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1.发明公开SYNTHESIS OF CARBAMOYLPYRIDONE HIV INTEGRASE INHIBITORS AND INTERMEDIATES 有权合成CARBAMOYLPYRIDON-HIV整合酶抑制剂及中间体
公开(公告)号：EP2376080A4
公开(公告)日：2012-07-11
申请号：EP09832226
申请日：2009-12-08
申请人： SHIONOGI & CO , GLAXOSMITHKLINE LLC
IPC分类号： A61K31/4412 , A61K31/351 , C07D471/00 , C07D491/00 , C07D498/00
CPC分类号： C07D498/14 , A61K31/351 , A61K31/4412 , C07D213/803 , C07D213/81 , C07D471/22 , C07D487/22 , Y02P20/55
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公开(公告)号：EP2330902A4
公开(公告)日：2011-08-17
申请号：EP09800993
申请日：2009-07-23
申请人： GLAXOSMITHKLINE LLC , SHIONOGI & CO
发明人： JOHNS BRIAN ALVIN , WEATHERHEAD JASON GORDON , AOYAMA YASUNORI , YOSHIDA HIROSHI , TAODA YOSHIYUKI
IPC分类号： A01N43/42 , A61K31/44 , C07D471/14
CPC分类号： C07D471/14
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3.发明公开POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING INHIBITORY ACTIVITY ON HIV INTEGRASE 有权有锁定效应对HIV整合多环芳烃CARBAMOYLPYRIDONDERIVAT
公开(公告)号：EP1950212A4
公开(公告)日：2010-08-04
申请号：EP06822311
申请日：2006-10-26
申请人： SHIONOGI & CO
IPC分类号： A61K31/403 , A61K31/495 , A61K31/50 , A61K31/519 , C07D239/00 , C07D241/36 , C07D471/00 , C07D487/00 , C07D495/00 , C07D497/00
CPC分类号： C07F9/6561 , C07D471/04 , C07D471/14 , C07D471/20 , C07D498/14
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4.发明公开CARBAMOYLPYRIDONE DERIVATIVE HAVING HIV INTEGRASE INHIBITORY ACTIVITY 有权与HIV整合LOCKING活动CARBAMOYLPYRIDON衍生物
公开(公告)号：EP1790638A4
公开(公告)日：2009-10-28
申请号：EP05783196
申请日：2005-09-14
申请人： SHIONOGI & CO
发明人： YOSHIDA HIROSHI
IPC分类号： C07D213/82 , A61K31/366 , A61K31/455 , A61K31/506 , A61K31/5377 , A61P31/14 , A61P31/18 , C07D309/38 , C07D401/06 , C07D401/12 , C07D405/04 , C07D409/12 , C07D413/04 , C07D417/04
CPC分类号： C07D213/82 , C07D213/81 , C07D401/06 , C07D401/12 , C07D409/12
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公开(公告)号：EP1541558A4
公开(公告)日：2005-08-17
申请号：EP03795216
申请日：2003-08-11
申请人： SHIONOGI & CO
IPC分类号： A61P31/18 , A61P37/04 , A61P43/00 , C07D215/48 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/06 , C07D417/12 , C07D471/04 , C07D491/052 , C07D493/04 , A61K31/4375 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/5377
CPC分类号： C07D215/48 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/06 , C07D417/12 , C07D471/04 , C07D493/04
摘要： A compound having antiviral activity, specifically a heterocyclic compound having HIV integrase inhibitory activity; and a medicine containing the compound, especially an anti-HIV drug. The compound is a compound represented by the formula (I): (I) [wherein B1 is -C(R2)= or -N=; R1' is hydrogen, etc.; one of R1 and R2 is a group represented by the formula -Z1-Z2-Z3-R5 (wherein Z1 and Z3 each independently is a single bond, optionally substituted alkylene, etc.; Z2 is a single bond, optionally substituted alkylene, etc.; and R5 is optionally substituted aryl, optionally substituted heteroaryl, etc.) and the other is hydrogen; and -A1- is -C(-Y)=C(-RA)-C(-R3)=C(-R4)- (wherein Y is -OH, etc.; RA is -COR7 (R7 is hydroxy, etc.), etc.; and one of R3 and R4 is carboxy, etc. and the other is hydrogen, etc.), etc.], a prodrug of the compound, a pharmaceutically acceptable salt of either, or a solvate of any of these.
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6.发明公开BICYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING HIV INTEGRASE INHIBITING ACTIVITY 有权BICYCLISCHES CARBAMOYLPYRIDONDERIVAT MIT HIV-INTEGRASE-HEMMENDER WIRKUNG
公开(公告)号：EP1852434A4
公开(公告)日：2010-01-13
申请号：EP06714066
申请日：2006-02-20
申请人： SHIONOGI & CO
IPC分类号： A61K31/403 , A61K31/495 , A61K31/50 , A61K31/519 , C07D239/00 , C07D241/36 , C07D471/00 , C07D487/00 , C07D495/00 , C07D497/00
CPC分类号： C07D471/04 , C07F9/6561
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