公开(公告)号：EP4048703A1

公开(公告)日：2022-08-31

申请号：EP20790347.7

申请日：2020-10-21

Applicant: VIB VZW ,  Vrije Universiteit Brussel ,  United Kingdom Research and Innovation

Inventor： STEYAERT, Jan ,  UCHANSKI, Tomasz ,  MASIULIS, Simonas ,  ARICESCU, Alexandru, Radu

IPC: C07K16/46 ,  C07K14/205 ,  C07K14/775 ,  C07K16/18 ,  C07K16/44 ,  G01N33/68

公开(公告)号：EP3898664A1

公开(公告)日：2021-10-27

申请号：EP19832112.7

申请日：2019-12-20

Applicant: VIB VZW ,  Vrije Universiteit Brussel ,  Luxembourg Institute of Health

Inventor： STEYAERT, Jan ,  PARDON, Els ,  WOHLKÖNIG, Alexandre ,  KALICHUK, Valentina ,  VRANKEN, Wim ,  UCHANSKI, Tomasz ,  CHEVIGNÉ, Andy ,  SZPAKOWSKA, Martyna

IPC: C07K14/52 ,  C07K19/00 ,  C07K14/205 ,  C07K14/715

公开(公告)号：EP2853600B1

公开(公告)日：2018-09-19

申请号：EP14199949.0

申请日：2006-05-10

Applicant: ETH Zürich

Inventor： Aebi, Markus ,  Kowarik, Michael ,  Ahuja, Umesh

IPC: C12P21/00 ,  C12N9/10 ,  C12N15/70 ,  C07K14/205 ,  C07K14/25

CPC classification number: C12P21/005 ,  C07K14/205 ,  C07K14/25 ,  C07K2319/034 ,  C12N9/1051 ,  C12N15/70 ,  C12Y204/01

Abstract: The present invention relates to recombinant N-glycosylated proteins, comprising one or more introduced N-glycosylated optimized amino acid sequence(s), pharmaceutical compositions comprising said proteins as well as corresponding vectors and host cells. In addition, the present invention provides methods for producing said proteins.

公开(公告)号：EP2137305B1

公开(公告)日：2014-11-05

申请号：EP08748154.5

申请日：2008-04-18

Applicant: NATIONAL RESEARCH COUNCIL OF CANADA

Inventor： BERNATCHEZ, Stephane ,  GILBERT, Michel ,  WAKARCHUK, Warren

IPC: C12N9/10 ,  C07K14/205 ,  C07K14/145 ,  C07K19/00 ,  C12P19/00 ,  C12P19/44 ,  C12P21/00

CPC classification number: C12P21/005 ,  C12N9/1051 ,  C12P19/44

公开(公告)号：EP1698698B1

公开(公告)日：2014-02-12

申请号：EP04819936.8

申请日：2004-12-03

Applicant: FUSO PHARMACEUTICAL INDUSTRIES, LTD.

Inventor： YAMASAKI, Shinji ,  ASAKURA, Masahiro

IPC: C12Q1/68 ,  C12N15/31 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/00 ,  C07K14/205 ,  C07K16/12 ,  C12P21/02 ,  G01N33/50 ,  G01N33/569

CPC classification number: C07K14/205 ,  C12Q1/686 ,  C12Q1/689 ,  C12Q2600/16 ,  Y02A50/451

Abstract: The present inventors succeeded in cloning the CDT genes of C. coli and C. fetus, which were previously unknown, and in determining their sequences. In addition, the inventors also developed specific primers and primers common to the two species by comparing the CDTs of C. jejuni and C. fetus. Furthermore, the inventors demonstrated that these primers were applicable to multiplex PCR that simultaneously allows for the rapid and convenient determination of the presence of Campylobacter CDT and identification of species, and that they can also be used in PCR-RFLP-based typing.

公开(公告)号：EP1694697B1

公开(公告)日：2010-12-29

申请号：EP04797464.7

申请日：2004-11-19

Applicant: Ace Biosciences A/S

Inventor： SCHROTZ-KING, Petra ,  SKAARUP, Crawford, Janne ,  NYBORG, Nielsen, Pia ,  PROKHOROVA, Tatyana, A.

IPC: C07K14/205 ,  C12N15/11 ,  G01N33/569 ,  C07K16/12 ,  A61K39/02

CPC classification number: C07K14/205 ,  A61K39/105 ,  Y02A50/47

Abstract: The present invention relates to surface-located polypeptides of Campylobacter jejuni and their use in vaccination against Campylobacter. The invention furthermore relates to the use in vaccination of polynucleotides, expression vectors, recombinant viruses or recombinant cells expressing these surface-located polypeptides. Moreover, the invention relates to the use of antibodies against the surface-located polypeptides for anti-Campylobacter therapy. Finally, methods for detection of Campylobacter and for identifying anti-Campylobacter agents through the surface-located polypeptides is disclosed.

公开(公告)号：EP0931093B1

公开(公告)日：2008-04-16

申请号：EP97940148.6

申请日：1997-09-01

Applicant: Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

Inventor： MEYER, Thomas, F. ,  HAAS, Rainer ,  YAN, Zhengxin ,  GOMEZ-DUARTE, Oscar ,  LUCAS, Bernadette

IPC: C07K14/205 ,  C07K16/12 ,  C12N15/10 ,  C12N15/31 ,  C12N15/74 ,  A61K39/112

CPC classification number: C12N9/78 ,  A61K39/00 ,  C07K14/205 ,  C12N15/74

Abstract: The present invention relates to novel recombinant live vaccines, which provide protective immunity against an infection by Helicobacter pylori and a method of screening H. pylori antigens for optimized vaccines.

公开(公告)号：EP1586646A3

公开(公告)日：2007-08-01

申请号：EP05104073.1

申请日：2001-12-14

Applicant: Intervet International BV

Inventor： Jacobs, Antonius Arnoldus Christiaan ,  Vermeij, Paul

IPC: C12N15/31 ,  C12N1/21 ,  C12Q1/68 ,  C07K14/195 ,  C07K14/205 ,  A61K39/02 ,  A61K39/40 ,  G01N33/569

CPC classification number: C07K14/205 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K14/195

Abstract: The present invention relates i.a. to nucleic acid sequences encoding novel Lawsonia intracellularis proteins. It furthermore relates to DNA fragments, recombinant DNA molecules and live recombinant carriers comprising these sequences. Also it relates to host cells comprising such nucleic acid sequences, DNA fragments, recombinant DNA molecules and live recombinant carriers. Moreover, the invention relates to proteins encoded by these nucleotide sequences. The invention also relates to vaccines for combating Lawsonia intracellularis infections and methods for the preparation thereof. Finally the invention relates to diagnostic tests for the detection of Lawsonia intracellularis DNA, the detection of Lawsonia intracellularis antigens and of antibodies against Lawsonia intracellularis.

公开(公告)号：EP1807110A2

公开(公告)日：2007-07-18

申请号：EP05796628.5

申请日：2005-10-25

Applicant: The Secretary of State for Environment, Food & Rural Affairs

Inventor： NEWELL, Diane Veterinary Laboratories Agency ,  CAWTHRAW,Shaun Veterinary Laboratories Agency

IPC: A61K39/106 ,  A61K48/00 ,  C07K14/205

CPC classification number: C07K14/205 ,  A61K48/00

Abstract: Nucleic acids encoding Campylobacter proteins, in particular antigenic proteins such as a flagellin, or encoding a variant thereof, or a fragment of either of these, are capable of protecting poultry such as chickens, against colonisation by Campylobacter, and so may be used in veterinary therapy or prophylaxis. This has an impact on human health.

公开(公告)号：EP0909323B1

公开(公告)日：2007-02-28

申请号：EP97901240.8

申请日：1997-01-03

Applicant: Novartis Vaccines and Diagnostics, Inc.

Inventor： BYRNE, William ,  KELLEHER, Dermot ,  WINDLE, Henry ,  McMANUS, Ross

IPC: C12N15/31 ,  C07K14/205 ,  C12N1/21 ,  C12N15/70 ,  C12Q1/68 ,  A61K47/42 ,  A61K33/00 ,  A61K38/16 ,  A61K39/106 ,  A61K39/40 ,  C07K16/12

CPC classification number: C07K14/205 ,  A61K39/00

Abstract: A nucleic acid sequence encoding all or part of an 18-19 kDa Helicobacter pylori protein is described to which immunoreactivity is detected in H. pylori negative individuals. A process for the production of a recombinant form of this protein and its use, particularly as a vaccine to provide immunological protection against H. pylori infection are also described.

Abstract translation: 描述了编码全部或部分18-19kDa幽门螺杆菌蛋白质的核酸序列，其在幽门螺杆菌阴性个体中检测到免疫反应性。 还描述了生产该蛋白的重组形式及其用途的方法，特别是作为提供针对幽门螺杆菌感染的免疫保护的疫苗。