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公开(公告)号：EP1546411A2
公开(公告)日：2005-06-29
申请号：EP03799119.7
申请日：2003-09-22
IPC分类号： C12Q1/68
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/136
摘要： Objective methods for detecting and diagnosing prostate cancer (PRC) or prostatic intraepithelial neoplasia (PIN) are described herein. In one embodiment, the diagnostic method involves the determining a expression level of PRC -associated gene that discriminate between PRC or PIN and nomal cell. The present invention further provides methods of screening for therapeutic agents useful in the treatment of either or both of PRC and PIN, methods of treating either or both of PRC and PIN and method of vaccinating a subject against either or both of PRC and PIN.
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公开(公告)号：EP1546197A2
公开(公告)日：2005-06-29
申请号：EP03799120.5
申请日：2003-09-22
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/136
摘要： The present application provides novel human gene MICAL2-PV whose expression is markedly elevated in prostate cancers. Furthermore, it provides polypeptides encoded by the gene as well as polypeptides encoded by PCOTH which expression was also discovered to be elevated in prostate cancers. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of prostate cancers, as target molecules for developing drugs against the disease, and for attenuating cell growth of prostate cancer.
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3.发明公开PKIB AND NAALADL2 FOR TARGET GENES OF PROSTATE CANCER THERAPY AND DIAGNOSIS 审中-公开PKIB和NAALADL2前列腺癌的诊断与治疗的靶基因
公开(公告)号：EP2195425A1
公开(公告)日：2010-06-16
申请号：EP08828317.1
申请日：2008-08-20
CPC分类号： A61K31/70 , A61K48/00 , C07K14/47 , C12N15/113 , C12N2310/111 , C12N2310/14
摘要： The invention features methods for detecting prostate cancer, especially hormone-refractory prostate cancer (HRPC) or castration-resistant prostate cancer (CRPC), by detecting over-expresion of PKIB or NAALADL2 compared the normal organs. Also disclosed are methods of identifying compounds for treating and preventing prostate cancer including HRPC, based on the over-expression of PKIB or NAALADL2 in the prostate cancer, the cell proliferation function of PKIB or NAALADL2, the intracellular localization of PKIB or NAALADL2 or the interaction between PKIB and PKA-C. Also, provided are a method for treating prostate cancer by administering a double-stranded molecule against the PKIB or NAALADL2 gene. The invention also provides products, including the double-stranded molecules and vectors encoding them, as well as compositions comprising the molecules or vectors, useful in the provided methods.
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公开(公告)号：EP1730279A2
公开(公告)日：2006-12-13
申请号：EP05710681.7
申请日：2005-02-18
CPC分类号： G01N33/5011 , A61K39/0011 , C12N15/1138 , C12N2310/14 , C12N2310/53 , C12Q1/6886 , C12Q1/6897 , C12Q2600/136 , C12Q2600/158 , G01N33/5023 , G01N33/57434 , Y10T436/143333
摘要： Objective methods for diagnosing a predisposition to developing prostate cancer (PRC) are described herein. In one embodiment, the diagnostic method involves the determining a expression level of EphA4. The present invention further provides methods of screening for therapeutic agents useful in the treatment of PRC, methods of treating PRC. The invention also features a method for inhibiting growth of a cancer cell by contacting the cell with a composition of a siRNA of EPHA4. Methods of treating cancer are also within the invention. The invention also features products, including nucleic acid sequences and vectors as well as to compositions comprising them, useful in the provided methods. The invention also provides a method for inhibiting of tumor cell, for example pancreatic cancer cell, particularly pancreatic ductal adenocarcinoma (PDACa).
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公开(公告)号：EP2064341A2
公开(公告)日：2009-06-03
申请号：EP07805927.6
申请日：2007-08-08
CPC分类号： C12Q1/6886 , A61K39/0011 , C12N9/1205 , C12N15/1137 , C12N2310/14 , C12N2310/53 , C12Q2600/136 , C12Y207/10002
摘要： The present invention provides methods for detecting and diagnosing cancer, which method involves the determination of the expression level of the STYK1 gene. The gene was discovered to discriminate cancer cells from normal cells. Furthermore, the present invention provides methods of screening for therapeutic agents useful in the treatment of cancer, methods for treating cancer, and methods for vaccinating a subject against cancer. Moreover, the present invention provides siRNAs targeting the STYK1 gene, which are suggested to be useful in the treatment of cancer.
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公开(公告)号：EP1991872A1
公开(公告)日：2008-11-19
申请号：EP07715266.8
申请日：2007-02-28
IPC分类号： G01N33/574 , C07K16/30
CPC分类号： C07K16/18 , C07K16/303 , G01N33/57438 , Y10T436/106664
摘要： REG4, a new member of REG family was identified as a biomarker of pancreatic adenocarcinoma. The present invention provides sandwich ELISA to detect serum REG4 in patients with resectable pancreatic cancers i.e. PDACs. The present invention also provides a method for diagnosing a pancreatic cancer using REG4 as a serological marker.
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公开(公告)号：EP1733047A2
公开(公告)日：2006-12-20
申请号：EP05710142.0
申请日：2005-02-04
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , A61K39/0011 , C12Q2600/136 , G01N33/57434 , G01N2500/10
摘要： Objective methods for diagnosing a predisposition to developing prostate cancer (PRC) are described herein. In one embodiment, the diagnostic method involves the determining a expression level of PRC -associated gene that discriminate between PRC and PIN. The present invention further provides methods of screening for therapeutic agents useful in the treatment of PRC, methods of treating PRC.
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公开(公告)号：EP2367939A1
公开(公告)日：2011-09-28
申请号：EP09827353.5
申请日：2009-11-18
IPC分类号： C12N15/09 , A61K31/713 , A61K48/00 , A61P35/00 , C12N15/113 , C12Q1/68 , G01N33/15
CPC分类号： C12Q1/6886 , C12N15/1136 , C12N2310/14 , C12N2310/531 , C12Q2600/112 , C12Q2600/136 , G01N33/57434 , G01N2500/04
摘要： The present invention provides methods for detecting and/or diagnosing cancer through the determination of the expression level of the STC2 gene. The gene was discovered to discriminate cancer cells from normal cells. Furthermore, the present invention provides methods of screening for therapeutic agents useful in the treatment of cancer, methods for treating cancer. Moreover, the present invention provides double-stranded molecules targeting the STC2 gene, which are suggested to be useful in the treatment of cancer. The compositions and methods of the present invention find particular applicability to prostate cancer, more specifically, castration-resistant prostate cancer and aggressive prostate cancer.
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公开(公告)号：EP1735442A2
公开(公告)日：2006-12-27
申请号：EP05721546.9
申请日：2005-03-18
IPC分类号： C12N15/11 , A61K31/7088
CPC分类号： C12N15/1138 , C12N2310/14 , C12N2310/53
摘要： The invention features a method for inhibiting growth of a cancer cell by contacting the cell with a composition of a siRNA that inhibits expression of PCDH1, CDH3 or GPR107. Methods of treating cancer are also within the invention. The invention also features products, including nucleic acid sequences and vectors as well as to compositions comprising them, useful in the provided methods. The invention also provides a method for inhibiting of tumor cell, for example pancreatic cancer cell, particularly pancreatic ductal adenocarcinoma (PDACa).
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公开(公告)号：EP1727831A1
公开(公告)日：2006-12-06
申请号：EP05721047.8
申请日：2005-03-11
IPC分类号： C07K14/47 , G01N33/574 , C12Q1/68 , C12N15/63 , C12N15/11 , C07K16/18 , A61K38/17 , C12N5/10
CPC分类号： C07K14/47 , A61K38/00 , G01N33/5011 , G01N33/57434
摘要： The present application provides novel human gene CCDC4 whose expression is markedly elevated in prostate cancers. The gene and polypeptide encoded by the gene can be used, for example, in the diagnosis of prostate cancers, as target molecules for developing drugs against the disease, and for attenuating cell growth of prostate cancer.
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