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11 条记录 (耗时 0.013 秒)

    COMPLEXES D'INCLUSIONS COMPRENANT DU PIROXICAM, UNE CYCLODEXTRINE ET L'ARGININE
    1.
    发明授权
    COMPLEXES D'INCLUSIONS COMPRENANT DU PIROXICAM, UNE CYCLODEXTRINE ET L'ARGININE 有权
    EINSCHLUSSKOMPLEXE ENTHALTEND PIROXICAM，EIN CYKLODEXTRIN UND ARGININ

    公开(公告)号：EP1729813B1

    公开(公告)日：2011-04-06

    申请号：EP05744579.3

    申请日：2005-03-29

    申请人： PIERRE FABRE MEDICAMENT

    发明人： FREISS, Bernard ,  MARCIACQ, Florence ,  LOCHARD, Hubert

    IPC分类号： A61K47/48

    CPC分类号： C08B37/0015 ,  A61K31/5415 ,  A61K47/6951 ,  B82Y5/00

    摘要： The invention relates to a method for preparing a soluble inclusion complex comprising one or several active substances which are hardly soluble in an aqueous medium and are included in one or several host molecules, characterised in that it comprises the following successive stages: (a) one or several active substances are brought into contact with one or several host molecules; (b) initiation of a molecular diffusion stage by bringing a dense pressurized fluid into contact with the mixture obtained in stage (a) in a static mode in the presence of one or several diffusing agents; (c) recovery of the active substance- host molecule molecular complex thus formed; (d) initiation of a stage wherein an interaction agent is added to and mixed with the active substance host molecule molecular complex; (e) recovery of the soluble inclusion compound thus formed. The invention also relates to the soluble inclusion compound which can be obtained by said method, particularly a piroxicam-cyclodextrin-arginine compound.

    摘要翻译： 可溶性包合络合物包含难溶于包含一种或几种宿主分子的水性介质中的一种或几种活性物质，以及吡罗昔康 - 环糊精 - 精氨酸，其中在37℃下测定吡罗昔康在含有4g /升吡罗昔康的溶液中的溶解水平， 在5-120分钟的搅拌下高于90％，最特别高于99％。 包括以下的独立权利要求：（1）复合物的制备，涉及：与主体分子接触，引发分子扩散，形成的可溶性包合物的回收; （2）含有该复合物的药物组合物。

    PROCEDE DE PREPARATION DE COMPLEXES MOLECULAIRES
    6.
    发明授权
    PROCEDE DE PREPARATION DE COMPLEXES MOLECULAIRES 有权
    工艺生产分子络合物

    公开(公告)号：EP1638609B1

    公开(公告)日：2012-05-02

    申请号：EP04742568.1

    申请日：2004-04-23

    申请人： PIERRE FABRE MEDICAMENT

    发明人： LOCHARD, Hubert ,  SAUCEAU, Martial ,  FREISS, Bernard

    IPC分类号： A61K47/48 ,  A61K9/16 ,  A61K9/14

    CPC分类号： B82Y5/00 ,  A61K47/6951

    摘要： The invention relates to a method for the preparation of soluble molecular complexes, comprising one or more active substances which are poorly-soluble in an aqueous medium, included within one or more host molecules, characterised in comprising the following steps: (a) bringing one or more active substances into contact with one or more host molecules, (b) carrying out a molecular diffusion step by bringing a dense fluid into contact, under pressure, with the mixture obtained in (a), in static mode, in the presence of one or more diffusion agents and (c) recovery of the molecular complex thus formed.

    PROCEDE D'IMPREGNATION PAR CO2 SUPERCRITIQUE
    7.
    发明公开
    PROCEDE D'IMPREGNATION PAR CO2 SUPERCRITIQUE 有权
    超临界CO2浸渍工艺

    公开(公告)号：EP2429499A2

    公开(公告)日：2012-03-21

    申请号：EP10721462.9

    申请日：2010-05-12

    申请人： Pierre Fabre Medicament

    发明人： LOCHARD, Hubert ,  FREISS, Bernard

    IPC分类号： A61K9/18 ,  A61K31/165 ,  A61K31/192 ,  A61K31/216 ,  A61K31/475 ,  A61P25/18 ,  A61P13/10 ,  A61P21/04 ,  A61P29/00

    CPC分类号： A61K9/1694 ,  A61K9/1635 ,  A61K9/1652 ,  Y02A50/475

    摘要： The present invention relates to a batch method for impregnating a nonporous polymer pharmaceutical carrier with an active substance, characterised in that said method includes the following consecutive steps: a) mixing the active substance and the nonporous polymer pharmaceutical carrier, the pharmaceutical carrier being in a solid form and insoluble in supercritical CO
    2 and not being non-crosslinked polyvinylpyrrolidone; b) performing a step of molecular diffusion in the absence of water by contacting, in a static mode without agitation, the mixture obtained in step a) with supercritical CO
    2 at a pressure of 80 to 170 bars, at a temperature of 31 to 90°C for 1 to 6 hours; c) recovering the polymer pharmaceutical carrier impregnated with the active substance obtained in step b), the impregnated pharmaceutical carrier being nonporous and being in a solid form and the active substance being in an amorphous form, the method being implemented in the absence of an additional solvent. The invention further relates to a polymer pharmaceutical carrier in a nonporous solid form impregnated with an active substance characterised in that said carrier can be obtained by the method according to the present invention, in that the active substance is in an amorphous form and is water-soluble, and in that the polymer pharmaceutical carrier is not non-crosslinked polyvinylpyrrolidone and is insoluble in supercritical CO
    2 .

    PROCEDE D'ENRICHISSEMENT EN DHA
    8.
    发明公开
    PROCEDE D'ENRICHISSEMENT EN DHA 有权
    DHA富集过程

    公开(公告)号：EP1979450A1

    公开(公告)日：2008-10-15

    申请号：EP06830716.4

    申请日：2006-12-19

    申请人： PIERRE FABRE MEDICAMENT

    发明人： MARCIACQ, Florence ,  SOULAYRES, Mathieu ,  FREISS, Bernard

    IPC分类号： C11C1/08 ,  C11C1/00 ,  C11B7/00 ,  A23D9/007 ,  B01D11/04

    CPC分类号： C11B1/104 ,  A23D9/007 ,  C11B7/005 ,  C11C1/005 ,  C11C1/08 ,  C11C3/003 ,  Y02P20/544

    摘要： The present invention relates to a continuous process of DHA enrichment of a solution of fatty acids or derivatives thereof comprising less than 50% of DHA relative to the total fatty acids of the solution or to derivatives thereof, wherein the process comprises the steps of (a) simultaneous countercurrent injection, into a fractionation column, of the flow of the solution of fatty acids or of derivatives thereof and of a flow of supercritical CO2 at a temperature of less than or equal to 70°C and at a pressure of between 100×105 Pa and 160×105 Pa, wherein the level of supercritical CO2 is between 30 and 70, and (b) recovery of the residue comprising at least 50% of DHA relative to the total fatty acids of the residue or to derivatives thereof, wherein the DHA yield is greater than or equal to 60%.

    COMPLEXES D'INCLUSIONS COMPRENANT DU PIROXICAM, UNE CYCLODEXTRINE ET L'ARGININE OBTENUS PAR UN PROCEDE UTILISANT DU CO2 SUPERCRITIQUE ET UN AGENT POUR L'INTERACTION AVEC LE COMPLEXE
    10.
    发明公开
    COMPLEXES D'INCLUSIONS COMPRENANT DU PIROXICAM, UNE CYCLODEXTRINE ET L'ARGININE OBTENUS PAR UN PROCEDE UTILISANT DU CO2 SUPERCRITIQUE ET UN AGENT POUR L'INTERACTION AVEC LE COMPLEXE 有权
    包合物炎痛喜康，环糊精和精氨酸

    公开(公告)号：EP1729813A2

    公开(公告)日：2006-12-13

    申请号：EP05744579.3

    申请日：2005-03-29

    申请人： PIERRE FABRE MEDICAMENT

    发明人： FREISS, Bernard ,  MARCIACQ, Florence ,  LOCHARD, Hubert

    IPC分类号： A61K47/48

    CPC分类号： C08B37/0015 ,  A61K31/5415 ,  A61K47/6951 ,  B82Y5/00

    摘要： The invention relates to a method for preparing a soluble inclusion complex comprising one or several active substances which are hardly soluble in an aqueous medium and are included in one or several host molecules, characterised in that it comprises the following successive stages: (a) one or several active substances are brought into contact with one or several host molecules; (b) initiation of a molecular diffusion stage by bringing a dense pressurized fluid into contact with the mixture obtained in stage (a) in a static mode in the presence of one or several diffusing agents; (c) recovery of the active substance- host molecule molecular complex thus formed; (d) initiation of a stage wherein an interaction agent is added to and mixed with the active substance host molecule molecular complex; (e) recovery of the soluble inclusion compound thus formed. The invention also relates to the soluble inclusion compound which can be obtained by said method, particularly a piroxicam-cyclodextrin-arginine compound.