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    LEUKOTRIEN-B 4?-DERIVATE, INSBESONDERE OXIMO-LTB 4?-ANTAGONISTEN
    2.
    发明公开
    LEUKOTRIEN-B 4?-DERIVATE, INSBESONDERE OXIMO-LTB 4?-ANTAGONISTEN 失效
    白藜芦醇-4？ATE ATE，E TEN TEN TEN TEN TEN TEN TEN TEN TEN TEN TEN

    公开(公告)号：EP0983235A2

    公开(公告)日：2000-03-08

    申请号：EP98930743.4

    申请日：1998-05-22

    Applicant: SCHERING AKTIENGESELLSCHAFT

    Inventor： BUCHMANN, Bernd ,  FRÖHLICH, Wolfgang ,  GIESEN, Claudia ,  HENNEKES, Hartwig ,  JAROCH, Stefan ,  SKUBALLA, Werner

    IPC: C07C405/00

    CPC classification number: C07D277/56 ,  C07C403/08 ,  C07C2601/04 ,  C07C2601/14 ,  C07D257/06 ,  C07D277/24

    Abstract: The invention relates to leukotriene B4 derivatives of general formula (I) in which R1 stands for H, CF3, CH2OH; R2 stands for an organic acid radical; R3 stands for H, C1-C14-alkyl, C3-C10-cycloalkyl, or a 5-6-link aromatic heterocyclic ring with at least one heteroatom; R4 is hydrogen, C1-C10-alkyl, C3-C10-cycloalkyl; A is a trans-, trans-CH=CH-CH=CH, a -CH2CH2-CH=CH- or a tetramethylene group; B is a C1-C10 linear or branched-chain aklylene group or the group (a) or (b); D is a direct bonding, oxygen, sulphur, -C C-, -CH=CR7, or a direct bonding with B; R5 and R6 are identical or different and are H or C1-C4-alkyl, or R6 stands for H and R5 stands for C1-C15-alkanoyl or R8 SO2-; R7 is H, C1-C5-alkyl, chlorine, bromine; R8 is the same as R3; m is 1-3; o is 0-5; p is 0-5; x is a direct bonding, oxygen, sulphur, an aromatic or heterocyclic compound; y is a C1-C8-alkyl, C3-C10-cycloalkyl; n is 2-5. When R4 is hydrogen, the invention also relates to their salts with physiologically compatible bases and their cyclodextrin clathrates. The leukotriene derivatives are used as dermatological products.

    Abstract translation: PCT No.PCT / EP98 / 03139 371日期2000年3月27日 102（e）日期2000年3月27日PCT提交1998年5月22日PCT公布。 WO98 / 52915 PCT公开号 日本公开日1998年11月26日通式（I）的二氢三烯-BB衍生物，其中R1表示H，CF3，CH2OH和R2表示H或有机酸基; R3表示H，C 1 -C 14烷基，C 3 -C 10环烷基或具有至少1个杂原子的5至6元芳族杂环; R4表示氢，C1-C10烷基，C3-C10环烷基; A表示反式，反式-CH = CH-CH = CH，-CH 2 CH 2 -CH = CH-或四亚甲基; B表示C1-C10-直链或支链亚烷基或基团（a）或（b）; D可以表示直接键，氧，硫，-C 3位C，-CH = CR 7，或与B一起也可以是直接键; R5和R6相同或不同，代表H或C1-C4烷基，或R6表示H，R5代表C1-C15烷酰基或R8代表SO2; R7表示H，C1-C5烷基，氯，溴; R8与R3相同，m表示1-3，o表示0-5，p表示0-5，X表示直接键，氧，硫，芳香族化合物或杂芳族化合物，Y表示C1〜C8烷基 ，C 3 -C 10环烷基，n为2-5，并且如果R 4表示氢，则其与生理上相容的碱和它们的环糊精包合物的盐。 白三烯衍生物用作皮肤病学产品。

    LEUKOTRIEN-B 4?-DERIVATE, INSBESONDERE 7-METHYLCYCLOHEXYL-LTB 4?-ANTAGONISTEN
    4.
    发明公开
    LEUKOTRIEN-B 4?-DERIVATE, INSBESONDERE 7-METHYLCYCLOHEXYL-LTB 4?-ANTAGONISTEN 失效
    白三烯B 4？衍生物尤其是7-甲基环己基LTB4？拮抗剂

    公开(公告)号：EP0983234A1

    公开(公告)日：2000-03-08

    申请号：EP98928323.9

    申请日：1998-05-22

    Applicant: Schering Aktiengesellschaft

    Inventor： BUCHMANN, Bernd ,  FRÖHLICH, Wolfgang ,  GIESEN, Claudia ,  HENNEKES, Hartwig ,  JAROCH, Stefan ,  SKUBALLA, Werner

    IPC: C07C405/00

    CPC classification number: C07C405/0066 ,  C07C405/00

    Abstract: The invention relates to leukotriene B4 derivatives of general formula (I) in which R1 stands for CH2OH, CH3, CF3, COOR4, CONR5R6; R2 stands for H or an organic acid radical with 1-15 C atoms; R3 stands for H; R4 is hydrogen, C1-C10-alkyl, C3-C10-cycloalkyl, a C6-C10-aryl radical optionally substituted by 1-3 halogen, phenyl, C1-C4-alkyl, C1-C4-alkoxy, fluoromethyl, chloromethyl, trifluoromethyl, carboxyl or hydroxy, or CH2-CO-(C6-C10) aryl, or a 5-6 link ring with at least 1 heteroatom; A is a trans-, trans-CH=CH-CH=CH, a -CH2CH2-CH=CH- or a tetramethylene group; B is a C1-C10 linear or branched-chain aklylene group or the group (a) or (b); D is a direct bonding, oxygen, sulphur, -C C-, -CH=CR7, or a direct bonding with B. The invention also relates to salts thereof, having physiologically compatible bases and their cyclodextrin clathrates. The inventive substances can be used as pharmaceutical preparations.

    NEUE 9H-PYRIDO 3,4-b]INDOL-DERIVATE
    6.
    发明公开
    NEUE 9H-PYRIDO 3,4-b]INDOL-DERIVATE 失效
    NEW -9H-吡啶并3,4--B的吲哚衍生物

    公开(公告)号：EP0805810A1

    公开(公告)日：1997-11-12

    申请号：EP96901309.0

    申请日：1996-01-19

    Applicant: SCHERING AKTIENGESELLSCHAFT

    Inventor： SKUBALLA, Werner ,  BUCHMANN, Bernd ,  REHWINKEL, Hartmut ,  SCHNEIDER, Frank ,  FRÖHLICH, Wolfgang ,  GIESEN, Claudia ,  HENNEKES, Hartwig

    IPC: A61K31 ,  C07D471 ,  C07D491

    CPC classification number: C07D471/04

    Abstract: Novel 9H-pyrido[3,4-b]indol derivatives of general formula (I), in which U, V and W are a carbon-carbon bond or a C1-C6 alkylene group, R1 is a hydrogen atom, a hydroxy group or a carboxyl group and R2 is a hydrogen atom, a hydroxy group, a C1-C4 alkoxy group, a C1-C6 alkanoyloxy group or a C1-C4-φ carboxyl alkoxy group, or R1 and R2 together are an oxycarbonyl group and in which X is a carbon-carbon bond or oxygen, Y is a carbon-carbon bond, the group -CONR'- with R' as a hydrogen atom or a C1-C7 alkyl group possibly substituted by a carboxyl group, or the grouping (a) where m and n are figures of a total of 3,4 or 5 and Z is a methylidine or an aza group, and R3 and R4 are a naphthyl group possibly substituted by halogen atoms, trifluoromethyl groups, a C1-C7 alkyl C1-C4 alkoxy group or carboxyl groups and, in the case of the carboxylic acids of general formula (I), their esters of physiologically acceptable alcohols, their amides of physiologically acceptable amines and their salts of physiologically acceptable bases with anti-leucotriene B4 action are described.

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