公开(公告)号：EP2123260A4

公开(公告)日：2010-03-17

申请号：EP07846229

申请日：2007-12-29

申请人： SHIJIAZHUANG PHARMA GROUP

发明人： LI CHUNLEI ,  WANG JINXU ,  WANG CAIXIA ,  LI YANHUI ,  SHEN DONGMIN ,  GUO WENMIN ,  ZHANG LI ,  ZHANG LAN

IPC分类号： A61K9/127 ,  A61K31/136 ,  A61K31/4375 ,  A61K31/475 ,  A61K47/24 ,  A61P35/00

CPC分类号： A61K9/1273 ,  A61K9/1271 ,  A61K31/136 ,  A61K31/704

摘要： A liposomal pharmaceutical formulation comprising multivalent ionic drug, a process for the preparation thereof, and the use thereof in the treatment of diseases, wherein the particle size of the liposome is about 30-80 nm, and the phospholipid bilayer contains a phospholipid with Tm> body temperature thereby the phase transition of the liposome is above body temperature.