Keiichi ,  MATSUURA, Naoko ,  MIYAKE, Takahiro ,  OHMORI, Osamu ,  UMEMURA, Ichiro ,  STEENSMA, Ruo ,  CHOPIUK, Greg ,  JIANG, Jiqing ,  WAN, Yongqin ,  DING, Qiang ,  ZHANG, Qiong ,  GRAY, Nathanael, Schiander ,  KARANEWSKY, Donald

IPC分类号： C07D239/48 ,  C07D405/12 ,  C07D403/12 ,  C07D401/12 ,  C07D401/14 ,  A61K31/506 ,  A61K35/00 ,  A61P37/00 ,  A61P29/00

CPC分类号： C07D239/48 ,  C04B35/632 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14

摘要： Novel pyrimidine derivatives of formula (I) Wherein R is selected from C16-10 aryl, C5-10heteroaryl, C3-12cycloalkyl and C3-10heterocycloalkyl; R0-R6 as described herein; and their use for the manufacture of a medicament for the treatment or prevention of a disease wich responds to inhibition of FAK and/or ALK and/or ZAP-70 and/or IGF-IR.

公开(公告)号：EP3082877B1

公开(公告)日：2019-08-28

申请号：EP14835606.6

申请日：2014-12-17

申请人： Novartis AG

发明人： GEIERSTANGER, Bernhard ,  GRUNEWALD, Jan ,  OU, Weijia ,  UNO, Tetsuo ,  WAN, Yongqin ,  WANG, Xing ,  JIN, Yunho

IPC分类号： A61K47/50 ,  C07K5/02

公开(公告)号：EP2470526A1

公开(公告)日：2012-07-04

申请号：EP10748211.9

申请日：2010-08-27

申请人： IRM LLC ,  Novartis AG

发明人： HUANG, Shenlin ,  JIN, Xianming ,  LIU, Zuosheng ,  POON, Daniel ,  TELLEW, John ,  WAN, Yongqin ,  WANG, Xing ,  XIE, Yongping

IPC分类号： C07D401/14 ,  C07D403/04 ,  A61K31/506 ,  A61P35/00

CPC分类号： C07D403/04 ,  A61K9/0053 ,  A61K31/4184 ,  A61K31/506 ,  A61K45/06 ,  C07D401/14 ,  C07D405/14 ,  A61K2300/00

摘要： The invention provides a novel class of compounds of formula 1, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.

摘要翻译： 本发明提供了一类新的式1化合物，包含这些化合物的药物组合物以及使用这些化合物治疗或预防与异常或失调的激酶活性有关的疾病或病症，特别是涉及异常活化B-Raf的疾病或病症的方法 。

公开(公告)号：EP1660458B1

公开(公告)日：2012-01-25

申请号：EP04764093.3

申请日：2004-08-13

申请人： Novartis AG ,  IRM LLC

发明人： GARCIA-ECHEVERRIA, Carlos ,  KANAZAWA, Takanori ,  KAWAHARA, Eiji ,  MASUYA, Keiichi ,  MATSUURA, Naoko ,  MIYAKE, Takahiro ,  OHMORI, Osamu ,  UMEMURA, Ichiro ,  STEENSMA, Ruo ,  CHOPIUK, Greg ,  JIANG, Jiqing ,  WAN, Yongqin ,  DING, Qiang ,  ZHANG, Qiong ,  GRAY, Nathanael, Schiander ,  KARANEWSKY, Donald

IPC分类号： C07D239/48 ,  C07D405/12 ,  C07D403/12 ,  C07D401/12 ,  C07D401/14 ,  A61K31/506 ,  A61K35/00 ,  A61P37/00 ,  A61P29/00

CPC分类号： C07D239/48 ,  C04B35/632 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14

摘要： Novel pyrimidine derivatives of formula (I) Wherein R is selected from C16-10 aryl, C5-10heteroaryl, C3-12cycloalkyl and C3-10heterocycloalkyl; R0-R6 as described herein; and their use for the manufacture of a medicament for the treatment or prevention of a disease wich responds to inhibition of FAK and/or ALK and/or ZAP-70 and/or IGF-IR.

公开(公告)号：EP3873938A1

公开(公告)日：2021-09-08

申请号：EP19813989.1

申请日：2019-10-30

申请人： Novartis AG ,  Chinook Therapeutics, Inc.

发明人： BARNETT, Lisa ,  BENDER, Steven ,  CHO, Charles, Y. ,  COX, Sarah ,  DEANE, Jonathan ,  GLASER, Scott, Martin ,  HAO, Xueshi ,  KASIBHATLA, Shailaja ,  OU, Weijia ,  UNO, Tetsuo ,  WAN, Yongqin ,  WEN, Ben ,  WU, Tom, Yao-Hsiang

IPC分类号： C07K16/28 ,  A61K31/52 ,  A61K47/68