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公开(公告)号：EP3892627A1
公开(公告)日：2021-10-13
申请号：EP21163695.6
申请日：2018-05-03
发明人： JAYASINGHE, Lakmal Nishantha , WALLACE, Elizabeth Jayne , SINGH, Pratik Raj , HAMBLEY, Richard George , JORDAN, Michael , REMAUT, Han
IPC分类号： C07K14/245 , C12Q1/6869
摘要： Provided is a method of characterising a polynucleotide using a transmembrane pore, wherein the pore is a double pore comprising a first CsgG pore, or a homologue thereof, and a second CsgG pore, or a homologue thereof.
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公开(公告)号：EP3619224A1
公开(公告)日：2020-03-11
申请号：EP18727044.2
申请日：2018-05-03
发明人： JAYASINGHE, Lakmal Nishantha , WALLACE, Elizabeth Jayne , SINGH, Pratik Raj , HAMBLEY, Richard George , JORDAN, Michael , REMAUT, Han
IPC分类号： C07K14/245 , C12Q1/6869
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公开(公告)号：EP4273156A3
公开(公告)日：2024-01-17
申请号：EP23172407.1
申请日：2018-07-02
发明人： REMAUT, Han , VAN DER VERREN, Sander Egbert , VAN GERVEN, Nani , JAYASINGHE, Lakmal Nishantha , WALLACE, Elizabeth Jayne , SINGH, Pratik Raj , HAMBLEY, Richard George , JORDAN, Michael Robert , KILGOUR, John Joseph
IPC分类号： C07K14/245
摘要： The present invention relates to novel protein pores and their uses in analyte detection and characterisation. The invention particularly relates to an isolated pore complex formed by a CsgG-like pore and a modified CsgF peptide, or a homologue or mutant thereof, thereby incorporating an additional channel constriction or reader head in the nanopore. The invention further relates to a transmembrane pore complex and methods for production of the pore complex and for use in molecular sensing and nucleic acid sequencing applications.
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公开(公告)号：EP4273156A2
公开(公告)日：2023-11-08
申请号：EP23172407.1
申请日：2018-07-02
发明人： REMAUT, Han , VAN DER VERREN, Sander Egbert , VAN GERVEN, Nani , JAYASINGHE, Lakmal Nishantha , WALLACE, Elizabeth Jayne , SINGH, Pratik Raj , HAMBLEY, Richard George , JORDAN, Michael Robert , KILGOUR, John Joseph
IPC分类号： C07K14/245
摘要： The present invention relates to novel protein pores and their uses in analyte detection and characterisation. The invention particularly relates to an isolated pore complex formed by a CsgG-like pore and a modified CsgF peptide, or a homologue or mutant thereof, thereby incorporating an additional channel constriction or reader head in the nanopore. The invention further relates to a transmembrane pore complex and methods for production of the pore complex and for use in molecular sensing and nucleic acid sequencing applications.
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公开(公告)号：EP3440098A1
公开(公告)日：2019-02-13
申请号：EP17722128.0
申请日：2017-04-06
发明人： JAYASINGHE, Lakmal , BRUCE, Mark , MCNEILL, Luke , NATHANI, Ramiz Iqbal , SINGH, Pratik Raj , WOOD, Neil Roger , YOUNG, Stephen Robert
IPC分类号： C07K14/435 , C12Q1/68 , G01N27/447
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