公开(公告)号：EP2070897B1

公开(公告)日：2018-04-18

申请号：EP07806029.0

申请日：2007-08-24

申请人： RIKEN ,  Hamamatsu Photonics K.K.

发明人： SUZUKI, Masaaki ,  DOI, Hisashi ,  TSUKADA, Hideo

IPC分类号： C07C1/32 ,  C07B59/00 ,  C07C11/02 ,  C07C13/20 ,  C07C15/02 ,  C07C15/06 ,  C07C15/08 ,  C07C15/14 ,  C07C17/263 ,  C07C25/02 ,  C07C29/32 ,  C07C33/025 ,  C07C41/30 ,  C07C43/205 ,  C07C67/333 ,  C07C69/533 ,  C07C69/76 ,  C07C201/12 ,  C07C205/06 ,  C07C67/343

CPC分类号： C07B59/001 ,  C07B37/04 ,  C07B59/00 ,  C07B2200/05 ,  C07C1/321 ,  C07C17/263 ,  C07C29/32 ,  C07C41/30 ,  C07C67/343 ,  C07C205/06 ,  C07C2531/24 ,  C07C2601/16 ,  C07C25/13 ,  C07C22/08 ,  C07C33/03 ,  C07C69/76 ,  C07C43/205

摘要： It is intended to provide a method of rapid methylation of an aromatic compound or an alkenyl compound, which is capable of obtaining an aromatic compound or an alkenyl compound labeled with a methyl group or a fluoromethyl group under a mild condition rapidly in high yield using an organic boron compound whose toxicity is not so high as a substrate; a kit for preparing a PET tracer to be used in the same, and a method of producing a PET tracer using the same. In an aprotic polar solvent, methyl iodide or X-CH2F (wherein X is a functional group which can be easily released as an anion), an organic boron compound in which an aromatic ring or an alkenyl group is attached to boron are subjected to cross-coupling in the presence of a palladium(0) complex, a phosphine ligand, and a base.

公开(公告)号：EP2070897A1

公开(公告)日：2009-06-17

申请号：EP07806029.0

申请日：2007-08-24

申请人： Gifu University ,  Riken ,  Hamamatsu Photonics K.K.

发明人： SUZUKI, Masaaki ,  DOI, Hisashi ,  TSUKADA, Hideo

IPC分类号： C07C1/32 ,  C07B59/00 ,  C07C11/02 ,  C07C13/20 ,  C07C15/02 ,  C07C15/06 ,  C07C15/08 ,  C07C15/14 ,  C07C17/263 ,  C07C25/02 ,  C07C29/32 ,  C07C33/025 ,  C07C41/30 ,  C07C43/205 ,  C07C67/333 ,  C07C69/533 ,  C07C69/76 ,  C07C201/12 ,  C07C205/06 ,  G01T1/161

CPC分类号： C07B59/001 ,  C07B37/04 ,  C07B59/00 ,  C07B2200/05 ,  C07C1/321 ,  C07C17/263 ,  C07C29/32 ,  C07C41/30 ,  C07C67/343 ,  C07C205/06 ,  C07C2531/24 ,  C07C2601/16 ,  C07C25/13 ,  C07C22/08 ,  C07C33/03 ,  C07C69/76 ,  C07C43/205

摘要： It is intended to provide a method of rapid methylation of an aromatic compound or an alkenyl compound, which is capable of obtaining an aromatic compound or an alkenyl compound labeled with a methyl group or a fluoromethyl group under a mild condition rapidly in high yield using an organic boron compound whose toxicity is not so high as a substrate; a kit for preparing a PET tracer to be used in the same, and a method of producing a PET tracer using the same. In an aprotic polar solvent, methyl iodide or X-CH2F (wherein X is a functional group which can be easily released as an anion), an organic boron compound in which an aromatic ring or an alkenyl group is attached to boron are subjected to cross-coupling in the presence of a palladium(0) complex, a phosphine ligand, and a base.

摘要翻译： 它的目的是提供一种芳香族化合物或链烯基化合物的高速甲基化的方法，所有这些都能够芳香族化合物或标记有甲基或温和的条件下以高产率使用以氟甲基快速烯基化合物获得的 有机硼化合物是谁的毒性不那么高的底物; 在相同的被使用，一种制备PET示踪剂的试剂盒，和生产用相同的PET示踪剂的方法。 在非质子极性溶剂，甲基碘或X-CH 2 F（worin X是可以很容易地释放，在阴离子的官能团），以芳族环或链烯基，其中有机硼化合物附着于硼需经过匀 - 耦合在钯（0）配合物，膦配体和碱的存在下进行。

公开(公告)号：EP4253954A1

公开(公告)日：2023-10-04

申请号：EP21915120.6

申请日：2021-12-17

申请人： Hamamatsu Photonics K.K.

发明人： OHBA, Hiroyuki ,  TSUKADA, Hideo

IPC分类号： G01N33/50

摘要： The present invention relates to a method for assessing mitochondrial function in a tissue or organ other than the kidney in a test subject, including: a step of calculating a ratio (BUN/CRE) of blood urea nitrogen (BUN) concentration to blood creatinine (CRE) concentration in a test subject; and a step of estimating mitochondrial activity in a tissue or organ other than the kidney in the test subject using the calculated ratio (BUN/CRE).

公开(公告)号：EP2915809B1

公开(公告)日：2017-01-25

申请号：EP13831121.2

申请日：2013-08-22

申请人： Hamamatsu Photonics K.K.

发明人： NISHIYAMA, Shingo ,  HARADA, Norihiro ,  TSUKADA, Hideo

IPC分类号： C07D401/12 ,  A61K51/00 ,  A61K51/04

CPC分类号： C07D401/12 ,  A61K51/0459

公开(公告)号：EP2915809A1

公开(公告)日：2015-09-09

申请号：EP13831121.2

申请日：2013-08-22

申请人： Hamamatsu Photonics K.K.

发明人： NISHIYAMA, Shingo ,  HARADA, Norihiro ,  TSUKADA, Hideo

IPC分类号： C07D401/12 ,  A61K51/00

CPC分类号： C07D401/12 ,  A61K51/0459

摘要： Provided is a compound represented by formula (1-0):

wherein in formula (1-0), R represents -O(CH 2 ) n -, -O(CH 2 ) n OC 2 H 4 -, -CH 2 O(CH 2 ) n - or -CH 2 O(CH 2 ) n OC 2 H 4 -; n represents an integer from 1 to 5; and Q 1 represents F or -OCH 3 .

公开(公告)号：EP3058960A1

公开(公告)日：2016-08-24

申请号：EP14853995.0

申请日：2014-09-18

申请人： Hamamatsu Photonics K.K.

发明人： TSUKADA, Hideo ,  KANAZAWA, Masakatsu ,  HARADA, Norihiro ,  NISHIYAMA, Shingo

IPC分类号： A61K51/00

CPC分类号： A61K51/0459

摘要： The present invention provides a diagnostic agent for a therapeutic effect on cancer, containing a compound represented by formula (1-0).

(In formula (1-0), R represents -O(CH 2 ) n -, -O(CH 2 ) n OC 2 H 4 -, -CH 2 O(CH 2 ) n -, or -CH 2 O(CH 2 ) n OC 2 H 4 -, n represents an integer of 1 to 5, and Q 1 represents F or -OCH 3 .)

摘要翻译： 本发明提供了含有式（1-0）所示化合物的癌症治疗效果的诊断剂。 （式（1-0）中，R表示-O（CH 2）n - ， - O（CH 2）n OC 2 H 4 - ， - CH 2 O（CH 2）n - 或-CH 2 O CH 2）n OC 2 H 4 - ，n表示1〜5的整数，Q 1表示F或-OCH 3）