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公开(公告)号：EP2263085A4
公开(公告)日：2011-07-06
申请号：EP09731410
申请日：2009-03-04
Applicant: SINGULEX INC
Inventor： GOIX PHILIPPE J , PUSKAS ROBERT , TODD JOHN , LIVINGSTON RICHARD A , HELD DOUGLAS , LE SARA
IPC: G01N33/53
CPC classification number: G01N33/577 , A61B5/00 , A61B5/0402 , A61B5/412 , A61B5/415 , A61B5/418 , A61B5/7264 , A61B5/7275 , G01N21/6428 , G01N33/582 , G01N33/6863 , G01N33/6869 , G01N33/6872 , G01N33/6887 , G01N33/6896 , G01N33/74 , G01N33/92 , G01N2333/4712 , G01N2333/475 , Y02A90/26 , Y10T436/143333
Abstract: The present invention discloses methods for the detection and monitoring of a condition in a subject using highly sensitive detection of molecules. The invention provides a method for detecting or monitoring a condition in a subject, comprising detecting a first marker in a first sample from the subject and detecting a second marker, wherein the first marker comprises a biomarker, e.g., Cardiac Troponin-I (cTnI) or Vascular Endothelial Growth Factor (VEGF), and wherein the limit of detection of the first marker is less than about 10 pg/ml. The second marker can be a biomarker, physiological marker, a molecular marker or a genetic marker.
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2.发明公开METHODS AND COMPOSITIONS FOR HIGHLY SENSITIVE ANALYSIS OF MARKERS AND DETECTION OF MOLECULES 审中-公开方法和组合物用于分子的检测高敏感性分析和标记
公开(公告)号：EP2016394A4
公开(公告)日：2013-04-24
申请号：EP07861282
申请日：2007-04-04
Applicant: SINGULEX INC
Inventor： GOIX PHILIPPE , PUSKAS ROBERT , TODD JOHN , LIVINGSTON RICHARD , HELD DOUGLAS
CPC classification number: G01N33/6887 , G01N15/06 , G01N15/1459 , G01N21/6428 , G01N33/577 , G01N33/582 , G01N2015/0693 , G01N2015/1006 , G01N2015/1486 , G01N2201/1247 , G01N2201/12761 , G01N2800/32 , G01N2800/324 , G01N2800/52 , Y10T436/105831
Abstract: The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin. Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin.
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3.发明公开
公开(公告)号：EP2002260A4
公开(公告)日：2009-08-05
申请号：EP07754941
申请日：2007-04-04
Applicant: SINGULEX INC
Inventor： GOIX PHILIPPE , PUSKAS ROBERT , TODD JOHN , LIVINGSTON RICHARD , HELD DOUGLAS
IPC: G01N33/53
CPC classification number: G01N33/6887 , G01N15/06 , G01N15/1459 , G01N21/6428 , G01N33/577 , G01N33/582 , G01N2015/0693 , G01N2015/1006 , G01N2015/1486 , G01N2201/1247 , G01N2201/12761 , G01N2800/32 , G01N2800/324 , G01N2800/52 , Y10T436/105831
Abstract: The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin. Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin.
Abstract translation: 本发明提供用于敏感检测心肌肌钙蛋白的方法，组合物，试剂盒和系统。 这些方法，组合物，试剂盒和系统可用于涉及心肌肌钙蛋白释放的病症中的治疗方法的诊断，预后和测定。
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公开(公告)号：EP2440936A4
公开(公告)日：2013-03-13
申请号：EP10786631
申请日：2010-06-07
Applicant: SINGULEX INC
Inventor： GOIX PHILIPPE J , PUSKAS ROBERT , TODD JOHN , LIVINGSTON RICHARD , HELD DOUGLAS , LE SARA
CPC classification number: G01N33/6869 , G01N33/6893 , G01N2333/32 , G01N2333/47 , G01N2333/4712 , G01N2333/525 , G01N2333/54 , G01N2333/5412 , G01N2333/58 , G01N2800/32 , G01N2800/325 , G01N2800/60
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