公开(公告)号：EP0643626B1

公开(公告)日：2002-02-27

申请号：EP92919443.9

申请日：1992-08-26

申请人： Research Corporation Technologies, Inc

发明人： JACOBSEN, Eric, N. ,  ZHANG, Wei ,  DENG, Li

IPC分类号： B01J31/00 ,  C07F9/00 ,  C07F13/00 ,  C07F11/00 ,  C07F15/00 ,  C07D493/00 ,  C07D301/06 ,  C07D301/12 ,  C07D301/14 ,  C07D305/00 ,  C07D493/04 ,  B01J31/18 ,  C07C315/02 ,  C07D305/14 ,  C07D303/48

CPC分类号： B01J31/2243 ,  B01J2231/72 ,  B01J2531/0252 ,  B01J2531/0266 ,  B01J2531/72 ,  C07C315/02 ,  C07D301/12 ,  C07D301/14 ,  C07D305/14 ,  C07D493/04 ,  C07D493/10 ,  C07F13/005

摘要： Chiral catalysts for enantioselectively epoxidizing a prochiral olefin and for enantioselectively oxidizing a prochiral sulfide are disclosed, together with methods of using such catalysts. In accordance with one aspect of the invention, the catalyst is a salen derivative which has general structure (I). In accordance with another aspect of the present invention is a method of producing an epoxychroman using a chiral catalyst. In accordance with this method, a chromene derivative, an oxygen atom source, and a chiral catalyst are reacted under such conditions and for such time as is needed to epoxidize said chromene derivative. In accordance with yet another aspect of this invention is a method of enantioselectively epoxidizing a cis-cinnamate derivative to make taxol or an analog thereof. In accordance with another aspect a method of disproportionation of hydrogen peroxide using the catalysts of the present invention is disclosed.

公开(公告)号：EP0643626A1

公开(公告)日：1995-03-22

申请号：EP92919443.0

申请日：1992-08-26

申请人： RESEARCH CORPORATION TECHNOLOGIES, INC.

发明人： JACOBSEN, Eric, N. ,  ZHANG, Wei ,  DENG, Li

IPC分类号： B01J31 ,  C07C251 ,  C07C315 ,  C07D301 ,  C07D305 ,  C07D493 ,  C07F7 ,  C07F9 ,  C07F11 ,  C07F13 ,  C07F15

CPC分类号： B01J31/2243 ,  B01J2231/72 ,  B01J2531/0252 ,  B01J2531/0266 ,  B01J2531/72 ,  C07C315/02 ,  C07D301/12 ,  C07D301/14 ,  C07D305/14 ,  C07D493/04 ,  C07D493/10 ,  C07F13/005

摘要： Chiral catalysts for enantioselectively epoxidizing a prochiral olefin and for enantioselectively oxidizing a prochiral sulfide are disclosed, together with methods of using such catalysts. In accordance with one aspect of the invention, the catalyst is a salen derivative which has general structure (I). In accordance with another aspect of the present invention is a method of producing an epoxychroman using a chiral catalyst. In accordance with this method, a chromene derivative, an oxygen atom source, and a chiral catalyst are reacted under such conditions and for such time as is needed to epoxidize said chromene derivative. In accordance with yet another aspect of this invention is a method of enantioselectively epoxidizing a cis-cinnamate derivative to make taxol or an analog thereof. In accordance with another aspect a method of disproportionation of hydrogen peroxide using the catalysts of the present invention is disclosed.

公开(公告)号：EP0521099A1

公开(公告)日：1993-01-07

申请号：EP91907292.0

申请日：1991-03-21

申请人： RESEARCH CORPORATION TECHNOLOGIES, INC.

发明人： JACOBSEN, Eric, N. ,  ZHANG, Wei

IPC分类号： C07D301 ,  B01J31 ,  C07B53 ,  C07B61 ,  C07C251 ,  C07D303 ,  C07D493 ,  C07F7 ,  C07F9 ,  C07F11 ,  C07F13 ,  C07F15 ,  C07F19

CPC分类号： B01J31/2243 ,  B01J2231/72 ,  B01J2531/0252 ,  B01J2531/62 ,  B01J2531/72 ,  B01J2531/842 ,  B01J2531/845 ,  B01J2531/847 ,  C07C251/24 ,  C07C2601/14 ,  C07D301/14 ,  C07D303/04 ,  C07D303/48 ,  C07D493/04 ,  C07D493/10 ,  C07F7/0818 ,  C07F7/082 ,  C07F13/005 ,  C07F19/005

摘要： Catalyseurs chiraux destinés à l'époxydation énantio-sélective d'une oléfine prochirale et méthodes d'utilisation de tels catalyseurs. Selon l'une des configurations de l'invention, le catalyseur est un dérivé salen (élaboré à partir d'éthylènediamine) présentant la structure générale (I).

摘要翻译： 公开了用于对映体选择性环氧化前手性烯烃的手性催化剂，以及使用这种催化剂的方法。 根据本发明的一个方面，催化剂是具有一般结构（I）的salen衍生物。