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公开(公告)号：EP3347478A1
公开(公告)日：2018-07-18
申请号：EP15790654.6
申请日：2015-09-10
申请人： Metabolic Explorer
CPC分类号： C12N9/0006 , C12P7/18 , C12R1/19 , C12Y101/01 , C12Y101/01077 , C12Y101/01283 , C12Y208/03017 , C12Y402/03003 , C12Y404/01005 , C12Y501/02001
摘要： The present invention relates to new lactaldehyde reductase (LAR) enzymes useful for the production of 1,2-propane-diol and to microorganisms overexpressing said enzymes. The invention also relates to a method for producing 1,2-propanediol by converting lactaldehyde into 1,2-propanediol with said enzymes.
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公开(公告)号：EP3241894A1
公开(公告)日：2017-11-08
申请号：EP17172469.3
申请日：2011-04-19
申请人： DSM IP Assets B.V.
发明人： KLAASSEN, Paul , GIELESEN, Bianca Elisabeth Maria , VAN SUYLEKOM, Gijsberdina Pieternella , HEIJNE, Wilbert Herman Marie
IPC分类号： C12N1/36 , C07K14/395
CPC分类号： C12P7/10 , C07K14/395 , C12N1/36 , C12N9/0004 , C12N9/0006 , C12N9/10 , C12N9/1205 , C12N9/16 , C12N9/2405 , C12N9/2411 , C12N9/2437 , C12N9/2468 , C12N9/248 , C12N9/50 , C12N9/88 , C12N9/90 , C12N9/92 , C12P5/026 , C12P7/16 , C12P7/18 , C12P7/20 , C12P7/40 , C12P7/42 , C12P7/44 , C12P7/46 , C12P7/48 , C12P7/54 , C12P7/56 , C12P13/005 , C12P13/08 , C12P13/12 , C12P13/20 , C12P13/227 , C12P17/10 , C12P35/00 , C12Y101/01 , C12Y207/01016 , C12Y501/03004 , C12Y503/01004 , Y02E50/16 , Y02E50/17 , Y02E50/343
摘要： The present invention relates to a cell suitable for production of one or more fermentation product from a sugar composition comprising glucose, galactose, arabinose and xylose, wherein the cell comprises two to fifteen copies of one or more xylose isomerase gene or two to fifteen copies of one or more xylose reductase and xylitol dehydrogenase, and two to ten copies of araA, araB and araD, genes, wherein these genes are integrated into the cell genome.
摘要翻译： 本发明涉及适于从包含葡萄糖，半乳糖，阿拉伯糖和木糖的糖组合物生产一种或多种发酵产物的细胞，其中所述细胞包含2-15个拷贝的一个或多个木糖异构酶基因或2-15个拷贝的 一种或多种木糖还原酶和木糖醇脱氢酶，以及2至10个拷贝的araA，araB和araD基因，其中这些基因被整合到细胞基因组中。
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公开(公告)号：EP2561064B1
公开(公告)日：2017-10-18
申请号：EP11714788.4
申请日：2011-04-19
申请人： DSM IP Assets B.V.
发明人： KLAASSEN, Paul , GIELESEN, Bianca Elisabeth Maria , SUYLEKOM, VAN, Gijsberdina Pieternella , HEIJNE, Wilbert Herman Marie
IPC分类号： C12N1/36 , C07K14/395
CPC分类号： C12P7/10 , C07K14/395 , C12N1/36 , C12N9/0004 , C12N9/0006 , C12N9/10 , C12N9/1205 , C12N9/16 , C12N9/2405 , C12N9/2411 , C12N9/2437 , C12N9/2468 , C12N9/248 , C12N9/50 , C12N9/88 , C12N9/90 , C12N9/92 , C12P5/026 , C12P7/16 , C12P7/18 , C12P7/20 , C12P7/40 , C12P7/42 , C12P7/44 , C12P7/46 , C12P7/48 , C12P7/54 , C12P7/56 , C12P13/005 , C12P13/08 , C12P13/12 , C12P13/20 , C12P13/227 , C12P17/10 , C12P35/00 , C12Y101/01 , C12Y207/01016 , C12Y501/03004 , C12Y503/01004 , Y02E50/16 , Y02E50/17 , Y02E50/343
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4.发明公开POLYUNSATURATED FATTY ACID SYNTHASE NUCLEIC ACID MOLECULES AND POLYPEPTIDES, COMPOSITIONS, AND METHODS OF MAKING AND USES THEREOF 审中-公开多不饱和脂肪酸合成酶核酸分子和多肽，组合物及其制备和使用方法
公开(公告)号：EP3192871A1
公开(公告)日：2017-07-19
申请号：EP17153399.5
申请日：2010-03-19
申请人： DSM IP Assets B.V.
发明人： APT, Kirk E. , RICHTER, Leslie , SIMPSON, David , ZIRKLE, Ross
CPC分类号： C12N15/52 , A61K38/00 , C12N9/0006 , C12N9/001 , C12N9/1029 , C12N9/88 , C12N15/8247 , C12P7/6427 , C12P7/6472 , C12Y101/01 , C12Y103/01 , C12Y203/01039 , C12Y203/01041 , C12Y402/01 , C12Y402/01059 , Y02P20/52
摘要： The present invention is directed to isolated nucleic acid molecules and polypeptides of thraustochytrid polyunsaturated fatty acid (PUFA) synthases involved in the production of the PUFAs, including PUFAs enriched in docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), or a combination thereof. The present invention is directed to vectors and host cells comprising the nucleic acid molecules, polypeptides encoded by the nucleic acid molecules, compositions comprising the nucleic acid molecules or polypeptides, and methods of making and uses thereof.
摘要翻译： 本发明涉及涉及生产PUFA的破囊壶菌多不饱和脂肪酸（PUFA）合酶的分离的核酸分子和多肽，包括富含二十二碳六烯酸（DHA），二十碳五烯酸（EPA）或其组合的PUFA。 本发明涉及包含核酸分子，由核酸分子编码的多肽，包含核酸分子或多肽的组合物的载体和宿主细胞，以及其制备和使用方法。
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5.发明授权POLYUNSATURATED FATTY ACID SYNTHASE NUCLEIC ACID MOLECULES AND POLYPEPTIDES, COMPOSITIONS, AND METHODS OF MAKING AND USES THEREOF 有权FOR其生产和使用的核酸分子和多肽从PUFA合酶，组合物和方法
公开(公告)号：EP2408797B1
公开(公告)日：2017-03-15
申请号：EP10754185.6
申请日：2010-03-19
申请人： DSM IP Assets B.V.
发明人： APT, Kirk, E. , RICHTER, Leslie , SIMPSON, David , ZIRKLE, Ross
CPC分类号： C12N15/52 , A61K38/00 , C12N9/0006 , C12N9/001 , C12N9/1029 , C12N9/88 , C12N15/8247 , C12P7/6427 , C12P7/6472 , C12Y101/01 , C12Y103/01 , C12Y203/01039 , C12Y203/01041 , C12Y402/01 , C12Y402/01059 , Y02P20/52
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公开(公告)号：EP2898082A1
公开(公告)日：2015-07-29
申请号：EP13773490.1
申请日：2013-09-20
申请人： Bioamber Inc.
CPC分类号： C12P13/001 , C12N9/0006 , C12N9/001 , C12N9/1029 , C12N9/1096 , C12N9/13 , C12N9/16 , C12N9/88 , C12P7/18 , C12P7/40 , C12P7/44 , C12P13/005 , C12Y101/01 , C12Y103/01 , C12Y103/08 , C12Y206/01 , C12Y208/03 , C12Y301/02 , C12Y402/01
摘要： Recombinant microorganisms comprising at least one exogenous nucleic acid sequence and capable of producing adipate semialdehyde are provided. Adipate semialdehyde may be produced in a synthesis pathway utilizing a single thiolase reaction. Adipate semialdehyde may also be produced from intermediates consisting of alpha, omega difunctional aliphatic organic molecules. Methods of using recombinant microorganisms to produce 6-aminocaproic acid, adipic acid, hexamethylenediamine and 1.6-hexanediol are also provided.
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7.发明公开YEAST MICROORGANISMS WITH REDUCED BY-PRODUCT ACCUMULATION FOR IMPROVED PRODUCTION OF FUELS, CHEMICALS, AND AMINO ACIDS 审中-公开具有减少，产品集聚酵母微生物为燃料，化学品和氨基酸提高了生产
公开(公告)号：EP2534240A4
公开(公告)日：2014-04-16
申请号：EP11780955
申请日：2011-02-11
申请人： GEVO INC , CALIFORNIA INST OF TECHN
发明人： BUELTER THOMAS , HAWKINS ANDREW , PORTER-SCHEINMAN STEPHANIE , MEINHOLD PETER , DUNDON CATHERINE ASLESON , ARISTIDOU ARISTOS , URANO JUN , LIES DOUG , PETERS MATTHEW , DEY MELISSA , JANCAUSKAS JUSTAS , BERRY RUTH , EVANS KENT , KELLY JULIE , BASTIAN SABINE , ARNOLD FRANCES
CPC分类号： C12N15/81 , C12N9/0006 , C12P7/16 , C12Y101/01 , C12Y102/01005 , Y02E50/10 , Y02P20/52
摘要： The present invention relates to recombinant microorganisms comprising biosynthetic pathways and methods of using said recombinant microorganisms to produce various beneficial metabolites. In various aspects of the invention, the recombinant microorganisms may further comprise one or more modifications resulting in the reduction or elimination of 3 keto-acid (e.g., acetolactate and 2-aceto-2-hydroxybutyrate) and/or aldehyde-derived by-products. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the Saccharomyces clade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.
摘要翻译： 本发明涉及重组微生物，其包括生物合成途径和使用重组所述微生物以产生各种有益的代谢物的方法。 在本发明的各个方面，所述重组微生物可以进一步包含一个或多个修饰以减少或消除的3酮酸所得的（例如，乙酰乳酸和2-乙酰基-2-羟基丁酸酯）和/或醛衍生的副产物 ， 中描述的各种实施方案中，所述重组微生物可以是酿酒进化枝的微生物，克拉布特里阴性酵母微生物，Crabtree-阳性酵母微生物，后-WGD（全基因组倍增）酵母微生物，预WGD（全基因组倍增）酵母微生物 和非发酵酵母微生物。
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公开(公告)号：EP2576500A2
公开(公告)日：2013-04-10
申请号：EP11728793.8
申请日：2011-06-03
申请人： Chemo Iberica, S.A.
发明人： TADDEI, Maurizio , RUSSO, Adele , CINI, Elena , RIVA, Renata , RASPARINI, Marcello , CARCONE, Luca , BANFI, Luca , VITALE, Romina , ROSEBLADE, Stephen , ZANOTTI-GEROSA, Antonio Carlo
IPC分类号： C07C231/14 , C07C237/20 , C07C69/66 , C07C67/307 , C07D263/08 , C07D307/32
CPC分类号： C07C231/14 , C07B2200/07 , C07C67/00 , C07C67/30 , C07C67/303 , C07C67/343 , C07C231/18 , C07C269/02 , C07D263/22 , C07D263/24 , C07D307/33 , C12P7/00 , C12P7/24 , C12P7/40 , C12P13/02 , C12P41/002 , C12P41/005 , C12Y101/01 , C12Y301/01001 , Y02P20/52 , C07C69/734 , C07C69/738 , C07C237/22 , C07C271/22
摘要： A new route of synthesis of the compound Aliskiren of formula (I), used in the treatment of hypertension, is described.
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9.发明公开
公开(公告)号：EP1940456A4
公开(公告)日：2009-10-21
申请号：EP06825457
申请日：2006-10-04
发明人： CROCE CARLO M , FABBRI MULLER , TRAPASSO FRANCESCO
CPC分类号： A61K38/443 , A61K48/005 , A61K48/0075 , C12N15/86 , C12N2710/10343 , C12Y101/01
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公开(公告)号：EP4368732A3
公开(公告)日：2024-08-28
申请号：EP24165738.6
申请日：2020-07-08
发明人： HONG, Hao , JAMES, Gage , XIAO, Yi , ZHANG, Na , LIU, Fang , WANG, Zujian , SHI, Wanming , YAN, Junjie , ZHANG, Mujiao
CPC分类号： C12N9/0004 , C12N15/70 , C12P7/02 , C12Y101/01 , C12R2001/1920210501
摘要： Provided is a ketoreductase mutant and applications thereof. Compared with an amino acid sequence shown in SEQ ID NO: 1, the amino acid sequence of the ketoreductase mutant includes at least one of the following mutation sites: L198P, S96W/I/L/V, M194L or L1526, herein "/" means "or." The ketoreductase mutant provides high selectivity and high activity with respect to a substrate ketone, and the application of the mutant in a catalytic reduction reaction of a ketone substrate may increase the production efficiency of a chiral alcohol compound corresponding thereto.
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