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公开(公告)号：EP4353324A3
公开(公告)日：2024-07-03
申请号：EP23214923.7
申请日：2015-01-12
IPC分类号： A61P37/02
CPC分类号： C07D498/04 , C07D519/00 , C07D513/04 , A61P1/02 , A61P1/04 , A61P1/16 , A61P1/18 , A61P11/00 , A61P11/02 , A61P11/04 , A61P11/06 , A61P13/10 , A61P13/12 , A61P15/00 , A61P15/14 , A61P17/00 , A61P17/04 , A61P17/06 , A61P17/14 , A61P19/00 , A61P19/02 , A61P21/00 , A61P21/04 , A61P25/00 , A61P25/04 , A61P25/06 , A61P27/02 , A61P27/06 , A61P27/12 , A61P27/14 , A61P27/16 , A61P29/00 , A61P3/00 , A61P3/04 , A61P31/00 , A61P35/00 , A61P35/02 , A61P3/06 , A61P37/02 , A61P37/08 , A61P5/00 , A61P7/00 , A61P7/02 , A61P7/06 , A61P9/00 , A61P9/10 , A61P9/12
摘要： The present invention provides bicyclic heterocyclyl kinase enzyme inhibitor compounds, and a pharmaceutically acceptable salt thereof, which are therapeutically useful as kinase inhibitors, particularly IRAK4 inhibitors that are useful in the treatment and prevention of diseases or disorder, in particular their use in diseases or disorder mediated by kinase enzyme, particularly IRAK4 enzyme.
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2.发明授权
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公开(公告)号：EP4190355B1
公开(公告)日：2024-09-25
申请号：EP22206709.2
申请日：2018-04-27
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： A61K39/39591 , C07K16/2875 , C07K2317/2120130101 , C07K2317/5220130101 , C07K2317/5520130101 , C07K2317/7620130101 , A61P11/00 , A61P13/08 , A61P13/12 , A61P15/14 , A61P19/08 , A61P19/10 , A61P3/14 , A61P35/00 , A61P35/04
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4.发明公开COMPOSITIONS AND METHODS USING IL-8 TO IMPROVE MILK PRODUCTION AND REPRODUCTIVE HEALTH IN MAMMALS 审中-公开用IL-8改善哺乳动物奶生产和生殖健康的组合物和方法
公开(公告)号：EP3242675A1
公开(公告)日：2017-11-15
申请号：EP16735288.9
申请日：2016-01-05
申请人： Cornell University
IPC分类号： A61K38/00
CPC分类号： A61K38/2053 , A23C9/20 , A23C2230/10 , A23K20/147 , A23K50/10 , A23V2002/00 , A61K9/0034 , A61P3/00 , A61P15/14 , A23V2250/542
摘要： The present disclosure provides compositions and methods for improving reproductive health of mammals and increasing milk production from female mammals. The methods involve administering an effective amount of IL-8 to a female mammal such that the reproductive health of the mammal is improved, or milk production from the mammal is increased, or the fat content of the milk is increased. In another aspect the disclosure includes prophylaxis and/or therapy of uterine conditions by administering IL-8 to a female mammal.
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5.发明公开
公开(公告)号：EP4378536A2
公开(公告)日：2024-06-05
申请号：EP24156804.7
申请日：2015-07-15
发明人： BOURNE, Gregory , BHANDARI, Ashok , CHENG, XiaoLi , FREDERICK, Brian Troy , ZHANG, Jie , PATEL, Dinesh V. , LIU, David
IPC分类号： A61P43/00
CPC分类号： G01N2800/06520130101 , C07K14/54 , A61K38/00 , A61P1/00 , A61P1/04 , A61P1/16 , A61P1/18 , A61P11/00 , A61P11/02 , A61P11/06 , A61P15/14 , A61P17/06 , A61P19/02 , A61P35/00 , A61P37/06 , A61P43/00 , A61P5/48 , A61P3/10
摘要： The present invention provides novel peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of diseases and disorders, including inflammatory bowel disease.
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公开(公告)号：EP4374878A2
公开(公告)日：2024-05-29
申请号：EP24166417.6
申请日：2011-09-29
申请人： Ferring B.V.
IPC分类号： A61K47/20
CPC分类号： A61K9/0019 , A61K9/0043 , A61K47/12 , A61K47/183 , A61K38/095 , A61K38/12 , A61K47/20 , A61P1/00 , A61P1/04 , A61P1/10 , A61P1/14 , A61P15/00 , A61P15/04 , A61P15/08 , A61P15/10 , A61P15/14 , A61P17/02 , A61P19/10 , A61P25/00 , A61P25/04 , A61P25/18 , A61P25/22 , A61P25/24 , A61P29/00 , A61P31/04 , A61P35/00 , A61P43/00 , A61P5/10 , A61P7/04 , A61P7/06 , A61K9/08
摘要： The present invention relates to pharmaceutical compositions having improved stability.
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公开(公告)号：EP4324527A3
公开(公告)日：2024-04-24
申请号：EP23205739.8
申请日：2013-09-11
发明人： LORENZ, Douglas Alan , KONAGURTHU, Sanjay , WALD, Randy J. , EVERETT, Jason A. , MATZ, Sheila , TAKAISHI, Yuuki , SAKAI, Toshiro , IRIE, Ryousuke , OBA, Shinsuke , TOYOTA, Hiroyasu , NISHIMURA, Koji , KANBAYASHI, Atsushi
IPC分类号： C07D233/86 , A61K31/4166 , A61P35/00 , A61K9/14 , A61K9/20 , A61K9/16 , A61P13/08 , A61P15/00 , A61P15/08 , A61P15/14 , A61P43/00
CPC分类号： A61K31/4166 , A61P13/08 , A61P15/00 , A61P15/08 , A61P15/14 , A61K9/1652 , A61K9/1635 , A61P35/00 , A61P43/00 , C07D233/86 , A61K9/146 , A61K9/2054 , A61K9/2027 , A61K9/2095
摘要： This disclosure provides formulations of enzalutamide and their use for treating hyperproliferative disorders.
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8.发明公开
公开(公告)号：EP4378536A3
公开(公告)日：2024-10-09
申请号：EP24156804.7
申请日：2015-07-15
发明人： BOURNE, Gregory , BHANDARI, Ashok , CHENG, XiaoLi , FREDERICK, Brian Troy , ZHANG, Jie , PATEL, Dinesh V. , LIU, David
CPC分类号： G01N2800/06520130101 , C07K14/54 , A61K38/00 , A61P1/00 , A61P1/04 , A61P1/16 , A61P1/18 , A61P11/00 , A61P11/02 , A61P11/06 , A61P15/14 , A61P17/06 , A61P19/02 , A61P35/00 , A61P37/06 , A61P43/00 , A61P5/48 , A61P3/10
摘要： The present invention provides novel peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of diseases and disorders, including inflammatory bowel disease.
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公开(公告)号：EP4380915A1
公开(公告)日：2024-06-12
申请号：EP22854112.4
申请日：2022-08-05
申请人： Zoetis Services LLC
发明人： PHELPS, Hilary , BEAM, Brianna Joy Pomeroy , EWIN, Richard Andrew , ZOOK, Christopher A. , KUHN, Michael , ZENG, Xi
IPC分类号： C07C43/23 , A61K31/085
CPC分类号： Y02A50/30 , A61P31/00 , A61K38/1729 , A61P15/14 , C07K14/4723 , A61P31/04 , A61K9/0041 , A61K9/0019
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公开(公告)号：EP4353324A2
公开(公告)日：2024-04-17
申请号：EP23214923.7
申请日：2015-01-12
IPC分类号： A61P37/02
CPC分类号： C07D498/04 , C07D519/00 , C07D513/04 , A61P1/02 , A61P1/04 , A61P1/16 , A61P1/18 , A61P11/00 , A61P11/02 , A61P11/04 , A61P11/06 , A61P13/10 , A61P13/12 , A61P15/00 , A61P15/14 , A61P17/00 , A61P17/04 , A61P17/06 , A61P17/14 , A61P19/00 , A61P19/02 , A61P21/00 , A61P21/04 , A61P25/00 , A61P25/04 , A61P25/06 , A61P27/02 , A61P27/06 , A61P27/12 , A61P27/14 , A61P27/16 , A61P29/00 , A61P3/00 , A61P3/04 , A61P31/00 , A61P35/00 , A61P35/02 , A61P3/06 , A61P37/02 , A61P37/08 , A61P5/00 , A61P7/00 , A61P7/02 , A61P7/06 , A61P9/00 , A61P9/10 , A61P9/12
摘要： The present invention provides bicyclic heterocyclyl kinase enzyme inhibitor compounds, and a pharmaceutically acceptable salt thereof, which are therapeutically useful as kinase inhibitors, particularly IRAK4 inhibitors that are useful in the treatment and prevention of diseases or disorder, in particular their use in diseases or disorder mediated by kinase enzyme, particularly IRAK4 enzyme.
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