利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

10 条记录 (耗时 0.014 秒)

    IMPROVEMENT OF THE SENSITIVITY AND THE DYNAMIC RANGE OF PHOTOMETRIC ASSAYS BY GENERATING MULTIPLE CALIBRATION CURVES
    1.
    发明公开
    IMPROVEMENT OF THE SENSITIVITY AND THE DYNAMIC RANGE OF PHOTOMETRIC ASSAYS BY GENERATING MULTIPLE CALIBRATION CURVES 有权
    改善光度检测的灵敏度和动态范围通过在生产几种校准曲线

    公开(公告)号：EP2841918A1

    公开(公告)日：2015-03-04

    申请号：EP13721303.9

    申请日：2013-04-25

    申请人： Roche Diagnostics GmbH ,  F.Hoffmann-La Roche AG

    发明人： BRUECKNER, Thorsten ,  LOPEZ-CALLE, Eloisa ,  ORANTH, Norbert ,  ROEDL, Josef

    IPC分类号： G01N21/17 ,  G01N21/25 ,  G01N33/53 ,  G01N21/53

    CPC分类号： G01N33/54393 ,  G01D18/00 ,  G01N21/274 ,  G01N21/63 ,  G01N21/78 ,  G01N21/82 ,  G01N33/52 ,  G01N33/54313 ,  G01N33/54346 ,  G01N33/573 ,  G01N33/6827 ,  G01N33/92 ,  G01N2021/825 ,  G06F19/18 ,  G16H50/30

    摘要： The present invention relates to a method for determining the amount of the specific analyte of a sample which may show interferences by photometric assays, wherein the specific analyte is quantified from the change in the optical signal of the reaction mixture after the interaction of the analyte with analyte specific assay reagents. Multiple calibration curves are generated for multiple wavelengths for the specific analyte of a sample to be determined, the measurement results are deposited in a data management system of the instrument platform. An interference test is performed simultaneously to the determination of the specific analyte, for quantifying the amount of interfering substances present in the sample to be determined. The amount of each interfering substances is compared to predetermined cut-off values. The optical signal for the specific analyte of a sample to be determined is measured in the reaction mixture at multiple wavelengths over the complete reaction time, and a calibration curve is selected depending on the interfering substances. Finally, the amount of the specific analyte of a sample to be determined is quantified by comparison with the selected calibration curve for the chosen wavelengths.

    摘要翻译： 本发明涉及一种可显示通过光度测定法干扰，worin所述特定分析物的样品的特定分析物的量是从反应混合物中的光信号的变化的分析物与所述相互作用后定量为确定性采矿的方法 分析物特异性检测试剂。 多个校准曲线为多个波长对样品是确定性的开采的特定分析物产生的，测量结果被沉积在仪器平台的数据管理系统。 干扰测试同时进行的特定分析物的确定用于定量干扰存在于样品中是确定性的开采的物质的量。 各干扰物质的量进行比较，预定截止值。 用于样品的特定分析物的光信号是确定性的开采在在整个反应时间的多个波长的反应混合物进行测定，以及校准曲线被选择取决于干扰物质。 最后，样品的特定分析物的量是确定的开采通过与用于所选择的波长选择的校准曲线进行比较来定量。

    BLOOD COLLECTOR WITH CAPILLARY STRUCTURE
    4.
    发明公开
    BLOOD COLLECTOR WITH CAPILLARY STRUCTURE 审中-公开
    具有毛细结构的血液收集器

    公开(公告)号：EP3184158A1

    公开(公告)日：2017-06-28

    申请号：EP15201585.5

    申请日：2015-12-21

    申请人： Roche Diagnostics GmbH ,  F. Hoffmann-La Roche AG

    发明人： BOEHM, Christoph ,  BRUECKNER, Thorsten ,  LUTZ, Sascha ,  ESROM, Bruntje ,  MICHAEL, Herbel

    IPC分类号： B01D17/02 ,  B01L3/00 ,  G01N33/49 ,  A61B5/15 ,  A61B5/157 ,  A61B10/00

    CPC分类号： G01N1/4077 ,  A61B5/1411 ,  A61B5/150022 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150343 ,  A61B5/150358 ,  A61B5/150755 ,  A61B5/150832 ,  A61B5/157 ,  A61B10/0045 ,  B01D17/0217 ,  B01L3/5021 ,  B01L3/502753 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2200/0631 ,  B01L2200/10 ,  B01L2300/043 ,  B01L2300/0803 ,  B01L2300/123 ,  B01L2400/0406 ,  B01L2400/0409 ,  G01N21/07 ,  G01N21/84 ,  G01N33/491 ,  G01N2001/4083

    摘要： The invention provides for a method of determining an amount of an analyte in a blood sample (500) using a cartridge (100, 300, 600) and a blood collector (400, 800, 1200, 1513). The blood collector comprises: a mounting surface (402); a capillary structure (404) for holding the blood sample, wherein the capillary structure comprises a curved portion (406); a capillary inlet (403) for receiving the blood sample. The cartridge comprises: a receiving surface for attaching to the mounting surface; a cartridge inlet (108) for receiving the blood sample from the blood collector; a microfluidic structure (111) for processing the blood sample into a processed sample; a measurement structure (130) for enabling measurement of the processed sample to determine the amount of the analyte in the blood sample; wherein the method comprises: placing (1100, 1400) the blood sample into the capillary inlet; attaching (1104, 1404) the mounting surface to the receiving surface; rotating (1600) the cartridge about the rotational axis to transport the blood sample from the capillary structure to the cartridge inlet; rotating (1602) the cartridge about the rotational axis to transport the blood sample from the cartridge inlet into the microfluidic structure; controlling (1604) the rotation of the cartridge about the rotational axis to process the blood sample into the processed sample using the microfluidic structure; controlling (1606) the rotation of the cartridge to transfer the processed sample to the measurement structure; and measuring (1608) the amount of the analyte using the measurement structure and a measurement system.

    摘要翻译： 本发明提供了一种使用药筒（100,300,600）和血液收集器（400,800,1200,1513）确定血液样本（500）中的分析物的量的方法。 血液采集器包括：安装表面（402）; 毛细结构（404），其用于保持血样，其中所述毛细结构包括弯曲部分（406）; 毛细管入口（403），用于接收血液样本。 盒包括：用于附接到安装表面的接收表面; 药筒入口（108），用于从血液收集器接收血液样本; 用于将血液样本处理成处理后的样本的微流体结构（111） 测量结构（130），用于能够测量处理后的样品以确定血液样品中分析物的量; 其中该方法包括：将血样放置（1100,1400）到毛细管入口中; 将所述安装表面附接（1104,1404）到所述接收表面; 围绕所述旋转轴旋转（1600）所述盒以将所述血液样品从所述毛细结构传送到所述盒入口; 使所述盒围绕所述旋转轴线旋转（1602）以将所述血液样品从所述盒入口输送到所述微流体结构中; 使用所述微流体结构控制（1604）所述盒绕所述旋转轴线的旋转以将所述血液样本处理成所述处理过的样本; 控制（1606）盒的旋转以将处理后的样本传送到测量结构; 和使用测量结构和测量系统测量（1608）分析物的量。