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19 条记录 (耗时 0.028 秒)

    COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
    1.
    发明公开
    COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR 审中-公开
    连接和方法激酶调节和其显示

    公开(公告)号：EP2516438A2

    公开(公告)日：2012-10-31

    申请号：EP10840075.5

    申请日：2010-12-21

    申请人： Plexxikon, Inc.

    发明人： IBRAHIM, Prabha N. ,  WU, Guoxian ,  LIN, Jack ,  SPEVAK, Wayne ,  CHO, Hanna ,  EWING, Todd ,  ZHANG, Chao

    IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P35/00

    CPC分类号： C07D471/04 ,  A61K31/437 ,  A61K31/497 ,  A61K31/498 ,  A61K31/506 ,  A61K31/519 ,  C07D519/00

    摘要： Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof are active on each of B-Raf, B-Raf V600E and c-Raf-1 protein kinase. In certain aspects and embodiments, the described compounds are active in inhibiting proliferation of a Ras mutant cell line. Also described are methods of use thereof to treat diseases and conditions, including melanoma, glioma, glioblastoma, pilocytic astrocytoma, liver cancer, biliary tract cancer, cholangiocarcinoma, colorectal cancer, lung cancer, bladder cancer, gallbladder cancer, breast cancer, pancreatic cancer, thyroid cancer, kidney cancer, ovarian cancer, adrenocortical cancer, prostate cancer, gastrointestinal stromal tumors, medullary thyroid cancer, tumor angiogenesis, acute myeloid leukemia, chronic myelomonocytic leukemia, childhood acute lymphoblastic leukemia, plasma cell leukemia, and multiple myeloma.

    COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
    3.
    发明公开
    COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR 有权
    连接和方法激酶调节和其显示

    公开(公告)号：EP2496086A1

    公开(公告)日：2012-09-12

    申请号：EP10829123.8

    申请日：2010-11-04

    申请人： Plexxikon, Inc.

    发明人： ZHANG, Jiazhong ,  IBRAHIM, Prabha, N. ,  BREMER, Ryan ,  SPEVAK, Wayne ,  CHO, Hanna

    IPC分类号： A01N43/90 ,  A61K31/519

    CPC分类号： C07D471/04 ,  A61K31/437 ,  A61K31/4427 ,  A61K31/506 ,  C07D401/04 ,  C07D401/14

    摘要： Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, or forms thereof are active on Fms protein kinase, or on Fms and Kit protein kinase, or on Fms and Flt-3 protein kinase. Also described are methods of use thereof to treat diseases and conditions, including diseases and conditions associated with activity of Fms protein kinase, Kit protein kinase, or Flt-3 protein kinase including rheumatoid arthiritis, osteoarthritis, multiple sclerosis, Alzheimer's disease, Parkinson's disease, glomerulonephritis, interstitial nephritis, Lupus nephritis, tubular necrosis, diabetic nephropathy, renal hypertrophy, acute myeloid leukemia, melanoma, multiple myeloma, metastatic breast cancer, prostate cancer, pancreatic cancer, neurofibromatosis, brain metastases, and gastrointestinal stromal tumors.