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    AZNEIFORM UND VERFAHREN IHRER HERSTELLUNG
    2.
    发明公开
    AZNEIFORM UND VERFAHREN IHRER HERSTELLUNG 有权
    药物剂型及其制备方法

    公开(公告)号：EP1478352A1

    公开(公告)日：2004-11-24

    申请号：EP03711870.0

    申请日：2003-01-30

    申请人： Röhm GmbH & Co. KG

    发明人： PETEREIT, Hans-Ulrich ,  SÜFKE, Thomas ,  MEIER, Christian ,  SCHNABEL, Michael ,  BLESING, Ingrid ,  GRIMM, Stefan

    IPC分类号： A61K9/32 ,  A61K9/52 ,  C08F220/18

    CPC分类号： A61K9/5026 ,  A61K9/2846 ,  Y02A50/473

    摘要： The invention relates to a method for producing a pharmaceutical dosage form as tablets, pellets and/or in the form of an active ingredient-containing matrix, whereby the tablets, pellets and/or active ingredient-containing matrix contain a pharmaceutical active ingredient and a copolymer serving as a coating agent and/or binding agent, and optionally contain a core and pharmaceutically common additives. According to the invention, the copolymer, the pharmaceutical active ingredient, the optionally present core and/or the pharmaceutically common additives are processed using known techniques by melting, injection molding, extrusion, wet granulation, casting, dipping, spreading out, spraying on, or pressing to form tablets, pellets and/or an active ingredient-containing matrix. The inventive method is characterized in that a copolymer is used that consists of 20 to 34 wt. % methacrylic acid, 20 to 69 wt. % methylacrylate and 0 to 40 wt. % ethylacrylate and, optionally, of 0 to 10 wt. % of additional vinylically copolymerizable monomers with the provision that the glass transition temperature of the copolymer is no higher than 60° C according to ISO 11357-2, Item 3.3.3. The invention also relates to the pharmaceutical dosage form produced according to this method, said copolymer and the use thereof.

    ARZNEIFORM UND VERFAHREN IHRER HERSTELLUNG
    10.
    发明授权
    ARZNEIFORM UND VERFAHREN IHRER HERSTELLUNG 有权
    药物剂型及其制备方法

    公开(公告)号：EP1478352B1

    公开(公告)日：2006-08-16

    申请号：EP03711870.0

    申请日：2003-01-30

    申请人： Röhm GmbH

    发明人： PETEREIT, Hans-Ulrich ,  SÜFKE, Thomas ,  MEIER, Christian ,  SCHNABEL, Michael ,  BLESING, Ingrid ,  GRIMM, Stefan

    IPC分类号： A61K9/32 ,  A61K9/52 ,  C08F220/18

    CPC分类号： A61K9/5026 ,  A61K9/2846 ,  Y02A50/473

    摘要： The invention relates to a method for producing a pharmaceutical dosage form as tablets, pellets and/or in the form of an active ingredient-containing matrix, whereby the tablets, pellets and/or active ingredient-containing matrix contain a pharmaceutical active ingredient and a copolymer serving as a coating agent and/or binding agent, and optionally contain a core and pharmaceutically common additives. According to the invention, the copolymer, the pharmaceutical active ingredient, the optionally present core and/or the pharmaceutically common additives are processed using known techniques by melting, injection molding, extrusion, wet granulation, casting, dipping, spreading out, spraying on, or pressing to form tablets, pellets and/or an active ingredient-containing matrix. The inventive method is characterized in that a copolymer is used that consists of 20 to 34 wt. % methacrylic acid, 20 to 69 wt. % methylacrylate and 0 to 40 wt. % ethylacrylate and, optionally, of 0 to 10 wt. % of additional vinylically copolymerizable monomers with the provision that the glass transition temperature of the copolymer is no higher than 60 DEG C according to ISO 11357-2, Item 3.3.3. The invention also relates to the pharmaceutical dosage form produced according to this method, said copolymer and the use thereof.