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14 条记录 (耗时 0.028 秒)

    INDOLE DERIVATIVES AS 5HT1-LIKE AGONISTS
    1.
    发明授权
    INDOLE DERIVATIVES AS 5HT1-LIKE AGONISTS 失效
    吲哚衍生物作为5-HT1样受体激动剂

    公开(公告)号：EP0785933B1

    公开(公告)日：1998-03-11

    申请号：EP95934124.9

    申请日：1995-09-29

    申请人： Pfizer Limited ,  Pfizer Research and Development Company, N.V./S.A.

    发明人： BROWN, Alan, Daniel

    IPC分类号： C07D403/14 ,  C07D405/14 ,  C07D401/14 ,  A61K31/40 ,  A61K31/445

    CPC分类号： C07D401/14 ,  C07D403/14 ,  C07D405/14

    摘要： Compounds of formula (I), pharmaceutically acceptable salts thereof, and pharmaceutically acceptable solvates (including hydrates) of either entity, wherein R1 is (a) R?2 is R3R4¿C(OH)A; V is C=O or CH¿2?; W is O or NR?5; R3 and R4¿ are each independently selected from H and C¿1?-C4 alkyl; or, together with the carbon atom to which they are attached, form a 4- or 5-membered carbocyclic ring; R?5¿ is H, benzyl, C¿1?-C5 alkanoyl or SO2(C1-C4)alkyl; A is C2-C3 alkylene; m is 0 or 1; and n is 0 or 1; with the provisos that when n is 1 and V is C=O then W is NH, and when n is 1 and V is CH2 then W is O; are selective 5-HT1-like agonists useful in the treatment of, inter alia, migraine, cluster headache, chronic paroxysmal hemicrania and headache associated with vascular disorders.

    PIPERIDINOYL-PYRROLIDINE AND PIPERIDINOYL-PIPERIDINE COMPOUNDS
    8.
    发明公开
    PIPERIDINOYL-PYRROLIDINE AND PIPERIDINOYL-PIPERIDINE COMPOUNDS 审中-公开
    哌啶甲酰基 - 吡咯烷和哌啶酰基 - 哌啶化合物

    公开(公告)号：EP1912968A1

    公开(公告)日：2008-04-23

    申请号：EP06779936.1

    申请日：2006-07-26

    申请人： Pfizer Limited

    发明人： ANDREWS, Mark David ,  BROWN, Alan, Daniel ,  FRADET, David Sebastien ,  LANSDELL, Mark Ian

    IPC分类号： C07D401/06 ,  C07D405/14 ,  A61K31/454 ,  A61K31/4545 ,  A61P3/04 ,  A61P15/00

    CPC分类号： C07D401/06 ,  C07D401/14 ,  C07D405/14

    摘要： The present invention relates to a class of compounds of general formula (I) and the salts, hydrates, solvates, polymorphs and prodrugs wherein n, R6, R7 and R10 are as defined herein and especially to MCR4 agonist compounds of formula (I), to their use in medicine, particularly in the treatment of sexual dysfunction and obesity, to intermediates useful in their synthesis and to compositions containing them.

    摘要翻译： 本发明涉及一类通式（I）的化合物及其盐，水合物，溶剂合物，多晶型物和前药，其中n，R 6，R 7和R 10如本文所定义，尤其涉及式（I）的MCR4激动剂化合物， 涉及它们在医学中的用途，特别是用于治疗性功能障碍和肥胖症，用于合成中的中间体和含有它们的组合物。