利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

7 条记录 (耗时 0.015 秒)

    METHODS FOR INHIBITING ANTIGEN SPECIFIC T CELL RESPONSES
    2.
    发明公开
    METHODS FOR INHIBITING ANTIGEN SPECIFIC T CELL RESPONSES 失效
    METHOD FOR THE抑制抗原特异性T细胞免疫应答的

    公开(公告)号：EP0784482A2

    公开(公告)日：1997-07-23

    申请号：EP95922279.0

    申请日：1995-06-07

    申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA

    发明人： BLAZAR, Bruce, R. ,  VALLERA, Daniel, A.

    IPC分类号： C12N15 ,  A61K39 ,  A61P37 ,  C07K14 ,  C07K16 ,  C07K19 ,  C12P21 ,  A61K38

    CPC分类号： C07K14/70521 ,  A61K38/00 ,  C07K16/247 ,  C07K16/2827 ,  C07K16/2845 ,  C07K16/2866 ,  C07K2319/00

    摘要： Methods for inhibiting antigen-specific T cell responses by use of an agent which inhibits a costimulatory signal in T cells are disclosed. Preferably, both a first agent which inhibits a costimulatory signal in the T cell (e.g., a CTLA4Ig fusion protein) and a second agent which inhibits another T cell function, such as adhesion of the T cell to a cell presenting antigen to the T cell, are used to inhibit antigen-specific T cell responses. For example, to inhibit adhesion of a T cell to a cell presenting antigen, an anti-LFA-1 antibody can be used in conjunction with a CTLA4Ig fusion protein. Alternatively, another agent which inhibits a costimulatory signal in T cells, such as an anti-B7-1 antibody or an anti-B7-2 antibody can be used with a second agent which inhibits a proliferative signal in the T cell e.g., an anti-IL-2 receptor antibody. The methods of the invention are particularly useful for inhibiting graft versus host disease and for inhibiting rejection of a transplanted tissue or organ.