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    Cardiotonics
    4.
    发明公开
    Cardiotonics 失效
    Herzmittel。

    公开(公告)号：EP0355583A2

    公开(公告)日：1990-02-28

    申请号：EP89114712.6

    申请日：1989-08-09

    申请人： OTSUKA PHARMACEUTICAL CO., LTD.

    发明人： Fujioka, Takafumi ,  Teramoto, Shuji ,  Tominaga, Michiaki ,  Yabuuchi, Yoichi

    IPC分类号： A61K31/47 ,  C07D215/22 ,  C07D215/54 ,  C07D401/12 ,  C07D409/12

    CPC分类号： C07D215/227 ,  A61K31/47 ,  C07D215/54 ,  C07D401/12 ,  C07D409/12 ,  Y10S514/929

    摘要： Agent for prophylaxis and treatment of heart diseases using a carbostyril derivative of formula:
    wherein R 1 is H or CN, and R 2 and R 3 are each H, alkyl optionally substituted by OH, cycloalkyl, alkenyl, phenyl, phenylalkyl having optionally substituents of alkoxyalkoxy, halogen, alkoxy, N0 2 , alkyl, CN, alkylthio or alkylsulfinyl on phenyl ring and having optionally OH-substituent on alkyl moiety, phenylsulfonylalkyl having optionally alkoxy substituent on phenyl ring, phenylthioalkyl, phenylsulfinylalkyl having optionally substituents of halogen or alkoxy on phenyl ring, phenoxyalkyl having optionally substituents of halogen or alkoxy on phenyl ring, pyridylalkyl having optionally substituents of halogen or alkoxy on pyridine ring, thienylalkyl, benzoylalkyl, anilinothiocarbonyl, benzoyl, pyridyl, phenylalkenyl, or group of -A-NR 4 R 5 (R 4 and R 5 , are each alkyl or phenyl having optionally substituents of halogen or alkoxy on phenyl ring, and A is alkylene which may be interrupted with 0), and a salt thereof, and novel carbostyril derivatives, and pharmaceutical composition for prophylaxis and treatment of heart diseases containing said novel carbostyril derivative.

    摘要翻译： 使用下式的喹诺酮衍生物预防和治疗心脏病的药剂：其中R 1为H或CN，R 2和R 3各自为H，任选被OH取代的烷基，环烷基， 烯基，苯基，具有任选烷氧基烷氧基，卤素，烷氧基，NO 2，烷基，CN，烷硫基或烷基亚磺酰基在苯基环上并在烷基部分上具有任选OH-取代基的苯基烷基，在苯环上具有任选烷氧基取代基的苯基磺酰基烷基，苯硫基烷基， 任选取代基在苯环上具有卤素或烷氧基，在苯环上具有卤素或烷氧基的任意取代基的苯氧基烷基，吡啶环上任选取代基为卤素或烷氧基的吡啶基烷基，噻吩烷基，苯甲酰基烷基，苯硫基硫代羰基，苯甲酰基，吡啶基，苯基烯基或 - A-NR 4 R 5（R 4和R 5）各自是苯基上具有卤素或烷氧基的任意取代基的烷基或苯基，A是可以是 用O取代）及其盐，以及新的喹诺酮衍生物，以及用于预防和治疗含有所述新型喹诺酮衍生物的心脏病的药物组合物。