公开(公告)号：EP1679310A4

公开(公告)日：2008-10-29

申请号：EP04773615

申请日：2004-09-29

申请人： SANKYO CO ,  RENASCIENCE CO LTD

发明人： YANAGISAWA HIROAKI ,  AMEMIYA YOSHIYA ,  KUROKAWA KIYOSHI ,  MIYATA TOSHIO

IPC分类号： C07D257/04 ,  A61K31/41 ,  A61K31/426 ,  A61K31/437 ,  A61K31/4709 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/541 ,  A61K31/5415 ,  A61P3/10 ,  A61P13/12 ,  C07D277/34 ,  C07D401/10 ,  C07D405/12 ,  C07D413/10 ,  C07D417/10 ,  C07D471/04

CPC分类号： C07D277/34 ,  A61K31/41 ,  A61K31/426 ,  A61K31/437 ,  A61K31/4709 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/541 ,  A61K31/5415 ,  C07D257/04 ,  C07D401/10 ,  C07D413/10 ,  C07D417/10 ,  C07D471/04

摘要： Disclosed are a compound represented by the following general formula (I): (I) (wherein A represents a cyclic ring or the like; B represents 1H-tetrazole-5-yl group or 2,4-dioxothiazolidine-5-yl group; and Y represents a single bond or a C6-10 arylene group), or a pharmacologically acceptable salt or ester thereof.

公开(公告)号：EP2189537A4

公开(公告)日：2010-08-11

申请号：EP08792016

申请日：2008-07-31

申请人： UNIV TOKAI EDUCATIONAL SYSTEM ,  TOKYO METROPOLITAN ORG MED RES ,  RENASCIENCE CO LTD ,  MEDICAL & BIOL LAB CO LTD

发明人： ITOKAWA MASANARI ,  MIYATA TOSHIO ,  ARAI MAKOTO

IPC分类号： C12Q1/68 ,  A61K31/415 ,  A61K31/4152 ,  A61K31/437 ,  A61K31/4415 ,  A61K31/4439 ,  A61K45/00 ,  A61P25/18 ,  C12N15/09 ,  G01N30/88 ,  G01N33/15 ,  G01N33/50

CPC分类号： C12Q1/527 ,  A61K31/415 ,  A61K31/4152 ,  A61K31/437 ,  A61K31/4415 ,  A61K31/4439 ,  C12Q1/686 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/6893 ,  G01N2333/988

摘要： The present invention provides a method for diagnosing schizophrenia, and a schizophrenia diagnostic reagent or device for use in the method. The present invention further provides a therapeutic or ameliorating agent for schizophrenia, which is effective for the treatment or amelioration of schizophrenia. The therapeutic or ameliorating agent for schizophrenia contains a carbonyl scavenger or a carbonyl-modified protein formation inhibitor as an active ingredient. The method for diagnosing schizophrenia according to the present invention includes measuring at least one parameter in a subject, the parameter being selected from the group consisting of: (1) a genetic abnormality of glyoxalase I gene; (2) the expression level or activity of glyoxalase I in a biological sample; (3) the amount of a carbonyl compound or a carbonyl-modified protein that is a protein modified with the carbonyl compound; and (4) the amount of pyridoxal in a biological sample.

公开(公告)号：EP1712125A4

公开(公告)日：2009-06-10

申请号：EP04820285

申请日：2004-12-09

申请人： JAPAN SCIENCE & TECH AGENCY ,  RENASCIENCE CO LTD

发明人： MIYATA TOSHIO ,  KUROKAWA KIYOSHI ,  YAMAMOTO HIROSHI ,  OKAMOTO HIROSHI

IPC分类号： A01K67/027 ,  C07K14/47 ,  C12N9/02 ,  C12N15/09 ,  C12N15/85 ,  G01N33/50

CPC分类号： C07K14/47 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/03 ,  C12N9/0075 ,  C12N15/8509 ,  G01N33/5088 ,  G01N2800/042 ,  G01N2800/347

摘要： A triple Tg (megsin/RAGE/iNOS-Tg) is constructed by crossing a megsin-Tg with an RAGE/iNOS-Tg. It is found out that this megsin/RAGE/iNOS-Tg suffers from the onset of remarkable diabetic kidney lesion at an early stage which has never been observed so far and shows various uniform lesion images such as glomerular enlargement. It is also found out that the animal showing these symptoms is useful as a model animal of diabetic nephropathy. That is to say, the disease model animal as described above overexpresses megsin gene, receptor for advanced glycation end product gene and inducible nitric oxide synthase gene and, therefore, suffers from renal dysfunction associated with glomerular disorders at an early stage.

公开(公告)号：EP2415755A4

公开(公告)日：2012-09-19

申请号：EP10758123

申请日：2010-03-31

申请人： RENASCIENCE CO LTD

发明人： MIYATA TOSHIO ,  MURANO KENJI ,  YAMAOKA NAGAHISA ,  MAEDA AKIHISA

IPC分类号： C07C233/81 ,  A61K31/196 ,  A61K31/341 ,  A61K31/381 ,  A61K31/4025 ,  A61K31/404 ,  A61K31/4418 ,  A61K31/4525 ,  A61P1/16 ,  A61P7/02 ,  A61P9/00 ,  A61P9/10 ,  A61P9/14 ,  A61P11/00 ,  A61P13/12 ,  A61P25/00 ,  A61P25/28 ,  A61P27/02 ,  A61P35/00 ,  A61P35/04

CPC分类号： C07D409/12 ,  C07C233/81 ,  C07D213/56 ,  C07D215/14 ,  C07D217/16 ,  C07D295/192 ,  C07D307/42 ,  C07D307/54 ,  C07D307/66 ,  C07D333/24 ,  C07D333/36 ,  C07D405/04 ,  C07D405/10 ,  C07D405/12

公开(公告)号：EP2990057A4

公开(公告)日：2016-12-28

申请号：EP14785000

申请日：2014-04-15

申请人： RENASCIENCE CO LTD

发明人： ANDO KIYOSHI ,  YAHATA TAKASHI ,  MIYATA TOSHIO

IPC分类号： A61K45/06 ,  A61K31/192 ,  A61K31/196 ,  A61K31/341 ,  A61K31/381 ,  A61K31/40 ,  A61K31/402 ,  A61K31/4025 ,  A61K31/404 ,  A61K31/4418 ,  A61K31/445 ,  A61K31/4525 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/495 ,  A61K31/506 ,  A61K45/00 ,  A61P7/00 ,  A61P35/00 ,  A61P43/00

CPC分类号： A61K31/341 ,  A61K31/192 ,  A61K31/196 ,  A61K31/381 ,  A61K31/40 ,  A61K31/402 ,  A61K31/4025 ,  A61K31/404 ,  A61K31/4418 ,  A61K31/445 ,  A61K31/4525 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/495 ,  A61K31/506 ,  A61K45/06

摘要： Provided is a novel use of a plasminogen activator inhibitor-1 inhibitor (PAI-1 inhibitor) that is used as an active ingredient of an agent for controlling a tumor stem cell, an agent for enhancing the antitumor effect of an antitumor agent, an agent for tumor chemotherapy, a stem-cell protecting drug, or a hematopoietic disorder improving agent.

公开(公告)号：EP2272822A4

公开(公告)日：2012-01-18

申请号：EP09729173

申请日：2009-03-31

申请人： RENASCIENCE CO LTD

发明人： MIYATA TOSHIO ,  YAMAOKA NAGAHISA ,  KODAMA HIDEHIKO ,  MURANO KENJI

IPC分类号： C07C235/74 ,  A61K31/167 ,  A61K31/196 ,  A61K31/245 ,  A61K31/34 ,  A61K31/36 ,  A61K31/385 ,  A61K31/40 ,  A61K31/415 ,  A61K31/42 ,  A61K31/421 ,  A61K31/4409 ,  A61K31/47 ,  A61P3/10 ,  A61P7/02

CPC分类号： C07C235/16 ,  C07C233/56 ,  C07C233/88 ,  C07C235/68 ,  C07C317/44 ,  C07C323/60 ,  C07C2601/14 ,  C07C2601/20 ,  C07D207/325 ,  C07D213/40 ,  C07D213/74 ,  C07D215/12 ,  C07D231/12 ,  C07D261/08 ,  C07D263/32 ,  C07D307/38 ,  C07D307/79 ,  C07D317/50 ,  C07D333/06