公开(公告)号：EP0736030B1

公开(公告)日：2001-08-29

申请号：EP95906620.0

申请日：1994-12-20

申请人： SCHERING CORPORATION

发明人： SAKSENA, Anil, K. ,  GIRIJAVALLABHAN, Viyyoor, M. ,  LOVEY, Raymond, G. ,  PIKE, Russell, E. ,  WANG, Haiyan ,  LIU, Yi-Tsung ,  GANGULY, Ashit, K. ,  BENNETT, Frank

IPC分类号： C07D521/00 ,  C07F9/6558 ,  A61K31/495 ,  A61K31/66

CPC分类号： C07D249/08 ,  C07D231/12 ,  C07D233/56 ,  C07F9/65586

摘要： A compound represented by formula (I) wherein X is independently both F or both Cl or one X is independently F and the other is independently Cl; R1 is a straight or branched chain (C3 to C8) alkyl group substituted by one or two hydroxy moieties, an ether or ester (e.g., a polyestherester or phosphate ester) thereof a pharmaceutically acceptable salt thereof and pharmaceutical compositions thereof useful for treating and/or preventing fungal infections are disclosed.

公开(公告)号：EP1121369A1

公开(公告)日：2001-08-08

申请号：EP99970662.5

申请日：1999-10-14

申请人： SCHERING CORPORATION

发明人： GANGULY, Ashit, K. ,  MCCORMICK, Jinping ,  LOVEY, Raymond, G. ,  BENNETT, Frank ,  SAKSENA, Anil, K. ,  GIRIJAVALLABHAN, Viyyoor, M.

IPC分类号： C07H19/056 ,  A61K31/70

CPC分类号： C07H19/056

摘要： A method for treating a patient having chronic hepatitis C infection to eradicate detectable HCV-RNA involving a combination therapy using a therapeutically effective amount of ribavirin derivative of formula (I) and a therapeutically effective amount of interferon-alpha for a time period of from 20 up to 80 weeks.

摘要翻译： 一种治疗患有慢性丙型肝炎感染的患者以根除可检测的HCV-RNA的方法，涉及组合疗法，使用治疗有效量的式（I）的利巴韦林衍生物和治疗有效量的干扰素-α，时间为20 长达80周。

公开(公告)号：EP1282632A1

公开(公告)日：2003-02-12

申请号：EP01928662.4

申请日：2001-04-18

申请人： SCHERING CORPORATION

发明人： GANGULY, Ashit, K. ,  MCCORMICK, Jinping ,  LOVEY, Raymond, G. ,  BENNETT, Frank ,  SAKSENA, Anil, K. ,  GIRIJAVALLABHAN, Viyyoor, M.

IPC分类号： C07H19/056 ,  A61K31/7056 ,  A61P31/12

CPC分类号： C07H19/056 ,  Y10S514/894

摘要： Ribavirin derivatives represented by the formula (II), pharmaceutical compositions containing them as well as the use of the ribavirin derivatives represented by the formula (II) for the preparation of a medicament for the treatment of susceptible viral infections, for example, chronic hepatitis C infections administrating, the ribavirin derivatives being represented by formula (II) are disclosed.

公开(公告)号：EP0590026B1

公开(公告)日：1999-08-04

申请号：EP92913416.1

申请日：1992-06-17

申请人： SCHERING CORPORATION

发明人： GIRIJAVALLABHAN, Viyyoor, M. ,  GANGULY, Ashit, K. ,  VERSACE, Richard, W. ,  SAKSENA, Anil, K. ,  PINTO, Patrick, A.

IPC分类号： C07C43/225 ,  A61K31/09 ,  C07D307/28 ,  C07D213/30 ,  C07C69/92 ,  A61K31/44 ,  A61K31/235 ,  A61K31/34

CPC分类号： C07D213/30 ,  C07C43/225 ,  C07C43/23 ,  C07C69/92 ,  C07D263/14 ,  C07D307/12 ,  C07D307/28 ,  C07D307/42 ,  C07D333/16

公开(公告)号：EP0165272A1

公开(公告)日：1985-12-27

申请号：EP85900083.0

申请日：1984-11-22

申请人： SCHERING CORPORATION

发明人： GIRIJAVALLABHAN, Viyyor, M. ,  GANGULY, Ashit, K. ,  VERSACE, Richard, W.

IPC分类号： C07D205 ,  C07D233 ,  C07D499 ,  C07F7

CPC分类号： C07D233/64 ,  C07D205/09 ,  C07D499/88 ,  C07F7/186

摘要： Pénèmes de formule générale (I) où n vaut 1, 2 ou 3; m vaut 1, 2 ou 3; Z représente -COH, -SO3H ou (III); R, R1, R2 et R3 représentent de manière indépendante un hydrogène, un alcoyle inférieur, un hydroxyalcoyle inférieur, un aminoalcoyle inférieur, un carboxyalcoyle inférieur, un thioalcoyle inférieur, un alcoyle inférieur d'alcoxy inférieur, -NH-CO- d'alcoyle inférieur, un aminocarbonylalcoyle inférieur, un cyanoalcoyle inférieur, un fluoroalcoyle inférieur, un carbamoyloxyalcoyle inférieur ou un sulfamoyloxy, à condition que, lorsque m vaut 2 ou 3, R, R1, R2 et R3 puissent indépendamment de manière supplémentaire représenter un hydroxy, un amino, un cyano, un fluoro, un carbomoyloxy, un carbamyle ou -SO3H; X1 représente O, S ou NH, et chaque X représente N ou CH à condition qu'au moins un X représente N si X1 ne représente pas NH, et qu'au moins un X représente CH, mais qu'au moins deux groupes X représentent CH si X1 représente O ou S.

公开(公告)号：EP1481000B1

公开(公告)日：2010-06-02

申请号：EP03731956.3

申请日：2003-01-16

申请人： Schering Corporation ,  DENDREON CORPORATION

发明人： SAKSENA, Anil, K. ,  GIRIJAVALLABHN, Viyyoor, M. ,  LOVEY, Raymond, G. ,  JAO, Edwin ,  BENNETT, Frank ,  MC CORMICK, Jinping, L. ,  WANG, Haiyan ,  PIKE, Russell, E. ,  BOGEN, Stephane, L. ,  CHAN, Tin-Yau ,  LIU, Yi-Tsung ,  ZHU, Zhaoning ,  NJOROGE, George, F. ,  ARASAPPAN, Ashok ,  PAREKH, Tejal ,  GANGULY, Ashit, K. ,  CHEN, Kevin, X. ,  VENKATRAMAN, Srikanth ,  VACCARO, Henry, A. ,  PINTO, Patrick A. ,  SANTHANAM, Bama ,  KEMP, Scott Jeffrey ,  LEVY, Odile Esther ,  LIM-WILBY, Marguerita ,  TAMURA, Susan Y. ,  WU, Wanli ,  HENDRATA, Siska ,  HUANG, Yuhua ,  WONG, Jesse K. ,  NAIR, Latha G.

IPC分类号： C07K5/062 ,  C07K5/065 ,  A61K38/55

CPC分类号： C07K5/0804 ,  A61K38/00 ,  C07K5/0202 ,  C07K5/0812 ,  C07K5/0827 ,  C07K7/02

摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.

公开(公告)号：EP0773941B1

公开(公告)日：2003-05-14

申请号：EP96916574.5

申请日：1996-05-30

申请人： SCHERING CORPORATION

发明人： SAKSENA, Anil, K. ,  GIRIJAVALLABHAN, Viyyoor, M. ,  LOVEY, Raymond, G. ,  PIKE, Russell, E. ,  WANG, Haiyan ,  LIU, Yi-Tsung ,  GANGULY, Ashit, K. ,  BENNETT, Frank

IPC分类号： C07D405/14 ,  A61K31/41

CPC分类号： C07D249/08 ,  C07D231/12 ,  C07D233/56

摘要： A compound represented by formula (I), wherein X is independently both F or both Cl or one X is independently F and the other is independently Cl; R1 is a straight or branched chain (C4 to C5) alkyl group substituted by one or two amino acid ester grou ps convertible in vivo into a hydroxy group or a pharmaceutically acceptable salt thereof and pharmaceutical compositions thereof useful for treating and/or preventing fungal infections are disclosed.

公开(公告)号：EP0610377B1

公开(公告)日：2001-01-24

申请号：EP92923060.5

申请日：1992-10-28

申请人： SCHERING CORPORATION

发明人： SAKSENA, Anil, K. ,  GIRIJAVALLABHAN, Viyyoor, M. ,  GANGULY, Ashit, K. ,  LOVEY, Raymond, G.

IPC分类号： C07D405/06 ,  C07D249/12 ,  C07D295/08 ,  C07D207/09 ,  C07D405/14 ,  A61K31/41

CPC分类号： C07D295/096 ,  C07D207/09 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D249/12

摘要： An antifungal compound represented by formula (I), wherein X is independently both F or both Cl or one X is F and the other is Cl; Y = (a), (b), (c), (d), (e), (f) or (g); R' = (C1-C10)alkyl, (C2-C10)alkenyl, (C2-C10)alkynyl, (C3-C8)cycloalkyl or CH2R?2; R2 = (C¿1-C3)perhaloalkyl, CO2R3, *CH(OR4)CH2OR4 or CH¿2?N(R?5); R3¿ = lower alkyl or H; R4 = R3 or (CH¿2?)2OR?3; R5¿ = lower alkyl; Z = H or (C¿1?-C5)alkanoyl and the carbons with the asterisks (*) have the R or S absolute configuration; or a pharmaceutically acceptable salt thereof as well as pharmaceutical compositions containing them and a method of treating or preventing fungal infections in mammals using them are disclosed.

公开(公告)号：EP0618913B1

公开(公告)日：1996-08-14

申请号：EP93901329.8

申请日：1992-12-17

申请人： SCHERING CORPORATION

发明人： SHIH, Neng-Yang ,  ASLANIAN, Robert ,  LUPO, Andrew, Jr. ,  PIWINSKI, John, J. ,  GREEN, Michael, J. ,  GANGULY, Ashit, K.

IPC分类号： C07D401/06 ,  A61K31/415 ,  C07D403/06

CPC分类号： C07D403/04 ,  C07D403/06

摘要： Disclosed is a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof. Also disclosed are pharmaceutical compositions comprising a pharmaceutically acceptable carrier and an effective amount of a compound of formula (I). Further disclosed is a method of treating allergy (for example asthma), inflammation, hypertension, raised intraocular pressure (such as glaucoma)--i.e., a method of lowering intraocular pressure, sleeping disorders, states of hyper and hypo motility and acidic secretion of the gastrointestinal tract, hypo and hyerpactivity of the central nervous system (for example, agitation and depression) and other CNS disorders (such as Alzheimers, schizophrenia, and migraine) comprising administering an effective amount of a compound of formula (I) to a patient in need of such treatment.

公开(公告)号：EP0489818A1

公开(公告)日：1992-06-17

申请号：EP90913304.0

申请日：1990-08-30

申请人： SCHERING CORPORATION

发明人： GIRIJAVALLABHAN, Viyyoor, M. ,  GANGULY, Ashit, K. ,  VERSACE, Richard, W.

IPC分类号： C07C33 ,  C07C69 ,  C07C315 ,  C07C317 ,  C07D249 ,  C07D319 ,  C07D407 ,  C07D521

CPC分类号： C07D231/12 ,  C07C33/46 ,  C07C69/78 ,  C07C315/02 ,  C07C317/16 ,  C07D233/56 ,  C07D249/08 ,  C07D319/06 ,  C07D407/12

摘要： Des intermédiaires dont la formule de constitution est (III) ou (Va), possédant un centre asymétrique indiqué par un astérisque (*) et étant sensiblement dépourvu de sa forme énantiomère opposée, dans laquelle Z représente O ou NOP1; P1 est (a), (b), (c), H, alkyle, benzyle, benzyle substitué, phényle substitué par alkoxy, alkyloxyalkyle, alkylthioalkyle, ou R'R''R''' silyle, R1 et R2 peuvent être les mêmes ou différents et chacun représente indépendamment H, alkyle, phényle, phényle substitué ou R1 et R2 ainsi que le carbone auquel ils sont liés représentent le groupe (d), Y est O, S(O)p ou (CRaRb); et des procédés servant à fabriquer des composés antifongiques énantiomères et chimiquement purs par synthèse chimique asymétrique dérivée de thréonine.