METHOD FOR CRYOGENICALLY COOLING FOOD PRODUCT

    公开(公告)号:EP3405045A1

    公开(公告)日:2018-11-28

    申请号:EP16714639.8

    申请日:2016-03-14

    IPC分类号: A23L3/375

    CPC分类号: A23L3/375

    摘要: Disclosed is a method for providing a desired amount of cooling to a quantity of food product in a vessel within a given period of time, comprising: (A) feeding cryogenic liquid which is not carbon dioxide out of a plurality of nozzle openings into a vessel directly into a formable mass of food product in the vessel at a flow rate effective to provide from each nozzle not greater than 1,900 BTUs of refrigeration to the formable mass of food product per minute from the cryogenic liquid delivered from each nozzle, while an impeller is moving the food product past the nozzle openings, wherein each nozzle opening is in direct contact with the food product and is at the interior surface of the vessel or is between the interior surface and the path of the impeller, (B) while maintaining the rate at which the formable mass of food product is moved past each nozzle opening to be sufficiently high so that the mass of food product remains formable as it is being cooled by contact with the cryogenic liquid, and (C) feeding said cryogenic liquid into said food product in accordance with steps (A) and (B) from a sufficient number of said nozzle openings to provide the desired amount of cooling to the quantity of food product within the given period of time. Also disclosed is an embodiment in which not greater than 30 pounds of cryogenic liquid per minute per nozzle is fed into the food product.

    SYSTEM AND METHOD FOR CONTROLLING A MAMMALIAN CELL CULTURE PROCESS
    8.
    发明公开
    SYSTEM AND METHOD FOR CONTROLLING A MAMMALIAN CELL CULTURE PROCESS 有权
    系统和方法控制与哺乳动物细胞培养过程的

    公开(公告)号:EP2313486A1

    公开(公告)日:2011-04-27

    申请号:EP09791206.7

    申请日:2009-08-06

    IPC分类号: C12M3/00 C12M1/06 C12N5/00

    CPC分类号: C12N1/38 C12M27/02 C12M29/22

    摘要: A system and method for controlling a mammalian cell culture process are provided. Such control of the cell culture process involves control of the level of dissolved carbon dioxide in the cell culture media and the resulting ability to prevent increases in the osmolality level is achieved by enhanced stripping of carbon dioxide with little or no damage to the mammalian cells. The disclosed methods and systems of dissolved carbon dioxide stripping include enhanced surface gas exchange mechanisms within the bioreactor vessel through the use of an upward flow impeller combined with vertical baffles to convert swirling motions of the liquid into a largely vertical flow;.