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公开(公告)号：EP1899295A2
公开(公告)日：2008-03-19
申请号：EP06765590.2
申请日：2006-06-19
Applicant: Pfizer, Inc. , NICOX S.A.
Inventor： BENEDINI, Francesca , ONGINI, Ennio , NIESMAN, Michael Ross Agouron Pharmaceuticals Inc. , KRAUSS, Achim Agouron Pharmaceuticals Inc. , CHONG, Wesley K. M. Agouron Pharmaceuticals Inc. , CHIROLI, Valerio
IPC: C07C405/00 , C07D207/08 , C07D295/12 , A61K31/5575 , A61P27/06
CPC classification number: C07C405/00 , C07D207/08 , C07D295/12 , C07D295/13
Abstract: Nitroderivatives of prostaglandin amides having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.
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2.发明公开NITROOXY-COMPRISING DERIVATIVES OF APRACLONIDINE AND BRIMODNIDINE AS AL PHA2 -ADRENERGIC RECEPTOR AGONISTS 审中-公开亚硝酸根和亚胺酸的亚硝酸根衍生物作为AL PHA2 - 腺苷受体激动剂
公开(公告)号：EP1981852A1
公开(公告)日：2008-10-22
申请号：EP07726294.7
申请日：2007-02-02
Applicant: NicOx S.A. , Pfizer Inc.
Inventor： BENEDINI, Francesca , IMPAGNATIELLO, Francesco , BIONDI, Stefano , ONGINI, Ennio , CHONG, Wesley Kwan Mung
IPC: C07D233/50 , C07D239/76 , A61K31/41 , A61K31/495 , A61P9/00 , A61P29/00
CPC classification number: C07D233/50 , C07D239/76
Abstract: The present invention relates to alpha2-adrenergic receptor agonist nitrooxyderivatives of formula (I), wherein A is selected from (Ia) or (Ib) having improved pharmacological activity and enhanced tolerability. They can be employed for the treatment of ocular diseases, in particular high intraocular pressure and glaucoma. A-X1-Y-ONO2 (I)
Abstract translation: 本发明涉及式（I）的α2-肾上腺素能受体激动剂硝基氧基衍生物，其中A选自（Ia）或（Ib），其具有改善的药理学活性和增强的耐受性。 它们可以用于治疗眼部疾病，特别是高眼压和青光眼。 A-X1-Y-ONO2（I）
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公开(公告)号：EP1917239A1
公开(公告)日：2008-05-07
申请号：EP06765591.0
申请日：2006-06-19
Applicant: Pfizer, Inc. , NicOx S.A.
Inventor： BENEDINI, Francesca , CHIROLI, Valerio , CHONG, Wesley K.M. Agouron Pharm.Inc. A. Pfizer Co , KRAUSS, Achim Agouron Pharm. Inc. A Pfizer Co , NIESMAN, Michael R. Agouron Pharm.Inc. A Pfizer Co , ONGINI, Ennio
IPC: C07C405/00 , A61K31/5575 , A61P27/06
CPC classification number: A61K45/06 , A61K31/5575 , C07C405/00 , C07D211/22 , C07D295/088 , C07D295/13 , A61K2300/00
Abstract: Nitroderivatives of fluoroprostaglandins having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.
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4.发明授权GLUCOCORTICOIDS ATTACHED TO NITRATE ESTERS VIA AN AROMATIC LINKER IN POSITION 21 AND THEIR USE IN OPHTHALMOLOGY 有权上的芳香族连接位置21尼特拉·特斯特相关糖皮质激素和它们在眼
公开(公告)号：EP2318427B1
公开(公告)日：2013-10-23
申请号：EP09780232.6
申请日：2009-07-07
Applicant: Nicox S.A.
Inventor： BENEDINI, Francesca , BONFANTI, Annalisa , CHIROLI, Valerio , STEELE, Rebecca , ONGINI, Ennio , BIONDI, Stefano
IPC: C07J41/00 , C07J71/00 , A61K31/573 , A61P5/44 , A61P27/02
CPC classification number: C07J71/0031 , C07J41/005
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公开(公告)号：EP2109618A1
公开(公告)日：2009-10-21
申请号：EP08708271.5
申请日：2008-01-28
Applicant: Nicox S.A.
Inventor： BENEDINI, Francesca , BIONDI, Stefano , ONGINI, Ennio
IPC: C07J41/00 , A61K31/573 , A61P5/44
CPC classification number: C07J41/005
Abstract: The invention relates to nitrooxyderivative of corticosteroids of general formula (I) and pharmaceutically acceptable salts or stereoisomers thereof wherein R is the corticosteroid residue of formula (II): The compounds are useful in the treatment of respiratory diseases, inflammatory diseases, dermatological diseases and oculardiseases.
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Patent Agency Ranking6.发明授权NITROOXYDERIVATIVES OF CARVEDILOL AND OTHER BETA BLOCKERS AS ANTIHYPERTENSIVE DRUGS 有权NITROOXY-DERIVATE VON CARVEDILOL UND ANDEREN BETABLOCKERN ALS ANTIHYPERTENSIVA
公开(公告)号：EP1691804B1
公开(公告)日：2007-04-04
申请号：EP04803434.2
申请日：2004-12-01
Applicant: NicOx S.A.
Inventor： DEL SOLDATO, Piero , BENEDINI, Francesca , ONGINI, Ennio
IPC: A61K31/403 , C07D209/88 , C07C203/04 , A61P9/12
CPC classification number: C07C219/14 , C07C219/06 , C07C233/33 , C07C235/08 , C07C235/42 , C07C311/08 , C07C2601/08 , C07C2602/10 , C07D209/88
Abstract: The present invention relates to β-adrenergic blockers nitrooxyderivatives of general formula (I): A-(Y-ONO2)s, wherein s is an integer equal to 1 or 2; A is selected from the following β-adrenergic blockers residues of formula (II), wherein R1 is selected from the group consisting of: formula (IIa), formula (IIb), formula (IIc) or other residues defined in claim 1; R2 is selected from the group consisting of: -CH(CH3)2, -C(CH3)3 or formula (IIIa), formula (IIIb), Z is H or is a group capable of binding Y as defined in claim 1, Z1 is H or a -C(O)- capable of binding Y; the other substituents are defined in claim 1; and enantiomers and diastereoisomers and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing them and their use for the treatment of hypertension, cardiovascular diseases, glaucoma, migraine headache and vascular diseases.
Abstract translation: 本发明涉及通式（I）：A-（Y-ONO 2）s及其对映异构体和非对映异构体及其药学上可接受的盐，其含有它们的药物组合物及其用于治疗高血压，心血管的用途的β-肾上腺素能阻断剂 疾病，青光眼，偏头痛和血管疾病。
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7.发明授权NITROOXYDERIVATIVES OF FLUVASTATIN, PRAVASTATIN, CERIVASTATIN, ATORVASTATIN AND ROSUVASTATIN AS CHOLESTEROL-REDUCING AGENTS WITH IMPROVED ANTI-INFLAMMATORY, ANTITHROMBOTIC AND ANTIPLATELET ACTIVITY 有权氟伐他汀，普伐他汀，西伐他汀，阿托伐他汀的罗苏伐他汀的衍生物硝基氧基AS WITH IMPROVED抗炎，抗血栓形成和抗血小板锁定作用降胆固醇药
公开(公告)号：EP1626716B1
公开(公告)日：2007-02-07
申请号：EP04741636.7
申请日：2004-05-24
Applicant: NicOx S.A.
Inventor： BENEDINI, Francesca , ONGINI, Ennio , DEL SOLDATO, Piero
IPC: A61K31/405 , A61K31/40 , C07D209/26 , C07D207/34 , A61P3/06
CPC classification number: C07D207/34 , C07D209/24 , C07D213/55 , C07D239/42
Abstract: Nitrooxyderivatives of fluvastatin, cerivastatin, atorvastatin and rosuvastatin having improved pharmacological activity and enhanced tolerability are described. They can be employed for treating and/or preventing several diseases, in particular coronary syndromes, neurodegenerative disorders as well as for reducing cholesterol levels.
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公开(公告)号：EP1253924A1
公开(公告)日：2002-11-06
申请号：EP01909631.2
申请日：2001-01-16
Applicant: NICOX S.A.
Inventor： DEL SOLDATO, Piero , BENEDINI, Francesca , ANTOGNAZZA, Patrizia
CPC classification number: C07D215/56 , C07C237/26 , C07C2603/46 , C07D215/32 , C07D233/94 , C07D239/49 , C07D241/24 , C07D261/16 , C07D295/13 , C07D295/15 , C07D295/215 , C07D405/12 , C07D473/00 , C07D499/00 , C07D501/00 , C07H5/06 , C07H13/12 , C07H15/26 , C07H17/08
Abstract: Nitrate salts of antimicrobial agents for the preparation of antimicrobial medicaments, specifically antiviral, antifungal and antibacterial medicaments.
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公开(公告)号：EP1940863B1
公开(公告)日：2012-09-05
申请号：EP06776617.0
申请日：2006-08-04
Applicant: NICOX S.A. , FERRER INTERNACIONAL, S.A.
Inventor： BENEDINI, Francesca , ONGINI, Ennio , GUGLIETTA, Antonio , PALOP, Daniel , PRINCEP, Marta
CPC classification number: C07J43/003 , C07J41/005
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公开(公告)号：EP2321334A1
公开(公告)日：2011-05-18
申请号：EP09781020.4
申请日：2009-07-24
Applicant: Nicox S.A.
Inventor： BENEDINI, Francesca , CARZANIGA, Laura , ONGINI, Ennio , BIONDI, Stefano
CPC classification number: C07J41/005
Abstract: The invention relates to compounds of general formula (I) and pharmaceutically acceptable salts or stereoisomers thereof. The compounds are useful in the treatment of illnesses wherein the known steroid, parent or precursor steroid, is generally applied, with increased benefit in terms of pharmacological profile and fewer or milder side effects than those of the known steroids.
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