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公开(公告)号：EP1385870B1
公开(公告)日：2010-03-17
申请号：EP01954764.5
申请日：2001-07-19
发明人： SAKSENA, Anil, K. , GIRIJAVALLABHAN, Viyyoor, Moopil , LOVEY, Raymond, G. , JAO, Edwin, E. , BENNETT, Frank , MC CORMICK, Jinping, L. , WANG, Haiyan , PIKE, Russell, E. , BOGEN, Stephane, L. , CHAN, Tin-Yau , LIU, Yi-Tsung , ZHU, Zhaoning , NJOROGE, F., George , ARASAPPAN, Ashok , PAREKH, Tejal, N. , GANGULY, Ashit, K. , CHEN, Kevin, X. , VENKATRAMAN, Srikanth , VACCARO, Henry, A. , PINTO, Patrick A. , SANTHANAM, Bama , WU, Wanli , HENDRATA, Siska , HUANG, Yuhua , KEMP, Scott Jeffrey , LEVY, Odile Esther , LIM-WILBY, Marguerita , TAMURA, Susan Y.
IPC分类号： C07K1/00
CPC分类号： C07K5/0202 , A61K38/00 , C07K5/0812 , C07K5/0827 , C07K7/02
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
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2.发明公开
公开(公告)号：EP1481000A2
公开(公告)日：2004-12-01
申请号：EP03731956.3
申请日：2003-01-16
发明人： SAKSENA, Anil, K. , GIRIJAVALLABHN, Viyyoor, M. , LOVEY, Raymond, G. , JAO, Edwin , BENNETT, Frank , MC CORMICK, Jinping, L. , WANG, Haiyan , PIKE, Russell, E. , BOGEN, Stephane, L. , CHAN, Tin-Yau , LIU, Yi-Tsung , ZHU, Zhaoning , NJOROGE, George, F. , ARASAPPAN, Ashok , PAREKH, Tejal , GANGULY, Ashit, K. , CHEN, Kevin, X. , VENKATRAMAN, Srikanth , VACCARO, Henry, A. , PINTO, Patrick A. , SANTHANAM, Bama , KEMP, Scott Jeffrey , LEVY, Odile Esther , LIM-WILBY, Marguerita , TAMURA, Susan Y. , WU, Wanli , HENDRATA, Siska , HUANG, Yuhua , WONG, Jesse K. , NAIR, Latha G.
CPC分类号： C07K5/0804 , A61K38/00 , C07K5/0202 , C07K5/0812 , C07K5/0827 , C07K7/02
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
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3.发明授权
公开(公告)号：EP1481000B1
公开(公告)日：2010-06-02
申请号：EP03731956.3
申请日：2003-01-16
发明人： SAKSENA, Anil, K. , GIRIJAVALLABHN, Viyyoor, M. , LOVEY, Raymond, G. , JAO, Edwin , BENNETT, Frank , MC CORMICK, Jinping, L. , WANG, Haiyan , PIKE, Russell, E. , BOGEN, Stephane, L. , CHAN, Tin-Yau , LIU, Yi-Tsung , ZHU, Zhaoning , NJOROGE, George, F. , ARASAPPAN, Ashok , PAREKH, Tejal , GANGULY, Ashit, K. , CHEN, Kevin, X. , VENKATRAMAN, Srikanth , VACCARO, Henry, A. , PINTO, Patrick A. , SANTHANAM, Bama , KEMP, Scott Jeffrey , LEVY, Odile Esther , LIM-WILBY, Marguerita , TAMURA, Susan Y. , WU, Wanli , HENDRATA, Siska , HUANG, Yuhua , WONG, Jesse K. , NAIR, Latha G.
CPC分类号： C07K5/0804 , A61K38/00 , C07K5/0202 , C07K5/0812 , C07K5/0827 , C07K7/02
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
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公开(公告)号：EP1664092A1
公开(公告)日：2006-06-07
申请号：EP04784827.0
申请日：2004-09-23
申请人： SCHERING CORPORATION
发明人： VENKATRAMAN, Srikanth , NJOROGE, F., George , WU, Wanli , GIRIJAVALLABHAN, Viyyoor, M. , MCKITTRICK, Brian , SU, Jing , VELAZQUEZ, Francisco , PINTO, Patrick, A.
IPC分类号： C07K5/12 , C07D245/00 , A61K38/12
CPC分类号： C07D245/04 , A61K31/33 , A61K38/12 , A61K38/21 , A61K38/212 , C04B35/632 , C07D401/12 , C07D403/12 , C07D409/12 , C07D487/04 , C07D513/04 , C07K5/0217 , C07K5/0802 , A61K2300/00
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as pharmaceutical compositions comprising such compounds and methods of using them to treat disorders associated with the HCV protease. The novel compounds typically include a 15-20 member macrocycle and have the general structure of structural Formula (1): wherein Z', L', M', R1, X and D are defined herein.
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公开(公告)号：EP1664092B1
公开(公告)日：2011-02-02
申请号：EP04784827.0
申请日：2004-09-23
申请人： Schering Corporation
发明人： VENKATRAMAN, Srikanth , NJOROGE, F., George , WU, Wanli , GIRIJAVALLABHAN, Viyyoor, M. , MCKITTRICK, Brian , SU, Jing , VELAZQUEZ, Francisco , PINTO, Patrick, A.
IPC分类号： C07K5/12 , C07D245/00 , A61K38/12
CPC分类号： C07D245/04 , A61K31/33 , A61K38/12 , A61K38/21 , A61K38/212 , C04B35/632 , C07D401/12 , C07D403/12 , C07D409/12 , C07D487/04 , C07D513/04 , C07K5/0217 , C07K5/0802 , A61K2300/00
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as pharmaceutical compositions comprising such compounds and methods of using them to treat disorders associated with the HCV protease. The novel compounds typically include a 15-20 member macrocycle and have the general structure of structural Formula (1): wherein Z', L', M', R1, X and D are defined herein.
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公开(公告)号：EP2209796A1
公开(公告)日：2010-07-28
申请号：EP08845665.2
申请日：2008-10-29
申请人： Schering Corporation
发明人： VENKATRAMAN, Srikanth , NJOROGE, F., George , WU, Wanli , GIRIJAVALLABHAN, Viyyoor , MCKITTRICK, Brian , SU, Jing , VELAZQUEZ, Francisco , PINTO, Patrick, A.
CPC分类号： A61K31/541 , A61K31/439 , A61K31/4545 , A61K31/496 , A61K31/55 , A61K38/21 , A61K45/06 , C07K5/06026 , C07K5/0606 , C07K5/06069 , A61K2300/00
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
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7.发明公开
公开(公告)号：EP2197842A1
公开(公告)日：2010-06-23
申请号：EP08795611.6
申请日：2008-08-27
申请人： Schering Corporation
发明人： ANILKUMAR, Gopinadhan, N. , BENNETT, Frank , CHAN, Tin-Yau , CHEN, Kevin, X. , SANNIGRAHI, Mousumi , VELAZQUEZ, Francisco , VENKATRAMAN, Srikanth , ZENG, Qingbei , DUCA, Jose, S. , LESBURG, Charles, A. , KOZLOWSKI, Joseph, A. , NJOROGE, F., George , ROSENBLUM, Stuart, B. , SHIH, Neng-Yang , GAVALAS, Stephen, J. , JIANG, Yueheng , PINTO, Patrick, A. , PU, Haiyan , SELYUTIN, Oleg, B. , VIBULBHAN, Bancha , WANG, Li , WU, Wanli , YANG, Weiying , HUANG, Yuhua , HUANG, Hsueh-Cheng , PALERMO, Robert , FELD, Boris
IPC分类号： C07D209/42 , C07D401/04 , C07D401/14 , A61K31/404 , A61P31/12
CPC分类号： C07D417/14 , C07D209/42 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present invention relates to 2,3-Substituted Indole Derivatives, compositions comprising at least one 2,3-Substituted Indole Derivative, and methods of using the 2,3-Substituted Indole Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.
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公开(公告)号：EP1385870A2
公开(公告)日：2004-02-04
申请号：EP01954764.5
申请日：2001-07-19
发明人： SAKSENA, Anil, K. , GIRIJAVALLABHAN, Viyyoor, Moopil , LOVEY, Raymond, G. , JAO, Edwin, E. , BENNETT, Frank , MC CORMICK, Jinping, L. , WANG, Haiyan , PIKE, Russell, E. , BOGEN, Stephane, L. , CHAN, Tin-Yau , LIU, Yi-Tsung , ZHU, Zhaoning , NJOROGE, F., George , ARASAPPAN, Ashok , PAREKH, Tejal, N. , GANGULY, Ashit, K. , CHEN, Kevin, X. , VENKATRAMAN, Srikanth , VACCARO, Henry, A. , PINTO, Patrick A. , SANTHANAM, Bama , WU, Wanli , HENDRATA, Siska , HUANG, Yuhua , KEMP, Scott Jeffrey , LEVY, ODILE ESTHER , LIM-WILBY, Marguetita , TAMURA, Susan Y.
IPC分类号： C07K1/00
CPC分类号： C07K5/0202 , A61K38/00 , C07K5/0812 , C07K5/0827 , C07K7/02
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
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9.发明公开
公开(公告)号：EP2139854A2
公开(公告)日：2010-01-06
申请号：EP08826269.6
申请日：2008-03-20
申请人： Schering Corporation
发明人： VENKATRAMAN, Srikanth , NJOROGE, F., George , VELAZQUEZ, Francisco , WU, Wanli , MADISON, Vincent, S. , SHIH, Neng-Yang
IPC分类号： C07D207/16 , C07D401/12 , A61K31/401 , A61P31/12
CPC分类号： C07D207/16 , C07D401/12
摘要： The present invention discloses novel compounds, which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
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10.发明公开
公开(公告)号：EP1748983A2
公开(公告)日：2007-02-07
申请号：EP05723589.7
申请日：2005-02-24
申请人： SCHERING CORPORATION
发明人： VENKATRAMAN, Srikanth , NJOROGE, F., George , BLACKMAN, Melissa, L. , WU, Wanli , NAIR, Latha, G. , ARASAPPAN, Ashok , BOGEN, Stephane, L. , CHEN, Kevin, X. , SANNIGRAHI, Mousumi , BENNETT, Frank , GIRIJAVALLABHAN, Viyyoor, M.
IPC分类号： C07D209/52 , C07D403/12 , C07D401/12 , C07D417/12 , C07K5/08 , A61K31/40 , A61K31/4025 , A61K38/06 , A61P31/12
CPC分类号： C07D209/52 , A61K38/00 , C07D401/12 , C07D403/12 , C07D409/12 , C07D417/12 , C07K5/06034 , C07K5/06078
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
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