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    PROCESS FOR PREPARING A (METH)ACRYLATE COPOLYMER CONTAINING QUATERNARY AMMONIUM GROUPS BY FREE-RADICAL POLYMERIZATION IN SOLUTION
    2.
    发明公开
    PROCESS FOR PREPARING A (METH)ACRYLATE COPOLYMER CONTAINING QUATERNARY AMMONIUM GROUPS BY FREE-RADICAL POLYMERIZATION IN SOLUTION 有权
    用于生产（甲基）季氨基丙烯酸酯共聚物，具有自由基聚合在溶液中

    公开(公告)号：EP2627684A1

    公开(公告)日：2013-08-21

    申请号：EP10771068.3

    申请日：2010-10-13

    申请人： Evonik Röhm GmbH

    发明人： MEIER, Christian ,  WEBER, Andreas ,  VORHOLZ, Johannes ,  KÜKSAL, Alpertunga ,  KLOSENDORF, Andreas ,  BÖHMANN, Pamela ,  DENGER, Marcus ,  HOFFMANN, Norbert ,  PAPADOPOULOS, Nikolaos

    IPC分类号： C08F220/34 ,  C08F220/12

    CPC分类号： C08F2/06 ,  C08F220/12 ,  C08F220/34

    摘要： The invention relates to a process for preparing a (meth)acrylate copolymer containing quaternary ammonium groups from a monomer mixture selected from: (a) 80 to 99 % by weight of a C1-C4-alkyl ester of acrylic acid or methacrylic acid; and (b) 20 to 1 % by weight of an alkyl ester of acrylic acid or methacrylic acid with a quaternary ammonium group in the alkyl radical; and (c) 0 to 10 % of further copolymerizable vinyl monomers whereby one or more polymerization initiators, optionally one or more molecular weight regulators and one or more solvents or of a solvent mixture are added to the monomer mixture to give a polymerization mixture, which is polymerized at temperatures from 30 to 120 C over a period of 2 to 24 hours, where the polymerization mixture is polymerized to a polymerization syrup with a conversion of the monomers to the copolymer of at least 99 % by weight, where the polymerization syrup is subsequently degassed by distillation or by extrusion and the degassed polymerization syrup is further comminuted to a copolymer preparation in the form of a granulate or powder and where the copolymer preparation is characterized by a molecular weight (Mw) of 25.000 to 50.000, a polydispersity index of 2.0 to 3.0 and a residual solvent concentration of less than 10.000 ppm by weight.

    A PROCESS FOR CONVERTING A SOLID (METH)ACRYLATE COPOLYMER INTO A DISPERSED FORM BY MEANS OF A DISPERSING AGENT
    3.
    发明公开
    A PROCESS FOR CONVERTING A SOLID (METH)ACRYLATE COPOLYMER INTO A DISPERSED FORM BY MEANS OF A DISPERSING AGENT 有权
    PROCESS FOR A固体（甲基）丙烯酸酯共聚物为分散形式的转换装置的分散剂

    公开(公告)号：EP2501368A1

    公开(公告)日：2012-09-26

    申请号：EP09756717.6

    申请日：2009-11-16

    申请人： Evonik Röhm GmbH

    发明人： ROTH, Erna ,  ALEXOWSKY, Rüdiger ,  PETEREIT, Hans-Ulrich ,  NOLLENBERGER, Kathrin ,  MEIER, Christian

    IPC分类号： A61K9/28 ,  A61K9/50 ,  A61K9/70 ,  C08J3/03 ,  C08J3/05

    CPC分类号： C08J3/03 ,  A61K9/284 ,  A61K9/5026 ,  A61K9/5089 ,  C08J3/05 ,  C08J2333/14

    摘要： The present invention provides a process for converting a solid (meth)acrylate copolymer into a dispersed form by preparing an aqueous dispersion comprising the components (a) a (meth)acrylate copolymer which is composed of free-radical polymerized methyl methacrylate, ethylacrylate and a salt of 2-trimethylammoniumethyl methacrylate, present in solid form as a powder or as a granulate, (b) up to 50% by weight calculated on the (meth)acrylate copolymer (a) of a dispersing agent selected from the groups of (b) i) plasticizers in combination with emulsifiers and/or (b) ii) pharmaceutically acceptable carbohydrates having 6 to 18 carbon atoms with a functional group and (c) water by mixing the components (a), (b) and (c) to give a suspension which becomes an aqueous dispersion during the conversion of the solid (meth)acrylate copolymer into the dispersed form, characterized in that, the (meth)acrylate copolymer is converted into the dispersed form by means of the presence of the dispersing agent at a temperature of less than 50° C.

    摘要翻译： 本发明提供了一种通过制备的水性分散体，包括其由自由基聚合甲基丙烯酸甲酯，丙烯酸乙酯和一的组分（a）的（甲基）丙烯酸酯共聚物的全部转换为固体（甲基）丙烯酸酯共聚物为分散形式 2-三甲基铵乙基甲基丙烯酸酯的盐，以固体形式存在作为粉末或作为颗粒，（b）至多50％（重量）计算的（甲基）丙烯酸酯共聚物（a）从各组中选择的分散剂的（b ）ⅰ）增塑剂结合乳化剂和/或（b）ii）以组分（a），（b）和（c）将具有带官能团和（c）水6-18个碳原子的药学上可接受的碳水化合物 得到悬浮液在成为固体（甲基）的转化丙烯酸酯共聚物为分散形式，在该特征的期间wässrige分散体中，（甲基）丙烯酸酯共聚物是由dispersin的存在的手段转化为分散形式 克剂在低于50℃的温度

    MEHRSCHICHTIGE ARZNEIFORM
    4.
    发明授权
    MEHRSCHICHTIGE ARZNEIFORM 有权
    多层药物剂型

    公开(公告)号：EP1781263B1

    公开(公告)日：2008-10-01

    申请号：EP05746448.9

    申请日：2005-05-18

    申请人： Evonik Röhm GmbH

    发明人： PETEREIT, Hans-Ulrich ,  MEIER, Christian

    IPC分类号： A61K9/28

    CPC分类号： A61K9/2846 ,  A61K9/284 ,  A61K9/2886

    摘要： The invention relates to a medicament in a multilayer form, containing a) a core with a pharmaceutical agent, b) an inner coating, 50 to 95 percent by weight of which are composed of a (co)polymer comprising 95 to 100 percent by weight of radically polymerized vinylic monomers with neutral side groups and 0 to 5 percent by weight of monomers with anionic side groups, c) an outer coating made of a copolymer comprising 75 to 95 percent by weight of radically polymerized C 1 to C 4 alkyl esters of acrylic acid or methacrylic acid and 5 to 25 percent by weight of (meth)acrylate monomers with an anionic group in the alkyl radical. Said medicament further contains 5 to 30 percent by weight of common pharmaceutical auxiliaries, particularly emollients. The inventive medicament is characterized in that the inner coating contains 5 to 50 percent by weight of common pharmaceutical auxiliaries which are no expanding agents while the amount of expanding agents provided is less than 5 percent by weight.

    MAKROPORÖSES KUNSTSTOFFPERLENMATERIAL
    6.
    发明公开
    MAKROPORÖSES KUNSTSTOFFPERLENMATERIAL 审中-公开
    万家乐孔塑料制成珠

    公开(公告)号：EP1556427A2

    公开(公告)日：2005-07-27

    申请号：EP03750435.4

    申请日：2003-08-25

    申请人： Röhm GmbH & Co. KG

    发明人： MENZLER, Stefan ,  PETEREIT, Hans-Ulrich ,  MEIER, Christian ,  BOLLER, Thomas ,  SÜFKE, Thomas ,  SCHULTES, Klaus ,  RECKTENWALD, Roger

    IPC分类号： C08F246/00 ,  C08F220/28 ,  C12N11/08

    CPC分类号： C08F220/28 ,  C08F246/00 ,  Y10S530/815

    摘要： The invention concerns a macroporous material in the form of plastic pearls, having an average particle diameter ranging between 10 and 1000 νm, containing a copolymer consisting of: a) 5 to 60 wt. % of monomers capable of being subjected to vinyl polymerization, being at least 1 % water soluble at 20 °C; b) 1 to 40 wt. % of monomers capable of being subjected to vinyl polymerization, comprising an additional functional group capable of being covalently bound to nucleophilic groups of ligands, during a polymerization-like reaction; c) 10 to 40 wt. % of hydrophilic monomers capable of being subjected to a crosslinking free radical polymerization, comprising at least two ethylenically unsaturated polymerisable groups; and d) 10 to 60 wt. % of monomers capable of the subjected to vinyl polymerization, not more than 1 % water soluble at 20 °C, the sum of the monomers a) through d) being generally equal to 100 %.

    ÜBERZUGS- UND BINDEMITTEL FÜR ORALE ODER DERMALE ARZNEIFORMEN
    9.
    发明公开
    ÜBERZUGS- UND BINDEMITTEL FÜR ORALE ODER DERMALE ARZNEIFORMEN 有权
    涂层和结合剂用于口服或皮肤药物

    公开(公告)号：EP1098935A1

    公开(公告)日：2001-05-16

    申请号：EP99931245.7

    申请日：1999-07-02

    申请人： Röhm GmbH

    发明人： PETEREIT, Hans-Ulrich ,  MEIER, Christian ,  ROTH, Erna

    IPC分类号： C08L33/08 ,  C08L33/10 ,  A61K9/28 ,  A61K47/32 ,  A61K9/70

    CPC分类号： A61K9/2846 ,  Y10S524/904

    摘要： The invention relates to a method for the production of a coating and excipient agent for oral or dermal dosage forms, consisting of (a) 35-98 % by weight of a copolymer consisting of radically polymerized C1-C4 esters of acrylic or methacrylic acid and additional (meth)acrylate monomers having functional tertiary ammonium groups and (b) 1-50 % by weight of a softener and 1-15 % by weight of an emulgator with an HLB value of less than 14, wherein constituents (a), (b) and (c) are mixed with or without adding water and optionally adding a pharmaceutical active substance and other conventional additives and the coating and excipient agent is produced by melting, casting, spreading or spraying. The invention is characterized in that the copolymer (a) is applied in powder form with a mean particle size of 1-40 νm.