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    Imaging fluorescence signals using telecentricity
    1.
    发明公开
    Imaging fluorescence signals using telecentricity 有权
    Fluoreszenzabbildung mittelsTelezentrizität

    公开(公告)号：EP1681556A1

    公开(公告)日：2006-07-19

    申请号：EP05000863.0

    申请日：2005-01-18

    申请人： Roche Diagnostics GmbH ,  F.HOFFMANN-LA ROCHE AG

    发明人： Gutekunst, Martin ,  Guse, Frank ,  Heckmann, Hans-Georg ,  Hessling, Martin ,  Koenig, Joachim

    IPC分类号： G01N21/64

    CPC分类号： G01N21/6456 ,  G01J3/02 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/4406 ,  G01N21/6428 ,  G01N21/6452 ,  G01N35/028 ,  G01N2021/6478 ,  G01N2035/00158

    摘要： The present invention relates to the field of DNA analysis. In particular, the present invention is directed to a device for the parallel imaging of fluorescence intensities at a plurality of sites as a measure for DNA hybridization. More particular, the present invention is directed to a device to image multiplex real time PCR or to read out DNA microarrays.
    According to a preferred embodiment the device comprises holding means (1) for holding a planar support (2) with an assembly of multiple individual sites (3); at least one light source (4) for emitting light comprising at least one excitation frequency; a transducer (5) for receiving fluorescence signals from said sites; a field lens (6); an excitation lens arrangement (10), and an imaging lens arrangement (11), wherein said excitation light path and said fluorescence imaging light path are telecentric on the object side of said field lens and wherein the angle of incidence of the excitation light with said planar support is larger than 0°.

    摘要翻译： 本发明涉及DNA分析领域。 特别地，本发明涉及用于在多个位点处的荧光强度的平行成像作为DNA杂交的量度的装置。 更具体地，本发明涉及一种用于对多重实时PCR进行成像或读出DNA微阵列的装置。 根据优选实施例，该装置包括用于用多个单独位置（3）的组件保持平面支撑件（2）的保持装置（1）。 用于发射包括至少一个激发频率的光的至少一个光源（4） 用于从所述位置接收荧光信号的换能器（5） 场透镜（6）; 激励透镜装置（10）和成像透镜装置（11），其中所述激发光路和所述荧光成像光路在所述场透镜的物体侧是远心的，并且其中所述激发光与所述激光 平面支撑大于0°。

    Imaging fluorescence signals using telecentric optics on the excitation and the imaging side
    4.
    发明公开
    Imaging fluorescence signals using telecentric optics on the excitation and the imaging side 有权
    Fluoreszenzabbildung mittels telezentrischer Optiken auf Anregungs- und Abbildungsseite

    公开(公告)号：EP1681558A1

    公开(公告)日：2006-07-19

    申请号：EP06000788.7

    申请日：2006-01-14

    申请人： Roche Diagnostics GmbH ,  F.HOFFMANN-LA ROCHE AG

    发明人： Gutekunst, Martin ,  Guse, Frank ,  Heckmann, Hans-Georg ,  Hessling, Martin ,  Koenig, Joachim

    IPC分类号： G01N21/64

    CPC分类号： G01N21/6428 ,  G01N21/6452 ,  G01N21/6456 ,  G01N21/76 ,  G01N2021/6478 ,  G01N2201/0631

    摘要： The present invention relates to the field of DNA analysis. In particular, the present invention is directed to a device for the parallel imaging of fluorescence intensities at a plurality of sites as a measure for DNA hybridization. More particular, the present invention is directed to a device to image multiplex real time PCR or to read out DNA microarrays.
    According to a preferred embodiment the device comprises holding means (1) for holding a planar support (2) with an assembly of multiple individual sites (3); at least one light source (4) for emitting light comprising at least one excitation frequency; a transducer (5) for receiving fluorescence signals from said sites; a field lens (6); an excitation lens arrangement (10), and an imaging lens arrangement (11), wherein said excitation path and said fluorescence imaging light path are telecentric on the object side of said field lens and wherein the angle of indidence of the excitation light with said planar support is larger than 0°.

    摘要翻译： 本发明涉及DNA分析领域。 特别地，本发明涉及用于在多个位点处的荧光强度的平行成像作为DNA杂交的量度的装置。 更具体地，本发明涉及一种用于对多重实时PCR进行成像或读出DNA微阵列的装置。 根据优选实施例，该装置包括用于用多个单独位置（3）的组件保持平面支撑件（2）的保持装置（1）。 用于发射包括至少一个激发频率的光的至少一个光源（4） 用于从所述位置接收荧光信号的换能器（5） 场透镜（6）; 激励透镜装置（10）和成像透镜装置（11），其中所述激发路径和所述荧光成像光路在所述场透镜的物体侧是远心的，并且其中所述激发光与所述平面 支持大于0°。