公开(公告)号：EP1625158A2

公开(公告)日：2006-02-15

申请号：EP04731135.2

申请日：2004-05-05

申请人： NOVO NORDISK A/S

发明人： SENSFUSS, Ulrich ,  CONDE FRIEBOES, Kilian, Waldemar ,  CHRISTENSEN, Leif ,  PETTERSON, Ingrid, Vivika ,  HANSEN, Thomas, Kruse ,  ANKERSEN, Michael ,  MADSEN, Kjeld

IPC分类号： C07K14/68 ,  C07K7/06 ,  C07K7/04 ,  A61K38/08

CPC分类号： C07K7/02 ,  A61K38/00 ,  C07K7/56 ,  C07K14/68

摘要： Novel cyclic and linear peptides of the formula R1-x-x1-x2-x3-x4-x5-x6-x7-X8-X9-X10-X11-R2 are useful in the treatment of obesity are provided.

公开(公告)号：EP2076534A1

公开(公告)日：2009-07-08

申请号：EP07820878.2

申请日：2007-10-03

申请人： NOVO NORDISK A/S

发明人： NØRSKOV-LAURITSEN, Leif ,  CHRISTENSEN, Leif

IPC分类号： C07K14/575 ,  C12N15/12 ,  C07K16/26 ,  A61K38/22

CPC分类号： C07K14/57554

摘要： The present invention is concerned with peptides binding to the prolactin receptor, wherein said peptides have an improved binding via binding site 1 (BS1) to the prolactin receptor. In one embodiment, said improved binding is achieved by mutation of positions 61, 71 and 73.

公开(公告)号：EP2167116A2

公开(公告)日：2010-03-31

申请号：EP08717531.1

申请日：2008-03-07

申请人： Novo Nordisk A/S

发明人： BREINHOLT, Jens ,  BONDENSGAARD, Kent ,  CHRISTENSEN, Leif ,  NØRSKOV-LAURITZEN, Leif ,  LINGYUN, Wang ,  WEI, Gong ,  YUN, Liu ,  HU, Sean

IPC分类号： A61K38/22 ,  C07K14/575

CPC分类号： C07K14/57554 ,  A61K38/00

摘要： The invention relates to variants of prolactin, which variants have high affinity for the prolactin receptor.

公开(公告)号：EP2167059A2

公开(公告)日：2010-03-31

申请号：EP08802942.6

申请日：2008-07-03

申请人： Novo Nordisk A/S

发明人： BREINHOLT, Jens ,  NIELSEN, Per Franklin ,  CHRISTENSEN, Leif ,  NØRSKOV-LAURITSEN, Leif ,  SVENSSON, Anders

IPC分类号： A61K31/00 ,  C07K14/575

CPC分类号： C07K14/57554 ,  A61K38/00

摘要： The present invention relates to prolactin analogues, which analogues have increased resistance to deamidation.

摘要翻译： 本发明涉及催乳素类似物，其类似物对脱酰胺作用具有增强的抗性。

公开(公告)号：EP2086588A2

公开(公告)日：2009-08-12

申请号：EP07822420.1

申请日：2007-11-09

申请人： NOVO NORDISK A/S

发明人： PESCHKE, Bernd ,  CHRISTENSEN, Leif ,  PERSSON, Egon

IPC分类号： A61K47/48 ,  C07K14/575

CPC分类号： C07K14/57554 ,  A61K47/60

摘要： The invention is concerned with N-terminally pegylated polypeptides capable of binding to the prolactin receptor. Such polypeptides may for instance be N-terminally pegylated antagonists of the prolactin receptor, such as for instance prolactin variants.

公开(公告)号：EP1863841A1

公开(公告)日：2007-12-12

申请号：EP06725135.5

申请日：2006-03-17

申请人： Novo Nordisk A/S

发明人： PETTERSSON, Ingrid ,  CHRISTENSEN, Leif

IPC分类号： C07K14/68 ,  A61K38/34

CPC分类号： C07K14/5759 ,  A61K38/00 ,  A61K47/542 ,  A61K47/62

摘要： The present invention relates to novel peptide compounds which are effective in modulating one or more melanocortin receptor types, to the use of the compounds in therapy, to methods of treatment comprising administration of the compounds to patients in need thereof, and to the use of the compounds in the manufacture of medicaments. The compounds of the invention are of particular interest in relation to the treatment of obesity as well as a variety of diseases or conditions associated with obesity.

公开(公告)号：EP1809666A2

公开(公告)日：2007-07-25

申请号：EP05801398.8

申请日：2005-11-04

申请人： Novo Nordisk A/S

发明人： SENSFUSS, Ulrich ,  CHRISTENSEN, Leif ,  CONDE FRIEBOES, Kilian Waldemar ,  PETTERSSON, Ingrid

IPC分类号： C07K14/68

CPC分类号： C07K7/06 ,  A61K38/00 ,  C07K7/08

摘要： The present invention relates to novel peptide compounds which are effective in modulating one or more melanocortin receptor types, to the use of the compounds in therapy, to methods of treatment comprising administration of the compounds to patients in need thereof, and to the use of the compounds in the manufacture of medicaments. The compounds of the invention are of particular interest in relation to the treatment of obesity as well as a variety of diseases or conditions associated with obesity.

摘要翻译： 本发明涉及有效调节一种或多种黑皮质素受体类型的新型肽化合物，涉及该化合物在治疗中的用途，涉及包括将该化合物给予有需要的患者的治疗方法，以及涉及 化合物在药物制造中的应用。 本发明化合物在治疗肥胖以及与肥胖有关的各种疾病或病症方面特别有意义。

公开(公告)号：EP2094291A1

公开(公告)日：2009-09-02

申请号：EP07857950.5

申请日：2007-12-20

申请人： Novo Nordisk A/S

发明人： CHRISTENSEN, Leif ,  NØRSKOV-LAURITSEN, Leif ,  RISEGAARD, Lone ,  BILLESTRUP, Nils ,  TARABYKINA, Svetlana

IPC分类号： A61K38/22 ,  A61K47/22 ,  A61P35/00

CPC分类号： A61K38/2257 ,  A61K38/27 ,  A61K2300/00

摘要： The patent application relates to antagonistic dimers of prolactin molecules and their use in treating cancer.

摘要翻译： 该专利申请涉及催乳素分子的拮抗性二聚体及其在治疗癌症中的用途。

公开(公告)号：EP2057189A1

公开(公告)日：2009-05-13

申请号：EP07802841.2

申请日：2007-08-24

申请人： NOVO NORDISK A/S

发明人： LAU, Jesper ,  HANSEN, Thomas Kruse ,  CHRISTENSEN, Leif ,  MADSEN, Kjeld ,  SCHÄFFER, Lauge ,  SPETZLER, Jane

IPC分类号： C07K14/605 ,  A61K38/26 ,  A61P3/08 ,  A61P5/48

CPC分类号： C07K14/57563 ,  A61K38/00 ,  A61K38/26 ,  A61K47/48038 ,  A61K47/48046 ,  A61K47/48061 ,  A61K47/48215 ,  A61K47/542 ,  A61K47/543 ,  A61K47/545 ,  A61K47/60 ,  C07K14/605

摘要： This invention provides new therapeutic peptides, i.e. new protracted Exendin-4 compounds, pharmaceutical compositions and the use of such.

公开(公告)号：EP1907010A2

公开(公告)日：2008-04-09

申请号：EP06777657.5

申请日：2006-07-07

申请人： Novo Nordisk A/S

发明人： SENSFUSS, Ulrich ,  CHRISTENSEN, Leif ,  SPETZLER, Jane ,  FRIEBOES, Kilian Waldemar Conde ,  THØGERSEN, Henning

IPC分类号： A61K47/48 ,  C07K7/06 ,  C07K7/08

CPC分类号： C07K14/685 ,  A61K47/542 ,  A61K47/545

摘要： The present invention relates to novel peptide compounds which are effective in modulating one or more melanocortin receptor types, to the use of the compounds in therapy, to methods of treatment comprising administration of the compounds to patients in need thereof, and to the use of the compounds in the manufacture of medicaments. The compounds of the invention are of particular interest in relation to the treatment of obesity as well as a variety of diseases or conditions associated with obesity.