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19 条记录 (耗时 0.016 秒)

    DROPLET FORMATION USING FLUID BREAKUP
    1.
    发明公开
    DROPLET FORMATION USING FLUID BREAKUP 有权
    液滴形成按用途FLÜSSIGKEITSAUFBRECHUNG的

    公开(公告)号：EP2812103A1

    公开(公告)日：2014-12-17

    申请号：EP13707733.5

    申请日：2013-02-07

    申请人： President and Fellows of Harvard College

    发明人： ABATE, Adam, R. ,  WEITZ, David, A.

    IPC分类号： B01F3/08 ,  B01F5/04 ,  B01F13/00

    CPC分类号： B01F3/0803 ,  B01F3/0807 ,  B01F3/0865 ,  B01F5/0085 ,  B01F5/0471 ,  B01F13/0059 ,  B01L3/0241 ,  B01L3/50273 ,  B01L3/502776 ,  B01L3/502784 ,  B01L2200/0673 ,  Y10T137/0318 ,  Y10T137/87587

    摘要： The present invention generally relates to systems and methods for creating droplets. In one aspect, a plurality of droplets (27) is introduced into a continuous fluid stream (21) to cause the continuous fluid stream to form discrete droplets. In some cases, the droplets that are formed from the continuous fluid stream may be substantially monodisperse. The continuous fluid stream may, in some cases, be a jetting fluid stream flowing at a relatively high linear flow rate, and in certain embodiments, high rates of droplet formation from the jetting fluid may thereby be achieved. Additionally, certain aspects of the invention are generally directed to devices, such as microfluidic devices, able to form such droplets. For example, in one set of embodiments, a device may include a junction (14) where a plurality of droplets (27) can be introduced into a continuous fluid stream (21), and optionally, the device may include additional junctions (12) able to cause the formation of the plurality of droplets and/or the formation of the continuous fluid stream. Still other disclosed aspects are generally directed to methods of making such devices, methods of using such devices, kits involving such devices, and the like.

    DROPLET CREATION TECHNIQUES
    3.
    发明公开
    DROPLET CREATION TECHNIQUES 审中-公开
    VERFAHREN ZURTRÖPFCHENBILDUNG

    公开(公告)号：EP2493619A1

    公开(公告)日：2012-09-05

    申请号：EP10776469.8

    申请日：2010-10-26

    申请人： President and Fellows of Harvard College

    发明人： WEITZ, David, A. ,  ABATE, Adam, R.

    IPC分类号： B01L3/00 ,  B01F13/00

    CPC分类号： B01L3/502761 ,  B01F3/0807 ,  B01F13/0062 ,  B01F13/0071 ,  B01L3/502784 ,  B01L2200/0636 ,  B01L2200/0652 ,  B01L2300/0681 ,  Y10T137/0318 ,  Y10T137/8593

    摘要： The present invention is generally related to systems and methods for producing droplets. The droplets may contain varying species, e.g., for use as a library. In some cases, at least one droplet is used to create a plurality of droplets, using techniques such as flow-focusing techniques. In one set of embodiments, a plurality of droplets, containing varying species, can be divided to form a collection of droplets containing the various species therein. A collection of droplets, according to certain embodiments, may contain various subpopulations of droplets that all contain the same species therein. Such a collection of droplets may be used as a library in some cases, or may be used for other purposes.

    摘要翻译： 本发明通常涉及用于产生液滴的系统和方法。 液滴可以含有不同的物质，例如用作文库。 在一些情况下，使用诸如流动聚焦技术之类的技术，使用至少一个液滴来产生多个液滴。 在一组实施例中，包含不同种类的多个液滴可以被分开以形成其中包含各种物质的液滴的集合。 根据某些实施方案，液滴的集合可以包含在其中全部含有相同物质的各种液滴亚组。 这种液滴的集合在某些情况下可以用作文库，也可以用于其它目的。

    MULTIPLE EMULSIONS CREATED USING JETTING AND OTHER TECHNIQUES
    4.
    发明公开
    MULTIPLE EMULSIONS CREATED USING JETTING AND OTHER TECHNIQUES 审中-公开
    更多使用波束和其他技术生产的乳剂

    公开(公告)号：EP2473263A2

    公开(公告)日：2012-07-11

    申请号：EP10814401.5

    申请日：2010-09-01

    申请人： President and Fellows of Harvard College

    发明人： WEITZ, David, A. ,  THIELE, Julian, W.P. ,  ABATE, Adam, R.

    IPC分类号： B01F5/02 ,  B01F5/26 ,  B01F3/08 ,  B01F15/04

    CPC分类号： B01F3/0807 ,  B01F13/0062 ,  B01F13/0084 ,  B01F2003/0838 ,  B01F2215/045 ,  B01F2215/0459 ,  Y10T137/0318 ,  Y10T137/85938

    摘要： The present invention generally relates to emulsions, and more particularly, to multiple emulsions. In one aspect, multiple emulsions are formed by urging a fluid into a channel, e.g., by causing the fluid to enter the channel as a “jet.” Side channels can be used to encapsulate the fluid with a surrounding fluid. In some cases, multiple fluids may flow through a channel collinearly before multiple emulsion droplets are formed. The fluidic channels may also, in certain embodiments, include varying degrees of hydrophilicity or hydrophobicity. As examples, the fluidic channel may be relatively hydrophilic upstream of an intersection (or other region within the channel) and relatively hydrophobic downstream of the intersection, or vice versa. In some cases, the average cross-sectional dimension may change, e.g., at an intersection. For instance, the average cross-sectional dimension may increase at the intersection. Surprisingly, a relatively small increase in dimension, in combination with a change in hydrophilicity of the fluidic channel, may delay droplet formation of a stream of collinearly-flowing multiple fluids under certain flow conditions; accordingly, the point at which multiple emulsion droplets are formed can be readily controlled within the fluidic channel. In some cases, the multiple droplet may be formed from the collinear flow of fluids at (or near) a single location within the fluidic channel. In addition, unexpectedly, systems such as those described herein may be used to encapsulate fluids in single or multiple emulsions that are difficult or impossible to encapsulate using other techniques, such as fluids with low surface tension, viscous fluids, or viscoelastic fluids. Other aspects of the invention are generally directed to methods of making and using such systems, kits involving such systems, emulsions created using such systems, or the like.

    SPRAY DRYING TECHNIQUES
    5.
    发明公开
    SPRAY DRYING TECHNIQUES 审中-公开
    喷雾干燥工艺

    公开(公告)号：EP2654939A2

    公开(公告)日：2013-10-30

    申请号：EP11813839.5

    申请日：2011-12-20

    申请人： President and Fellows of Harvard College ,  BASF SE

    发明人： ABATE, Adam, R. ,  THIELE, Julian, W.P. ,  WEITZ, David, A. ,  WINDBERGS, Maike ,  HOLTZE, Christian

    IPC分类号： B01J2/04 ,  B05B7/04

    CPC分类号： B01D1/18 ,  A61K31/58 ,  F26B3/12

    摘要： The present invention generally relates to microfluidics, and to spray drying and other drying techniques. In some aspects, an article containing one or more channels or microfiuidic channels is used to mix one or more fluids prior to spray drying. The mixing may occur immediately before the fluids are expelled through a nozzle or other opening into a drying region of the spray dryer. In one set of embodiments, for example, a first fluid is exposed to a second fluid, then the fluids are exposed to air or other gases before being expelled through a nozzle. In certain instances, the first fluid may contain a dissolved species that may precipitate upon exposure to the second fluid; such precipitation may occur immediately before expulsion through a nozzle or other opening, thereby resulting in controlled precipitation as part of the spray drying process.

    ACOUSTIC WAVES IN MICROFLUIDICS
    9.
    发明公开
    ACOUSTIC WAVES IN MICROFLUIDICS 审中-公开
    SCHERWELLEN IN DER MIKROFLUIDIK

    公开(公告)号：EP2608878A2

    公开(公告)日：2013-07-03

    申请号：EP11820522.8

    申请日：2011-08-23

    申请人： President and Fellows of Harvard College ,  Universität Augsburg

    发明人： WEITZ, David, A. ,  FRANKE, Thomas ,  WIXFORTH, Achim ,  SCHMID, Lothar ,  AGRESTI, Jeremy ,  ABATE, Adam, R.

    IPC分类号： B01J19/10 ,  C12M1/42

    CPC分类号： C12M23/16 ,  B01L3/502761 ,  B01L3/502776 ,  B01L2200/0636 ,  B01L2200/0652 ,  B01L2300/0816 ,  B01L2400/0421 ,  B01L2400/0436 ,  B01L2400/0487 ,  B01L2400/0496 ,  C12M47/04 ,  F17D3/01 ,  G01N2015/1006 ,  G01N2015/1081 ,  Y10T137/0391

    摘要： Various aspects of the present invention relate to the control and manipulation of fluidic species, for example, in microfluidic systems. In one set of embodiments, droplets may be sorted using surface acoustic waves. The droplets may contain cells or other species. In some cases, the surface acoustic waves may be created using a surface acoustic wave generator such as an interdigitated transducer, and/or a material such as a piezoelectric substrate. The piezoelectric substrate may be isolated from the microfluidic substrate except at or proximate the location where the droplets are sorted, e.g., into first or second microfluidic channels. At such locations, the microfluidic substrate may be coupled to the piezoelectric substrate (or other material) by one or more coupling regions. In some cases, relatively high sorting rates may be achieved, e.g., at rates of at least about 1,000 Hz, at least about 10,000 Hz, or at least about 100,000 Hz, and in some embodiments, with high cell viability after sorting.

    摘要翻译： 本发明的各个方面涉及流体物质的控制和操作，例如在微流体系统中。 在一组实施例中，可以使用表面声波对液滴进行分类。 液滴可能含有细胞或其他物种。 在一些情况下，表面声波可以使用表面声波发生器（例如叉指传感器）和/或诸如压电基片的材料来产生。 压电衬底可以与微流体衬底隔离，除了在液滴被分类的位置处或附近，例如，进入第一或第二微流体通道。 在这样的位置处，微流体衬底可以通过一个或多个耦合区域耦合到压电衬底（或其它材料）。 在一些情况下，可以例如以至少约1000Hz，至少约10,000Hz或至少约100,000Hz的速率，并且在一些实施方案中，在分选后具有高的细胞活力来实现相对较高的分选率。

    SURFACES, INCLUDING MICROFLUIDIC CHANNELS, WITH CONTROLLED WETTING PROPERTIES
    10.
    发明公开
    SURFACES, INCLUDING MICROFLUIDIC CHANNELS, WITH CONTROLLED WETTING PROPERTIES 审中-公开
    微流体通道容纳区域具有受控的润湿性能

    公开(公告)号：EP2271581A1

    公开(公告)日：2011-01-12

    申请号：EP09724102.0

    申请日：2009-02-11

    申请人： President and Fellows of Harvard College

    发明人： ABATE, Adam, R. ,  KRUMMEL, Amber, T. ,  HOLTZE, Christian ,  WEITZ, David, A.

    IPC分类号： B81B1/00 ,  B01F13/00 ,  B01J19/00

    CPC分类号： F16L9/14 ,  B01F3/0807 ,  B01F13/0062 ,  B01J2219/00619 ,  B01J2219/00635 ,  B01J2219/00637 ,  B01L3/502707 ,  B81B2201/058 ,  B81B2203/0338 ,  B81C1/00206

    摘要： The present invention generally relates to coating materials, including photoactive coating materials. In some aspects of the invention, a sol-gel is provided that can be formed as a coating on a microfluidic channel. One or more portions of the sol-gel can be reacted to alter its hydrophobicity, in some cases. For instance, in one set of embodiments, a portion of the sol-gel may be exposed to light, such as ultraviolet light, which can be used to induce a chemical reaction in the sol-gel that alters its hydrophobicity. In one set of embodiments, the sol-gel can include a photoinitiator, that upon exposure to light, produces radicals. Optionally, the photoinitiator may be conjugated to a silane or other material within the sol-gel. The radicals so produced may be used to cause a polymerization reaction to occur on the surface of the sol-gel, thus altering the hydrophobicity of the surface. In some cases, various portions may be reacted or left unreacted, e.g., by controlling exposure to light (for instance, using a mask). Such treated surfaces within a microfluidic channel may be useful in a wide variety of applications, for instance, in the creation of emulsions such as multiple emulsions.