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1.发明公开COMPOSITIONS AND METHODS OF INHIBITING MASP-1 AND/OR MASP-2 AND/OR MASP-3 FOR THE TREATMENT OF VARIOUS DISEASES AND DISORDERS 审中-公开组合物和用于抑制方法MASP-1和/或MASP-2和/或MASP-3多种疾病和病症的治疗
公开(公告)号：EP2861246A4
公开(公告)日：2016-03-23
申请号：EP13807326
申请日：2013-06-18
申请人： OMEROS CORP , UNIV LEICESTER
CPC分类号： C07K16/40 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/18 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： In one aspect, the invention provides methods and compositions for inhibiting MASP-3-dependent complement activation in a subject suffering from or at risk for developing, a disease or disorder selected from the group consisting of paroxysmal nocturnal hemoglobinuria, age-related macular degeneration, arthritis, disseminated intravascular coagulation, thrombotic microangiopathy, asthma, dense deposit disease, pauci-immune necrotizing crescentic glomerulonephritis, traumatic brain injury, aspiration pneumonia, endophthalmitis, neuromyelitis optica and Behcet's disease by administering to the subject a composition comprising an amount of a MASP-3 inhibitory agent in an amount effective to inhibit MASP-3-dependent complement activation. In some embodiments, the subject is administered a MASP-2 inhibitory agent and a MASP-1 inhibitory agent, a MASP-2 inhibitory agent and a MASP-3 inhibitory agent administered, a MASP-3 inhibitory agent and a MASP-1 inhibitory agent, or a MASP-1 inhibitory agent, a MASP-2 inhibitory agent and a MASP-3 inhibitory agent.
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公开(公告)号：EP2427193A4
公开(公告)日：2013-04-03
申请号：EP10772372
申请日：2010-05-03
申请人： OMEROS CORP
发明人： BERGMANN JOHN E , CUTSHALL NEIL S , DEMOPULOS GREGORY A , FLORIO VINCENT A , GAITANARIS GEORGE , GRAY PATRICK , HOHMANN JOHN , ONRUST RENE , ZENG HONGKUI
IPC分类号： A61K31/50 , A61K31/137 , A61K31/195 , A61K31/38 , A61K31/415 , A61K31/425 , A61K31/433 , A61K31/519 , A61K31/527 , A61K45/06 , A61P25/14 , C07D471/04
CPC分类号： A61K31/551 , A61K31/00 , A61K31/085 , A61K31/122 , A61K31/137 , A61K31/192 , A61K31/195 , A61K31/198 , A61K31/381 , A61K31/4025 , A61K31/4162 , A61K31/425 , A61K31/433 , A61K31/4439 , A61K31/4985 , A61K31/505 , A61K31/506 , A61K31/519 , A61K31/527 , A61K31/542 , A61K45/06 , C07D471/04 , A61K2300/00
摘要： A method of treating a movement abnormality associated with the pathology of a neurological movement disorder, such as Parkinson's disease or Restless Leg(s) Syndrome by administering a therapeutically effective amount of a PDE7 inhibitory agent. An aspect of the invention provides for the administration of a PDE& inhibitory agent in conjunction with a dopamine agonist or precursor, such as levodopa. In another aspect of the invention, the PDE7 inhibitory agent may be selective for PDE7 relative to other molecular targets (i) known to be involved with the pathology of Parkinson's disease or (ii) at which other drug(s) that are therapeutically effective to treat Parkinson's disease act.
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3.发明公开THE USE OF PDE7 INHIBITORS FOR THE TREATMENT OF MOVEMENT DISORDERS 有权VERWENDUNG DES PDE7-HEMMERS ZUR BEHANDLUNG VONBEWEGUNGSSTÖRUNGEN
公开(公告)号：EP2139475A4
公开(公告)日：2012-03-07
申请号：EP08744515
申请日：2008-03-27
申请人： OMEROS CORP
发明人： BERGMANN JOHN E , CUTSHALL NEIL S , DEMOPULOS GREGORY A , FLORIO VINCENT A , GAITANARIS GEORGE , GRAY PATRICK , HOHMANN JOHN , ONRUST RENE , ZENG HONGKUI
IPC分类号： A61K31/435 , A61K31/195 , A61K31/433 , A61K31/519 , A61K31/527
CPC分类号： A61K31/195 , A61K31/433 , A61K31/519 , A61K31/527
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4.发明公开METHODS OF GENERATING BIOACTIVE PEPTIDE-BEARING ANTIBODIES AND COMPOSITIONS COMPRISING THE SAME 审中-公开用于生产生物活性肽佩带的抗体和组合物THEREFORE
公开(公告)号：EP2968546A4
公开(公告)日：2016-11-02
申请号：EP14764165
申请日：2014-03-14
申请人： OMEROS CORP
IPC分类号： A61K39/395 , C07K14/81 , C07K16/40
CPC分类号： C07K16/40 , A61K2039/505 , C07K14/811 , C07K16/00 , C07K2317/21 , C07K2317/23 , C07K2317/24 , C07K2317/52 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C07K2318/10 , C07K2319/00 , C07K2319/30
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