公开(公告)号：EP1292298A4

公开(公告)日：2003-06-25

申请号：EP01926602

申请日：2001-04-03

申请人： PHOTOGEN INC

发明人： DEES H CRAIG ,  SCOTT TIMOTHY ,  WACHTER ERIC ,  FISHER WALTER ,  SMOLIK JOHN

IPC分类号： C07D311/82 ,  A61B17/00 ,  A61B17/22 ,  A61F7/00 ,  A61K9/00 ,  A61K9/02 ,  A61K9/06 ,  A61K9/08 ,  A61K9/10 ,  A61K9/12 ,  A61K9/20 ,  A61K9/48 ,  A61K31/352 ,  A61K41/00 ,  A61K47/10 ,  A61K47/12 ,  A61K47/20 ,  A61K47/48 ,  A61K49/00 ,  A61K49/04 ,  A61N5/06 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  A61P33/00 ,  A61P35/00 ,  A61P43/00 ,  A61K51/04

CPC分类号： A61K41/0038 ,  A61B2017/00057 ,  A61B2017/22062 ,  A61B2017/22087 ,  A61F7/00 ,  A61K9/0019 ,  A61K31/352 ,  A61K41/0057 ,  A61K41/008 ,  A61K47/10 ,  A61K47/12 ,  A61K47/20 ,  A61K47/6803 ,  A61K49/0041 ,  A61K49/0433 ,  A61N5/0601 ,  A61N5/062 ,  C07D311/82 ,  Y10S436/813 ,  Y10S436/819

摘要： New intracorporeal radiodense medicaments and certain medical uses and methods for use of such high energy phototherapeutic medicaments for treatment of human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative.

公开(公告)号：EP1210078A4

公开(公告)日：2004-06-09

申请号：EP00959216

申请日：2000-08-10

申请人： PHOTOGEN INC

发明人： DEES H CRAIG ,  SCOTT TIMOTHY ,  SMOLIK JOHN ,  WACHTER ERIC ,  FISHER WALTER

IPC分类号： A61B18/20 ,  A61K20060101 ,  A61K9/00 ,  A61K9/08 ,  A61K9/12 ,  A61K31/35 ,  A61K31/352 ,  A61K41/00 ,  A61K47/10 ,  A61K47/12 ,  A61K47/20 ,  A61K47/48 ,  A61N5/06 ,  A61P1/00 ,  A61P11/00 ,  A61P13/00 ,  A61P15/00 ,  A61P17/00 ,  A61P17/06 ,  A61P31/00 ,  A61P33/00 ,  A61P35/00 ,  A61P43/00 ,  C07D311/82 ,  C07D311/88

CPC分类号： A61K41/0057 ,  A61K9/0014 ,  A61K47/10 ,  A61K47/12 ,  A61K47/20 ,  C07D311/82

公开(公告)号：EP1284727A4

公开(公告)日：2004-06-02

申请号：EP01920579

申请日：2001-03-20

申请人： PHOTOGEN INC

发明人： DEES H CRAIG ,  SCOTT TIMOTHY ,  WACHTER ERIC ,  FISHER WALTER ,  SMOLIK JOHN

IPC分类号： A61K9/06 ,  A61B17/00 ,  A61B17/22 ,  A61F7/00 ,  A61K9/00 ,  A61K9/08 ,  A61K9/107 ,  A61K9/12 ,  A61K9/20 ,  A61K9/48 ,  A61K31/35 ,  A61K31/352 ,  A61K31/365 ,  A61K41/00 ,  A61K47/08 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/16 ,  A61K47/18 ,  A61K47/20 ,  A61K47/26 ,  A61K47/34 ,  A61K47/42 ,  A61K47/44 ,  A61K47/48 ,  A61K49/00 ,  A61K49/04 ,  A61N5/06 ,  A61P1/00 ,  A61P1/04 ,  A61P5/00 ,  A61P9/00 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P17/00 ,  A61P31/00 ,  A61P31/10 ,  A61P31/12 ,  A61P33/00 ,  A61P35/00 ,  A61P43/00 ,  C07D311/82 ,  A61P17/06

CPC分类号： A61K31/352 ,  A61B2017/00057 ,  A61B2017/22062 ,  A61B2017/22087 ,  A61F7/00 ,  A61K9/0019 ,  A61K41/0038 ,  A61K41/0057 ,  A61K41/0071 ,  A61K41/008 ,  A61K47/10 ,  A61K47/12 ,  A61K47/20 ,  A61K47/6803 ,  A61K49/0041 ,  A61K49/0433 ,  A61N5/0601 ,  A61N5/062 ,  C07D311/82 ,  Y10T436/153333 ,  Y10T436/19 ,  Y10T436/193333

摘要： New intracorporeal photodynamic medicaments and certain medical uses and methods for use of such photodynamic medicaments for treatment of disease in human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. In preferred embodiments, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs, the mouth and digestive tract and related organs, the urinary and reproductive tracts and related organs, the respiratory tract and related organs, the circulatory system and related organs, the head and neck, the endocrine and lymphoreticular systems and related organs, various other tissues, such as connective tissues and various tissue surfaces exposed during surgery, as well as various tissues exhibiting microbial or parasitic infection. In another preferred embodiment, such medicaments are produced in various formulations including liquid, semisolid, solid or aerosol delivery vehicles.

公开(公告)号：EP1187555A4

公开(公告)日：2004-12-01

申请号：EP00937691

申请日：2000-05-23

申请人： PHOTOGEN INC

发明人： FISHER WALTER ,  SMOLIK JOHN ,  DEES H CRAIG ,  WACHTER ERIC

IPC分类号： G01N21/64 ,  A61B5/00 ,  A61B5/103 ,  A61B10/00 ,  A61B6/00

CPC分类号： A61B5/444 ,  A61B5/0059 ,  A61B5/0091

摘要： A method and apparatus for diagnosis or imaging of a particular volume of material, including the steps of treating the particular volume of material with light sufficient to promote a multi-photon excitation of at least one photo-active agent contained on or within the particular volume of the material, wherein the at least one photo-active agent becomes active in the particular volume of the material, thereby resulting in the production of an optical signal, and wherein such optical signal is captured in electronic form for diagnosis or imaging of the particular volume of material.

公开(公告)号：EP1311261A4

公开(公告)日：2004-06-02

申请号：EP01954627

申请日：2001-07-10

申请人： PHOTOGEN INC

发明人： DEES H CRAIG ,  SCOTT TIMOTHY

IPC分类号： C07D311/82 ,  A61B17/22 ,  A61F7/00 ,  A61K9/00 ,  A61K9/06 ,  A61K9/08 ,  A61K9/12 ,  A61K31/352 ,  A61K41/00 ,  A61K47/10 ,  A61K47/12 ,  A61K47/20 ,  A61K47/48 ,  A61N5/06 ,  A61P31/00 ,  A61P35/00 ,  A61P43/00 ,  A61P17/06

CPC分类号： A61K41/0057 ,  A61B2017/22062 ,  A61B2017/22087 ,  A61F7/00 ,  A61K9/0014 ,  A61K9/0019 ,  A61K31/352 ,  A61K41/0071 ,  A61K47/10 ,  A61K47/12 ,  A61K47/20 ,  A61N5/0601 ,  A61N5/062 ,  C07D311/82 ,  Y10T436/193333

摘要： New chemotherapeutic medicaments and certain medical uses and methods for use of such chemotherapeutic medicaments for treatment of disease in human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. Preferably, the halogenated xanthene is Rose Bengal or a functional derivative of Rose Bengal. The halogenated xanthenes constitute a family of useful chemotherapeutic agents that afford selective, persistent accumulation in certain tissues. In preferred embodiments, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs, the mouth and digestive tract and related organs, the urinary and reproductive tracts and related organs, the respiratory tract and related organs, the circulatory system and related organs, the head and neck, the endocrine and lymphoreticular systems and related organs, various other tissues, such as connective tissues and various tissue surfaces exposed during surgery, as well as various tissues exhibiting microbial or parasitic infection. In another preferred embodiment, such medicaments are produced in various formulations useful for intracorporeal or topical administration, including in liquid, semisolid, solid or aerosol delivery vehicles.

公开(公告)号：EP1126782A4

公开(公告)日：2003-06-04

申请号：EP99971283

申请日：1999-10-26

申请人： PHOTOGEN INC

发明人： DEES H CRAIG ,  SCOTT TIMOTHY

IPC分类号： G01R33/28 ,  A61B5/055 ,  A61B6/00 ,  A61B6/03 ,  A61K31/352 ,  A61K41/00 ,  A61K49/00 ,  A61K49/04 ,  A61N5/06 ,  A61P35/00 ,  A61B5/00

CPC分类号： A61K49/0041 ,  A61K41/0057 ,  A61K41/008 ,  A61N5/0601 ,  A61N5/062

摘要： The present invention is directed to an apparatus and method of imaging and treatment using at least one photodynamic therapy ('PDT') agent. The method includes administering a photoactive agent to a patient (56), imaging the patient to locate the diseased tissue or tumors (54) in the patient using an imaging device (52) such as CAT scan or MRI, and treating the imaged diseased tissue with light (60) sufficient to photo-activate the agent in the tissue.

公开(公告)号：EP1146912A4

公开(公告)日：2003-05-21

申请号：EP00908366

申请日：2000-01-25

申请人： PHOTOGEN INC

发明人： WACHTER ERIC ,  SMOLIK JOHN ,  DEES H CRAIG

IPC分类号： A61K41/00 ,  A61K51/00 ,  A61P35/00

CPC分类号： A61K41/0038 ,  A61K51/00

摘要： A method is disclosed for treating a selected volume of tissue which method includes distributing a radiosensitizer and a plurality of ionizing radiation sources substantially within the volume of tissue to produce treatment zones that are generally uniformly distributed throughout the volume of tissue. An agent is also disclosed for treating such tissue, wherein the agent includes a radiosensitizer and an ionizing radiation source used in conjunction to define an injectable treatment agent.

公开(公告)号：EP0977592A4

公开(公告)日：2001-01-10

申请号：EP97946336

申请日：1997-10-28

申请人： PHOTOGEN INC

发明人： FISHER WALTER G ,  WACHTER ERIC A ,  DEES H CRAIG

IPC分类号： C07D487/22 ,  A61B17/00 ,  A61B19/00 ,  A61K41/00 ,  A61N5/06 ,  A61P35/00

CPC分类号： A61K41/0057 ,  A61B2017/00057 ,  A61K41/008 ,  A61N5/062 ,  B82Y15/00

摘要： A method for the treatment of a particular volume of plant or animal tissue comprising the steps of treating the plant or animal tissue with at least one photo-active molecular agent, wherein the particular volume of the plant or animal tissue retains at least a portion of the at least one photo-active molecular agent, and then treating the particular volume of the plant or animal tissue with light sufficient to promote a simultaneous two-photon excitation of at least one of the at least one photo-active molecular agent retained in the particular volume of the plant or animal tissue, wherein the at least one photo-active molecular agent becomes active in the particular volume of the plant or animal tissue. There is also disclosed a method for the treatment of cancer in plant or animal tissue and a method for producing at least one photo-activated molecular agent in a particular volume of a material.

公开(公告)号：EP1032321A4

公开(公告)日：2000-09-06

申请号：EP97948121

申请日：1997-10-27

申请人： PHOTOGEN INC

发明人： WACHTER ERIC A ,  FISHER WALTER G ,  DEES H CRAIG

IPC分类号： G01N21/64 ,  A61B17/00 ,  A61B19/00 ,  A61K41/00 ,  A61K49/00

CPC分类号： A61N5/062 ,  A61B2017/00057 ,  A61K41/008 ,  A61K49/0017 ,  A61K49/0039 ,  A61K49/0043 ,  B82Y15/00

摘要： A method for the imaging of a particular volume of plant or animal tissue, wherein the plant or animal tissue contains at least one photo-active molecular agent. The method comprises the steps of treating the particular volume of the plant or animal tissue with light sufficient to promote a simultaneous two-photon excitation of the photo-active molecular agent contained in the particular volume of the plant or animal tissue, photo-activating at least one of the photo-active molecular agents in the particular volume of the plant or animal tissue, thereby producing at least one photo-activated molecular agent, wherein the at least one photo-activated molecular agent emits energy, detecting the energy emitted by the at least one photo-activated molecular agent, and producing a detected energy signal which is characteristic of the particular volume of plant or animal tissue. The present invention also provides a method for the imaging of a particular volume of material, wherein the material contains at least one photo-active molecular agent.

公开(公告)号：EP1100394A4

公开(公告)日：2005-03-16

申请号：EP99940828

申请日：1999-07-29

申请人： PHOTOGEN INC

发明人： DEES H CRAIG ,  WACHTER ERIC A

IPC分类号： A61B18/20 ,  A61K41/00 ,  A61N5/06 ,  A61B19/00

CPC分类号： A61B18/203 ,  A61B2017/00769 ,  A61B2018/00452 ,  A61B2018/00458 ,  A61B2018/0047 ,  A61B2018/00476 ,  A61N5/062

摘要： This invention is a method, and apparatus for selectively photo-bleaching or killing pigmented tissues by photochemically converting pigments in the tissues using light (82), and specifically two photon excitation. Photo-toxic products thereby produced then kill pigmented cells. Hyperthermia or an exogenous agent can also be added to augment efficacy. The present invention is also directed to selective thermal destruction of pigmented tissues using related optical means.