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1.发明公开METHOD AND APPARATUS FOR GENERATION OF MICROPARTICLES CONTAINING IMMOBILIZED ENZYME 审中-公开用于产生含有固定化酶的微粒的方法和设备
公开(公告)号：EP3171862A1
公开(公告)日：2017-05-31
申请号：EP15741210.7
申请日：2015-07-23
发明人： FUERST, Otto , HARTTIG, Herbert , HILLER, Bernd
CPC分类号： C12N11/10 , A61K9/5036 , A61K9/5089 , B05B7/1686 , C12N9/0006 , C12N11/04 , C12Q1/006 , C12Q1/54 , C12Y101/01047 , C12Y101/03004 , G01N33/66
摘要： The invention concerns a method and an apparatus for generation of micropartides containing an immobilized functional component, where the following measures are proposed: —spraying a liquid (32) containing a soluble alginate and a functional component consisting of molecules or nanoparticles to generate a stream (60) of droplets, —directing the stream (60) of droplets onto a precipitation bath (16) and capturing the droplets therein by application of high voltage (14), —precipitating the droplets in the precipitation bath (16) by means of a precipitation liquid (18) containing an alginate complexing agent, such that the droplets are solidified to form micropartides (10) containing the functional component and —extracting the micropartides (10) from the precipitation bath (16).
摘要翻译： 本发明涉及用于产生含有固定化功能组分的微粒的方法和设备，其中提出了以下措施： - 喷射含有可溶藻酸盐和由分子或纳米粒子组成的功能组分的液体（32）以产生流 60）液滴， - 将液滴流（60）引导到沉淀浴（16）上并通过施加高压（14）捕获其中的液滴， - 借助于在沉淀浴（16）中沉淀液滴 包含藻酸盐络合剂的沉淀液（18），使得所述液滴固化以形成含有所述功能组分的微粒（10）并且 - 从所述沉淀浴（16）中提取所述微粒（10）。
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公开(公告)号：EP2194873B1
公开(公告)日：2011-03-02
申请号：EP08803071.3
申请日：2008-08-15
发明人： FUERST, Otto , HAAR, Hans-Peter
IPC分类号： A61B5/151
CPC分类号： A61B5/1411 , A61B5/14532 , A61B5/1455 , A61B5/1468 , A61B5/150022 , A61B5/150282 , A61B5/150419 , A61B5/150427 , A61B5/150435 , A61B5/150519 , A61B5/150755 , A61B5/15115 , A61B5/15142 , A61B5/15153 , A61B5/157 , A61B5/411
摘要： The invention relates to a disposable diagnostic part with a puncturing element (14), which is constructed for puncturing the skin (26) and has a collecting tubule (16) for taking up body fluid, and a detecting element (18), which has a test layer (42) provided with reagents for the detection of an analyte in the body fluid and is disposed in the collecting tubule (16). In order to ensure an improved stability and biocompatibility, it is proposed that the detecting element (18) be provided with a sealing layer (20), which is applied on the test layer (42) and covers the reagents.
摘要翻译： 本发明涉及一种具有穿刺元件（14）的一次性诊断部件，该穿刺元件构造成用于刺穿皮肤（26）并具有用于吸收体液的收集细管（16），以及检测元件（18） 提供有用于检测体液中分析物的试剂的测试层（42），所述测试层设置在所述集合管（16）中。 为了确保改进的稳定性和生物相容性，建议检测元件（18）设置有密封层（20），其被施加在测试层（42）上并覆盖试剂。
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公开(公告)号：EP1725169A2
公开(公告)日：2006-11-29
申请号：EP05715775.2
申请日：2005-03-07
发明人： CALASSO, Irio , GRISS, Patrick , SAROFIM, Emad , JAEGGI, Rainer , KRAEMER, Uwe , HASKER, Dave , ZIMMER, Volker , SCHMID, Wilfried , FUERST, Otto , LIST, Hans , HAAR, Hans-Peter , ARNITZ, Theo , ROE, Steven, N.
IPC分类号： A61B5/15
CPC分类号： A61B5/14532 , A61B5/1411 , A61B5/1486 , A61B5/150022 , A61B5/150251 , A61B5/150297 , A61B5/150358 , A61B5/150419 , A61B5/150435 , A61B5/150503 , A61B5/15107 , A61B5/15117
摘要： Body fluid sampling device comprising a skin-piercing element (1) having a collection zone (9) for receiving body fluid, and the device further comprising a fluid receiving means (10) remote spaced apart from said collection zone so that body fluid in said collection zone will not contact the fluid receiving means initially. Said collection zone takes up a very small volume of body fluid of about 10 to 500 nl in a very short time period of less than 0,5 s. Said fluid receiving means may have a test zone for performing an analytical reaction. Fluid sample from said collection zone is automatically or manually transported to said fluid receiving means to contact said fluid with said test zone.
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公开(公告)号：EP1725169B1
公开(公告)日：2014-04-16
申请号：EP05715775.2
申请日：2005-03-07
发明人： CALASSO, Irio , GRISS, Patrick , SAROFIM, Emad , JAEGGI, Rainer , KRAEMER, Uwe , HASKER, Dave , ZIMMER, Volker , SCHMID, Wilfried , FUERST, Otto , LIST, Hans , HAAR, Hans-Peter , ARNITZ, Theo , ROE, Steven, N.
IPC分类号： A61B5/15
CPC分类号： A61B5/14532 , A61B5/1411 , A61B5/1486 , A61B5/150022 , A61B5/150251 , A61B5/150297 , A61B5/150358 , A61B5/150419 , A61B5/150435 , A61B5/150503 , A61B5/15107 , A61B5/15117
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公开(公告)号：EP2307139A1
公开(公告)日：2011-04-13
申请号：EP09797481.0
申请日：2009-07-13
发明人： FUERST, Otto , HAAR, Hans-Peter
IPC分类号： B01L3/00
CPC分类号： G01N33/525 , B01L3/5023 , B01L2300/0887 , B01L2300/161 , B01L2400/0406 , Y10T156/10 , Y10T428/23986 , Y10T442/20 , Y10T442/2484
摘要： The present invention relates to an analytical testing element comprising a surface designed as a chemical verification layer (14) and a spreading net (16) disposed thereon for the planar distribution of a liquid sample, wherein the spreading net has a filament structure. According to the invention, the spreading net (16) comprises an oxidized metallic layer (20) at least at the surface of the net facing the verification layer (14).
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6.发明公开
公开(公告)号：EP2034911A1
公开(公告)日：2009-03-18
申请号：EP07726111.3
申请日：2007-06-21
发明人： LIST, Hans , FUERST, Otto , HAAR, Hans-Peter , HAUETER, Ulrich , HARTTIG, Herbert , PILL, Johannes
CPC分类号： A61B17/3421 , A61B5/0002 , A61B5/14865 , A61B5/6848 , A61B17/3417 , A61B17/3468 , A61B2017/2905 , A61B2017/3405 , A61B2017/3492
摘要： Disclosed is a device that is to be introduced into a body and comprises a distal region which is provided with a tip zone for creating an opening in the skin, and a segmented area which encompasses at least two subareas. Said subareas are connected at least to one another and to the distal region in an essentially rigid manner in a rigid state while being movable towards each other in a flexible state. Also disclosed is a system in which a sensor is integrated into the inventive device that is to be introduced into a body.
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公开(公告)号：EP2396113B1
公开(公告)日：2016-03-30
申请号：EP10706571.6
申请日：2010-02-12
发明人： HARTTIG, Herbert , ROEPER, Josef , FUERST, Otto , JAECK, Thomas , DAGENBACH, Ralf , BRAUN, Jürgen , MÖNCH, Ronald , LIST, Hans , KOSCHORRECK, Beate
IPC分类号： B01L3/00 , G01N33/487
CPC分类号： G01N33/48764 , B01L3/5023 , B01L2200/12 , B01L2300/0825 , B01L2300/0887 , G01N21/898
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公开(公告)号：EP2396113A1
公开(公告)日：2011-12-21
申请号：EP10706571.6
申请日：2010-02-12
发明人： HARTTIG, Herbert , ROEPER, Josef , FUERST, Otto , JAECK, Thomas , DAGENBACH, Ralf , BRAUN, Jürgen , MÖNCH, Ronald , LIST, Hans , KOSCHORRECK, Beate
IPC分类号： B01L3/00 , G01N33/487
CPC分类号： G01N33/48764 , B01L3/5023 , B01L2200/12 , B01L2300/0825 , B01L2300/0887 , G01N21/898
摘要： The invention relates to a diagnostic test strip for liquid samples comprising a flexible conveyor strip (12) and a plurality of test fields (14) attached to the conveyor strip (12) so as to be distributed in the longitudinal direction of the strip, wherein the test fields comprise a detection layer (18) and a spreading net covering the detection layer (18) for accommodating liquid samples over the area thereof, wherein the spreading net is composed of a grid-like woven fabric (20) having woven-fabric threads (28, 30) that cross at right angles. In order to avoid bulging of the woven fabric under strip tension, it is proposed that the woven fabric (20) be oriented at an angle to the conveyor strip (12) so that all woven-fabric threads (28, 30) extend at an angle to the longitudinal direction of the strip.
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9.发明授权
公开(公告)号：EP2034911B1
公开(公告)日：2010-10-13
申请号：EP07726111.3
申请日：2007-06-21
发明人： LIST, Hans , FUERST, Otto , HAAR, Hans-Peter , HAUETER, Ulrich , HARTTIG, Herbert , PILL, Johannes
CPC分类号： A61B17/3421 , A61B5/0002 , A61B5/14865 , A61B5/6848 , A61B17/3417 , A61B17/3468 , A61B2017/2905 , A61B2017/3405 , A61B2017/3492
摘要： Disclosed is a device that is to be introduced into a body and comprises a distal region which is provided with a tip zone for creating an opening in the skin, and a segmented area which encompasses at least two subareas. Said subareas are connected at least to one another and to the distal region in an essentially rigid manner in a rigid state while being movable towards each other in a flexible state. Also disclosed is a system in which a sensor is integrated into the inventive device that is to be introduced into a body.
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10.发明公开DIAGNOSTISCHES EINMALTEIL UND VERFAHREN ZU SEINER HERSTELLUNG 有权诊断EINMALTEIL UND VERFAHREN ZU SEINER HERSTELLUNG
公开(公告)号：EP2194873A1
公开(公告)日：2010-06-16
申请号：EP08803071.3
申请日：2008-08-15
发明人： FUERST, Otto , HAAR, Hans-Peter
IPC分类号： A61B5/151
CPC分类号： A61B5/1411 , A61B5/14532 , A61B5/1455 , A61B5/1468 , A61B5/150022 , A61B5/150282 , A61B5/150419 , A61B5/150427 , A61B5/150435 , A61B5/150519 , A61B5/150755 , A61B5/15115 , A61B5/15142 , A61B5/15153 , A61B5/157 , A61B5/411
摘要： The invention relates to a disposable diagnostic part with a puncturing element (14), which is constructed for puncturing the skin (26) and has a collecting tubule (16) for taking up body fluid, and a detecting element (18), which has a test layer (42) provided with reagents for the detection of an analyte in the body fluid and is disposed in the collecting tubule (16). In order to ensure an improved stability and biocompatibility, it is proposed that the detecting element (18) be provided with a sealing layer (20), which is applied on the test layer (42) and covers the reagents.
摘要翻译： 本发明涉及一种具有穿刺元件（14）的一次性诊断部件，该穿刺元件构造成用于刺穿皮肤（26）并具有用于吸收体液的收集细管（16），以及检测元件（18） 提供有用于检测体液中分析物的试剂的测试层（42），所述测试层设置在所述集合管（16）中。 为了确保改进的稳定性和生物相容性，建议检测元件（18）设置有密封层（20），其被施加在测试层（42）上并覆盖试剂。
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