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公开(公告)号：EP3383298A1
公开(公告)日：2018-10-10
申请号：EP16813142.3
申请日：2016-12-01
发明人： PILPEL, Yair , DORON, Sivan , ZHERDEV, Yuri , LIOR, Erez , DEANGLIS, Ashley
摘要： The invention relates to syringes for storing and mixing components.
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2.发明公开
公开(公告)号：EP3086817A1
公开(公告)日：2016-11-02
申请号：EP14830890.1
申请日：2014-12-04
发明人： PILPEL, Yair , DEANGLIS, Ashley , ZHERDEV, Yuri , DORON, Sivan , GORMAN, Anne J. , NUR, Israel
CPC分类号： A61K38/4846 , A61K31/194 , A61K31/198 , A61K33/14 , A61K38/1767 , A61K38/36 , A61K38/363 , A61K38/4833 , A61L24/0015 , A61L24/106 , A61L2300/254 , A61L2300/418 , C12Y304/21005 , C12Y304/21006 , C12Y304/21021 , C12Y304/21022
摘要： Provided herein is a single component sealant formulation (e.g. in a liquid form), methods for its preparation, and use. The formulation includes fibrinogen; vitamin K-dependent clotting zymogens comprising at least Factor II (FII) and Factor X (FX).
摘要翻译： 本文提供了单组分密封剂制剂（例如液体形式），其制备方法和用途。 该制剂包括纤维蛋白原; 至少包含因子II（FII）和因子X（FX）的维生素K依赖性凝血酶原酶。
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公开(公告)号：EP3875123A1
公开(公告)日：2021-09-08
申请号：EP21169115.9
申请日：2014-12-04
发明人： PILPEL, Yair , DEANGLIS, Ashley , ZHERDEV, Yuri , DORON, Sivan , GORMAN, Anne J. , NUR, Israel
IPC分类号： A61L24/00 , A61P7/04 , A61P41/00 , A61L24/10 , A61K31/194 , A61K33/14 , A61K38/17 , A61K38/36 , A61K38/48 , A61K31/198
摘要： Provided herein is a single component sealant formulation (e.g. in a liquid form), methods for its preparation, and use. The formulation includes fibrinogen; vitamin K-dependent clotting zymogens comprising at least Factor II (FII) and Factor X (FX).
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4.发明公开DEVICE AND METHOD FOR PREPARING AND ADMINISTERING ONE-COMPONENT FIBRIN SEALANT 审中-公开VORRICHTUNG UND VERFAHREN ZUR HERSTELLUNG UND VERABREICHUNG EINES EINKOMPONENEN-FIBRINKLEBERS
公开(公告)号：EP3122260A1
公开(公告)日：2017-02-01
申请号：EP15721043.6
申请日：2015-03-25
发明人： PILPEL, Yair , DEANGLIS, Ashley , ZHERDEV, Yuri , DORON, Sivan , EREZ, Lior
CPC分类号： A61B17/00491 , A61K38/36 , A61K38/363 , A61K38/4833 , A61L24/106 , A61M3/005 , A61M2202/045 , C12Y304/21005
摘要： Provided herein are systems for preparing and delivering fibrin sealant to a surface and methods of use thereof. In one embodiment, the system comprises: a. a quantity of a liquid mixture disposed within a container (120), the mixture comprising: I. fibrin or II. fibrinogen and Factor II; and b. a resin bed (160) disposed within a vessel (158), the vessel (158) capable of being in fluid communication with the container (120), wherein when in fluid communication, passage of the mixture through the vessel (158) results in modification of the concentration of small molecules inhibitor(s) and/or inducer(s) within the mixture, favoring fibrin clot formation.
摘要翻译： 本文提供了用于制备和递送纤维蛋白密封剂到表面的系统及其使用方法。 在一个实施例中，系统包括：a。 一定量的液体混合物设置在容器内，该混合物包括：I.血纤蛋白或II。 纤维蛋白原和因子II; 和b。 设置在容器内的树脂床，容器能够与容器流体连通，其中当流体连通时，混合物通过容器导致改变小分子抑制剂和/或诱导剂的浓度 在混合物内，有利于纤维蛋白凝块的形成。
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公开(公告)号：EP3383298B1
公开(公告)日：2020-09-09
申请号：EP16813142.3
申请日：2016-12-01
发明人： PILPEL, Yair , DORON, Sivan , ZHERDEV, Yuri , LIOR, Erez , DEANGLIS, Ashley
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6.发明公开ONE COMPONENT FIBRIN GLUE COMPRISING A POLYMERIZATION INHIBITOR 审中-公开EINKOMPONENTEN-FIBRINKLEBER MIT EINEM POLYMERISATIONSINHIBITOR
公开(公告)号：EP3086818A1
公开(公告)日：2016-11-02
申请号：EP14831093.1
申请日：2014-12-04
发明人： PILPEL, Yair , DEANGLIS, Ashley , ZHERDEV, Yuri , DORON, Sivan , NUR, Israel
IPC分类号： A61L24/10
CPC分类号： A61L24/001 , A61L24/0015 , A61L24/106 , A61L24/108 , A61L2300/25 , A61L2300/434 , A61L2400/06
摘要： Provided herein are stable liquid sealant formulations comprising fibrin monomers and a reversible fibrin polymerization blocking agent, methods of preparing and using the formulations.
摘要翻译： 本文提供了包含纤维蛋白单体和可逆纤维蛋白聚合阻断剂的稳定的液体密封剂制剂，制备和使用制剂的方法。
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公开(公告)号：EP3086818B1
公开(公告)日：2018-10-31
申请号：EP14831093.1
申请日：2014-12-04
发明人： PILPEL, Yair , DEANGLIS, Ashley , ZHERDEV, Yuri , DORON, Sivan , NUR, Israel
IPC分类号： A61L24/10
CPC分类号： A61L24/001 , A61L24/0015 , A61L24/106 , A61L24/108 , A61L2300/25 , A61L2300/434 , A61L2400/06
摘要： Provided herein are stable liquid sealant formulations comprising fibrin monomers and a reversible fibrin polymerization blocking agent, methods of preparing and using the formulations.
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公开(公告)号：EP3808370A1
公开(公告)日：2021-04-21
申请号：EP20208584.1
申请日：2014-10-21
发明人： ORR, Nadav , PILPEL, Yair , DORON, Sivan
摘要： The present invention is directed to compounds useful in stabilizing thrombin activity, thrombin compositions comprising the compounds, methods of using the compounds and methods of identifying compounds capable of stabilizing thrombin activity. The compounds are preferably isolated peptides comprising or interacting with the gamma loop of thrombin.
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公开(公告)号：EP3194586A2
公开(公告)日：2017-07-26
申请号：EP15781152.2
申请日：2015-08-20
IPC分类号： C12N9/74 , C12N15/115 , A61K38/48
摘要： The present invention is directed to compounds, methods for stabilizing thrombin activity with a thrombin binding oligonucleotide and to stabilized thrombin. The thrombin binding oligonucleotide is capable of inhibiting thrombin activity whereby the inhibition can be reversed with an antisense oligonucleotide.
摘要翻译： 本发明涉及化合物，用凝血酶结合寡核苷酸稳定凝血酶活性和稳定凝血酶的方法。 凝血酶结合寡核苷酸能够抑制凝血酶活性，由此可以用反义寡核苷酸逆转抑制。
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公开(公告)号：EP3754017A3
公开(公告)日：2021-03-31
申请号：EP20176522.9
申请日：2015-08-20
IPC分类号： C12N9/74 , C12N15/115 , A61K38/48
摘要： The present invention is directed to compounds, methods for stabilizing thrombin activity with a thrombin binding oligonucleotide and to stabilized thrombin. The thrombin binding oligonucleotide is capable of inhibiting thrombin activity whereby the inhibition can be reversed with an antisense oligonucleotide.
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