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公开(公告)号：EP3953384A1
公开(公告)日：2022-02-16
申请号：EP20722421.3
申请日：2020-04-08
申请人： SANOFI , The United States of America, represented by the Secretary, Department of Health and Human Services
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公开(公告)号：EP3906939A1
公开(公告)日：2021-11-10
申请号：EP21161239.5
申请日：2014-10-10
申请人： The United States of America, represented by the Secretary, Department of Health and Human Services
发明人： KANEKIYO, Masaru , NABEL, Gary J. , COHEN, Jeffrey , BU, Wei
IPC分类号： A61K39/12
摘要： Novel vaccines are provided that elicit neutralizing antibodies to Epstein-Barr virus (EBV). Some vaccines comprise nanoparticles that display envelope proteins from EBV on their surface. The nanoparticles comprise fusion proteins comprising a monomeric subunit of a self-assembly protein, such as ferritin, joined to at least a portion of an EBV envelope protein. The fusion proteins self-assemble to form the envelope protein-displaying nanoparticles. Such vaccines can be used to vaccinate an individual against infection by different types of Epstein-Barr viruses as well as Epstein-Barr viruses that are antigenically divergent from the virus from which the EBV envelope protein was obtained. Also provided are fusion proteins and nucleic acid molecules encoding such proteins.
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公开(公告)号：EP4257193A2
公开(公告)日：2023-10-11
申请号：EP23179697.0
申请日：2017-04-13
申请人： Sanofi
发明人： YANG, Zhi-Yong , LANGE, Christian , CORVEY, Carsten , NABEL, Gary J. , WU, Lan , SEUNG, Edward , WEI, Ronnie , BENINGA, Jochen , RAO, Ercole , LEUSCHNER, Wulf Dirk , BEIL, Christian
IPC分类号： A61P29/00
摘要： The disclosure provides trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. The disclosure also provides methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins.
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公开(公告)号：EP3773704A1
公开(公告)日：2021-02-17
申请号：EP19718031.8
申请日：2019-04-02
申请人： SANOFI
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公开(公告)号：EP3773703A1
公开(公告)日：2021-02-17
申请号：EP19717704.1
申请日：2019-04-02
申请人： SANOFI
IPC分类号： A61K39/12 , A61P31/16 , C07K14/205
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公开(公告)号：EP3773697A1
公开(公告)日：2021-02-17
申请号：EP19721893.6
申请日：2019-04-02
申请人： SANOFI
发明人： NABEL, Gary J. , WEI, Chih-Jen , KAMP, Heather , WEI, Ronnie , SWANSON, Kurt
IPC分类号： A61K39/02 , A61K39/145 , A61K39/12 , A61P31/04 , A61P31/20 , A61P31/14 , A61P31/16 , C07K14/205
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公开(公告)号：EP3953388A1
公开(公告)日：2022-02-16
申请号：EP20722422.1
申请日：2020-04-08
申请人： SANOFI
发明人： BIRKENFELD, Joerg , NABEL, Gary J. , QIU, Huawei , REGULA, Joerg , SEUNG, Edward , WEI, Ronnie , WU, Lan , XING, Zhen , XU, Ling , PRADES, Catherine , DABDOUBI, Tarik , CAMERON, Béatrice , LEMOINE, Cendrine , YANG, Zhi-Yong
IPC分类号： C07K16/28 , C12N5/0783
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公开(公告)号：EP3773708A2
公开(公告)日：2021-02-17
申请号：EP19729869.8
申请日：2019-04-02
申请人： SANOFI
发明人： NABEL, Gary J. , WEI, Chih-Jen , NGUYEN, Laura , SWANSON, Kurt , CHOU, Te-Hui , KOESTER, Stefan
IPC分类号： A61K39/12 , C07K14/205 , A61P31/20
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公开(公告)号：EP3773698A1
公开(公告)日：2021-02-17
申请号：EP19721896.9
申请日：2019-04-02
申请人： SANOFI
发明人： NABEL, Gary J. , WEI, Chih-Jen , SWANSON, Kurt
IPC分类号： A61K39/02 , A61K39/145 , A61K39/12 , A61P31/04 , A61P31/20 , A61P31/14 , A61P31/16 , C07K14/205
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公开(公告)号：EP3946446A1
公开(公告)日：2022-02-09
申请号：EP20722065.8
申请日：2020-04-01
申请人： Sanofi
发明人： SWANSON, Kurt , WEI, Chih-Jen , NABEL, Gary J.
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