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公开(公告)号：EP4257193A2
公开(公告)日：2023-10-11
申请号：EP23179697.0
申请日：2017-04-13
申请人： Sanofi
发明人： YANG, Zhi-Yong , LANGE, Christian , CORVEY, Carsten , NABEL, Gary J. , WU, Lan , SEUNG, Edward , WEI, Ronnie , BENINGA, Jochen , RAO, Ercole , LEUSCHNER, Wulf Dirk , BEIL, Christian
IPC分类号： A61P29/00
摘要： The disclosure provides trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. The disclosure also provides methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins.
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公开(公告)号：EP3773704A1
公开(公告)日：2021-02-17
申请号：EP19718031.8
申请日：2019-04-02
申请人： SANOFI
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公开(公告)号：EP3953384A1
公开(公告)日：2022-02-16
申请号：EP20722421.3
申请日：2020-04-08
申请人： SANOFI , The United States of America, represented by the Secretary, Department of Health and Human Services
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公开(公告)号：EP3773703A1
公开(公告)日：2021-02-17
申请号：EP19717704.1
申请日：2019-04-02
申请人： SANOFI
IPC分类号： A61K39/12 , A61P31/16 , C07K14/205
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公开(公告)号：EP3773697A1
公开(公告)日：2021-02-17
申请号：EP19721893.6
申请日：2019-04-02
申请人： SANOFI
发明人： NABEL, Gary J. , WEI, Chih-Jen , KAMP, Heather , WEI, Ronnie , SWANSON, Kurt
IPC分类号： A61K39/02 , A61K39/145 , A61K39/12 , A61P31/04 , A61P31/20 , A61P31/14 , A61P31/16 , C07K14/205
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公开(公告)号：EP3953388A1
公开(公告)日：2022-02-16
申请号：EP20722422.1
申请日：2020-04-08
申请人： SANOFI
发明人： BIRKENFELD, Joerg , NABEL, Gary J. , QIU, Huawei , REGULA, Joerg , SEUNG, Edward , WEI, Ronnie , WU, Lan , XING, Zhen , XU, Ling , PRADES, Catherine , DABDOUBI, Tarik , CAMERON, Béatrice , LEMOINE, Cendrine , YANG, Zhi-Yong
IPC分类号： C07K16/28 , C12N5/0783
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公开(公告)号：EP3773708A2
公开(公告)日：2021-02-17
申请号：EP19729869.8
申请日：2019-04-02
申请人： SANOFI
发明人： NABEL, Gary J. , WEI, Chih-Jen , NGUYEN, Laura , SWANSON, Kurt , CHOU, Te-Hui , KOESTER, Stefan
IPC分类号： A61K39/12 , C07K14/205 , A61P31/20
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公开(公告)号：EP3773698A1
公开(公告)日：2021-02-17
申请号：EP19721896.9
申请日：2019-04-02
申请人： SANOFI
发明人： NABEL, Gary J. , WEI, Chih-Jen , SWANSON, Kurt
IPC分类号： A61K39/02 , A61K39/145 , A61K39/12 , A61P31/04 , A61P31/20 , A61P31/14 , A61P31/16 , C07K14/205
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公开(公告)号：EP3946446A1
公开(公告)日：2022-02-09
申请号：EP20722065.8
申请日：2020-04-01
申请人： Sanofi
发明人： SWANSON, Kurt , WEI, Chih-Jen , NABEL, Gary J.
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10.发明公开
公开(公告)号：EP3819310A1
公开(公告)日：2021-05-12
申请号：EP20197556.2
申请日：2016-10-24
发明人： YANG, Zhi-Yong , NABEL, Gary J. , XU, Ling , WEI, Ronnie , QIU, Huawei , BENINGA, Jochen , KRUIP, Jochen , RAO, Ercole , LEUSCHNER, Wulf Dirk , BEIL, Christian , LANGE, Christian , CONNORS, Mark , MASCOLA, John R. , KOUP, Richard A. , HUANG, Jinghe , DORIA-ROSE, Nicole A. , ZHOU, Tongqing , KWONG, Peter D. , KWON, Young Do. , PEGU, Amarendra , ASOKAN, Mangaiarkarasi
摘要： Provided herein are compositions comprising trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more HIV target proteins or one or more T-cell receptors, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. Also provided herein are methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins for the treatment and/or prevention of HIV/AIDS.
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