公开(公告)号：EP1546730A2

公开(公告)日：2005-06-29

申请号：EP03799081.9

申请日：2003-08-14

申请人： Oncotherapy Science, Inc. ,  The University of Tokyo

发明人： NAKAMURA, Yusuke ,  FURUKAWA, Yoichi

IPC分类号： G01N33/574 ,  C07K16/30 ,  C12Q1/68 ,  A61K39/00 ,  C07K14/47 ,  A61P35/04

CPC分类号： C07K14/4748 ,  A61K39/0011 ,  A61K2039/5154 ,  A61K2039/5158 ,  A61K2039/53 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/136 ,  G01N33/5023 ,  G01N33/57419 ,  G01N2500/04

摘要： Disclosed are methods of detecting metastasis of colorectal cancer using differentially expressed genes. Also disclosed are methods of identifying agents for treating colorectal cancer or preventing metastasis of colorectal cancer.

公开(公告)号：EP1532245A2

公开(公告)日：2005-05-25

申请号：EP03733286.3

申请日：2003-06-04

申请人： Oncotherapy Science, Inc. ,  The University of Tokyo

发明人： NAKAMURA, Yusuke ,  FURUKAWA, Yoichi

IPC分类号： C12N15/11 ,  C12N15/12 ,  C07K14/47 ,  C07K16/32 ,  A61K31/713 ,  A61K38/00 ,  A61K39/00 ,  C12Q1/68 ,  G01N33/68

CPC分类号： C07K16/303 ,  A61K38/00 ,  C07K14/4748 ,  C07K16/3046 ,  G01N33/57419 ,  G01N33/57438 ,  G01N33/6893 ,  G01N2500/00

摘要： The present application provides novel human genes WDRPUH and KRZFPUH, and PPIL1 whose expression is markedly elevated in a great majority of HCCs and colorectal cancers, respectively, compared to corresponding non-cancerous tissues, as well as novel human gene APCDD1 whose expression is elevated in primary colon cancers and down-regulated in response to the transduction of wild-type APC1 into colon-cancer cells. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of a cell proliferative disease, and as target molecules for developing drugs against the disease.

公开(公告)号：EP1668155A2

公开(公告)日：2006-06-14

申请号：EP04773341.5

申请日：2004-09-14

申请人： Oncotherapy Science, Inc. ,  The University of Tokyo

发明人： NAKAMURA, Yusuke ,  FURUKAWA, Yoichi

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  A61K39/0011 ,  A61K2039/57 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/111 ,  C12N2310/14 ,  C12Q2600/136 ,  G01N33/57438 ,  G01N2500/00

摘要： Objective methods for detecting, diagnosing, treating and preventing hepatocellular carcinoma (HCC) are described herein. In particular, the present invention relates to two genes up-regulated in HCC cells as compared to normal cells, referred to herein as MGC47816 and HES6. In one embodiment, the diagnostic method involves the determining the expression level of MGC47816 or HES6 that discriminate between hepatocellular carcinoma cellsand normal cells. The present invention further provides methods of screening for therapeutic agents useful in the treatment of HCC, methods of treating HCC, and methods for vaccinating a subject against HCC.

公开(公告)号：EP1554408A2

公开(公告)日：2005-07-20

申请号：EP03809437.1

申请日：2003-09-19

申请人： Oncotherapy Science, Inc. ,  The University of Tokyo

发明人： NAKAMURA, Yusuke ,  FURUKAWA, Yoichi

IPC分类号： C12Q1/68

CPC分类号： G01N33/57446 ,  A61K48/00 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N2500/00

摘要： Methods for detecting and diagnosing diffuse-type gastric cancer (DGC) are described herein. In one embodiment, the diagnostic method involves the determination of an expression level of DGC -associated gene that discriminate between DGC and normal cell. The present invention further provides methods of screening for therapeutic agents useful in the treatment of DGC, methods of treating DGC and method of vaccinating a subject against DGC.

公开(公告)号：EP1513934A2

公开(公告)日：2005-03-16

申请号：EP03730791.5

申请日：2003-06-03

申请人： Oncotherapy Science, Inc. ,  The University of Tokyo

发明人： NAKAMURA, Yusuke ,  FURUKAWA, Yoichi ,  TAHARA, Hideaki ,  TSUNODA, Takuya

IPC分类号： C12N15/11 ,  C12N15/12 ,  C07K14/47 ,  C07K16/32 ,  A61K31/713 ,  A61K38/00 ,  A61K39/00 ,  C12Q1/68 ,  G01N33/68

CPC分类号： C07K14/47 ,  C07K14/4748

摘要： The present application provides novel human genes RNF43 whose expression is markedly elevated in colorectal cancers, as well as CXADRL1 and GCUD1 whose expression is markedly elevated in gastric cancers compared to corresponding non-cancerous tissues. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of a cell proliferative disease, and as target molecules for developing drugs against the disease.

公开(公告)号：EP1492884A2

公开(公告)日：2005-01-05

申请号：EP03715738.5

申请日：2003-04-02

申请人： The University of Tokyo ,  Oncotherapy Science, Inc.

发明人： NAKAMURA, Yusuke ,  FURUKAWA, Yoichi

IPC分类号： C12Q1/68 ,  C07K14/47 ,  A61K39/00

CPC分类号： C12Q1/6809 ,  A61K39/00 ,  C07K14/47 ,  C12N9/90 ,  C12Q1/6886

摘要： The present application provides a human gene, HELAD1, whose expression is markedly elevated in a great majority of colorectal cancers as compared to corresponding non-cancerous tissues. Specifically, in investigating the mechanisms of colorectal carcinogenesis, genes regulated by adenomatous polyposis coli gene product (APC) were searched and the HELAD1 gene (helicase, APC down-regulated 1) was identified. A recombinant polypeptide representing the ATPases associated with cellular activities (AAA) domain of the HELAD1 product showed 3' to 5' helicase activity and exonuclease activity in vitro. HELAD1 was abundantly expressed in 16 of 20 colon cancers examined but hardly detectable in corresponding non-cancerous mucosae. Treatment of colon-cancer cells with antisense oligonucleotides suppressed its expression and induced apoptosis. This data demonstrates the importance of HELAD1 in colorectal carcinogenesis and its utility as a diagnostic marker of colorectal cancer. It further suggest that suppression of HELAD1 may be a promising therapeutic strategy in the treatment of colorectal cancer.

公开(公告)号：EP1434879A2

公开(公告)日：2004-07-07

申请号：EP02765616.4

申请日：2002-09-25

申请人： Japan as represented by The President of the University of Tokyo ,  Oncotherapy Science, Inc.

发明人： NAKAMURA, Yusuke ,  FURUKAWA, Yoichi

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6809 ,  C07K14/47 ,  C07K14/4748 ,  C12Q1/6886 ,  C12Q2600/158 ,  Y02P20/582

摘要： Genes up-regulated in hepatocellular carcinomas and polypeptides encoded by these genes are provided. Vectors, transformants and methods for producing the recombinant polypeptides are also provided. Probes and primers of these genes and antibodies against the polypeptides are also provided. The probes, primers and antibodies can be used as reagents for detecting hepatocellular carcinomas. Methods for detecting hepatocellular carcinomas using such detection reagents are further provided. Antisense nucleotide sequences of these genes are also provided and can be used to inhibit growth of hepatocellular carcinomas.

公开(公告)号：EP1789801A1

公开(公告)日：2007-05-30

申请号：EP05770406.6

申请日：2005-08-09

申请人： Oncotherapy Science, Inc. ,  The University of Tokyo

发明人： NAKAMURA, Yusuke ,  FURUKAWA, Yoichi ,  NAKATSURU, Shuichi

IPC分类号： G01N33/574

CPC分类号： G01N33/5011 ,  G01N33/5035 ,  G01N33/57419 ,  G01N2500/02

摘要： The present invention provides methods and kits for identifying inhibitors of the interaction between C20orf20 and p120 which find utility in the treatment and prevention of colon cancer. Also disclosed herein are compositions for treating or preventing colon cancer identified by the screening method of the present invention and methods of using same in the treatment and prevention of colon cancer.

公开(公告)号：EP1430152B1

公开(公告)日：2007-03-07

申请号：EP02765617.2

申请日：2002-09-25

申请人： Japan as represented by the president of the university of Tokyo ,  Oncotherapy Science, Inc.

发明人： NAKAMURA, Yusuke ,  FURUKAWA, Yoichi

IPC分类号： C12Q1/68

CPC分类号： C07K14/4748 ,  C12Q1/6809 ,  C12Q1/6886 ,  C12Q2600/158

摘要： The present application provides a novel human gene ZNFN3A1 whose expression is markedly elevated in a great majority of HCCs compared to corresponding non-cancerous liver tissues. The gene encodes a protein having a zinc finger domain as well as a SET domain and has been found to form a regulatory complex with RNA helicase and RNA polymerase.

公开(公告)号：EP1866436A1

公开(公告)日：2007-12-19

申请号：EP06713824.8

申请日：2006-02-09

申请人： Oncotherapy Science, Inc. ,  The University of Tokyo

发明人： NAKAMURA, Yusuke ,  FURUKAWA, Yoichi ,  NAKATSURU, Shuichi

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6897 ,  C07K14/4748 ,  C12N9/1007 ,  C12N15/1137 ,  C12N2310/14 ,  C12Q1/48 ,  C12Q1/6886 ,  C12Q2600/136 ,  G01N33/573 ,  G01N33/57415 ,  G01N2333/91011 ,  G01N2500/00

摘要： Objective methods for detecting and diagnosing breast cancer (BRC) are described herein. Also described are methods of treating and preventing breast cancer and breast cancer metastasis as well as methods of assessing the prognosis of a breast cancer subject and the efficacy of a breast cancer therapy. In one embodiment, the diagnostic method involves determining the expression level of ZNFN3A1, a gene whose expression is markedly elevated in breast cancers, that therefore can be used to discriminate between BRC cells and normal cells. The present invention further provides methods of screening for therapeutic agents useful in the treatment of BRC, methods of treating BRC and method for vaccinating a subject against BRC.