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    STABILIZATION OF ENZYMES BY NICOTINIC ACID
    3.
    发明公开
    STABILIZATION OF ENZYMES BY NICOTINIC ACID 有权
    镇定酶烟碱酸的

    公开(公告)号：EP2994536A1

    公开(公告)日：2016-03-16

    申请号：EP14722216.0

    申请日：2014-05-08

    申请人： Roche Diagnostics GmbH ,  F.Hoffmann-La Roche AG

    发明人： CHEMNITIUS, Gabriele ,  NAGEL, Thomas ,  GAA, Otto ,  RECHT, Karl ,  MEIER, Thomas

    IPC分类号： C12Q1/00 ,  C12Q1/32 ,  C12N9/96 ,  G01N33/52

    CPC分类号： C12N9/96 ,  C12N9/0006 ,  C12Q1/006 ,  C12Q1/32 ,  C12Y101/01 ,  C12Y101/9901 ,  G01N33/523 ,  G01N33/526 ,  G01N2333/904

    摘要： The present invention is concerned with means and methods for maintaining and preserving enzymatic activity. In particular, the invention relates to a dry composition comprising a dehydrogenase, a redox cofactor, an agent capable of eliciting at least one measurable change in a property of an indicator reagent in the presence of redox equivalents, an indicator reagent, and at least one pyridine-carboxylic acid or a derivative or salt thereof. The invention further contemplates a diagnostic test element for the determination of an analyte from a body fluid sample and a method for the manufacture of such a test element. Further envisaged by the present invention is the use of a pyridine-carboxylic acid or a derivative thereof for reducing a decrease of the enzymatic activity of at least one enzyme in a composition under dry and/or under humid conditions. Furthermore, contemplated is a method for determining the presence or amount analyte in a body fluid sample based on the test element according to the invention.

    COMPATIBLE SOLUTE ECTOINE AS WELL AS DERIVATIVES THEREOF FOR ENZYME STABILIZATION
    4.
    发明公开
    COMPATIBLE SOLUTE ECTOINE AS WELL AS DERIVATIVES THEREOF FOR ENZYME STABILIZATION 有权
    兼容解决ECTOIN及其衍生物的酶稳定化

    公开(公告)号：EP2823052A1

    公开(公告)日：2015-01-14

    申请号：EP13707185.8

    申请日：2013-03-05

    申请人： Roche Diagnostics GmbH ,  F.Hoffmann-La Roche AG

    发明人： CHEMNITIUS, Gabriele ,  GAA, Otto ,  NAGEL, Thomas ,  RECHT, Karl

    IPC分类号： C12Q1/32

    CPC分类号： C12Q1/32 ,  G01N2333/902

    摘要： The present invention is concerned with means and methods for maintaining and preserving enzymatic activity. In particular, the invention relates to a dry composition comprising a dehydrogenase, a redox cofactor, an agent capable of eliciting at least one optical change in an optical property of an indicator reagent in the presence of redox equivalents, an indicator reagent, and at least one compatible solute being ectoine or a derivative thereof. The invention further contemplates a diagnostic test element for the determination of an analyte from a body fluid sample and a method for the manufacture of such a test element. Further envisaged by the present invention is the use of at least one compatibie solute as mentioned above for reducing a decrease of the enzymatic activity of at least one enzyme in a composition under dry conditions. Furthermore, contemplated is a method for determining the presence or amount analyte in a body fluid sample based on the test element according to the invention.