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    Quasirandom structure and function guided synthesis methods
    7.
    发明公开
    Quasirandom structure and function guided synthesis methods 审中-公开
    Durch Quasizufallsstrukturen und FunktionengeführteSynthesemethoden

    公开(公告)号：EP2175019A2

    公开(公告)日：2010-04-14

    申请号：EP09177376.2

    申请日：2003-12-19

    申请人： Nuevolution A/S

    发明人： Gouliaev, Alex, Haahr ,  Holtmann, Anette ,  Pedersen, Henrik ,  Franch, Thomas

    IPC分类号： C12N15/10 ,  C12P1/00 ,  C12Q1/68 ,  C07K1/04 ,  C07B61/00 ,  C40B20/04 ,  C40B40/06 ,  C40B30/04 ,  C40B50/08

    CPC分类号： C40B30/04 ,  C12N15/1068 ,  C40B20/04 ,  C40B40/06 ,  C40B50/04 ,  C40B50/08 ,  Y10T436/145555

    摘要： The present invention is directed to the synthesis of molecules guided by connector polynucleotides (CPNs) capable of hybridizing to complementory connector polynucleotides (CCPNs) harbouring at least one functional entity comprising at least one reactive group. At least one of said CCPNs hybridize to at least two CPNs. Each CPN will "call" for one or more CCPNs capable of hybridising to the CPN. Following the formation of a supramolecular hybridization complex comprising a plurality of CPNs and a plurality of CCPNs, the reaction of functional entity reactive groups result in the formation of a molecule comprising covalently linked functional entities. The formation of the molecule involves the transfer of functional entities from one or more "donor CCPNs" to at least one "acceptor CCPN" with which the transferred functional entities were not associated prior to the transfer.

    摘要翻译： 本发明涉及由能够与包含至少一个反应性基团的至少一个功能实体的互补连接子多核苷酸（CCPN）杂交的连接多核苷酸（CPN）引导的分子的合成。 至少一个所述CCPN与至少两个CPN杂交。 每个CPN将“呼叫”一个或多个能够与CPN杂交的CCPN。 在形成包含多个CPN和多个CCPN的超分子杂交复合物之后，功能性实体反应性基团的反应导致包含共价连接的功能性实体的分子的形成。 分子的形成涉及将功能性实体从一个或多个“供体CCPN”转移至至少一个转移的功能实体在转移之前不与其缔合的“受体CCPN”。