公开(公告)号：EP2263085A4

公开(公告)日：2011-07-06

申请号：EP09731410

申请日：2009-03-04

Applicant: SINGULEX INC

Inventor： GOIX PHILIPPE J ,  PUSKAS ROBERT ,  TODD JOHN ,  LIVINGSTON RICHARD A ,  HELD DOUGLAS ,  LE SARA

IPC: G01N33/53

CPC classification number: G01N33/577 ,  A61B5/00 ,  A61B5/0402 ,  A61B5/412 ,  A61B5/415 ,  A61B5/418 ,  A61B5/7264 ,  A61B5/7275 ,  G01N21/6428 ,  G01N33/582 ,  G01N33/6863 ,  G01N33/6869 ,  G01N33/6872 ,  G01N33/6887 ,  G01N33/6896 ,  G01N33/74 ,  G01N33/92 ,  G01N2333/4712 ,  G01N2333/475 ,  Y02A90/26 ,  Y10T436/143333

Abstract: The present invention discloses methods for the detection and monitoring of a condition in a subject using highly sensitive detection of molecules. The invention provides a method for detecting or monitoring a condition in a subject, comprising detecting a first marker in a first sample from the subject and detecting a second marker, wherein the first marker comprises a biomarker, e.g., Cardiac Troponin-I (cTnI) or Vascular Endothelial Growth Factor (VEGF), and wherein the limit of detection of the first marker is less than about 10 pg/ml. The second marker can be a biomarker, physiological marker, a molecular marker or a genetic marker.

公开(公告)号：EP2232271A4

公开(公告)日：2014-12-10

申请号：EP08873367

申请日：2008-12-18

Applicant: SINGULEX INC

Inventor： LIVINGSTON RICHARD A

IPC: G01N35/00 ,  B01L3/00 ,  G01N15/00 ,  G01N15/14 ,  G01N21/64 ,  G01N33/53

CPC classification number: G01N21/6428 ,  B01L3/5085 ,  B01L2300/0654 ,  B01L2300/0829 ,  G01N15/14 ,  G01N15/1434 ,  G01N15/1456 ,  G01N15/1463 ,  G01N21/00 ,  G01N21/01 ,  G01N21/64 ,  G01N21/645 ,  G01N33/53 ,  G01N2015/0038 ,  G01N2015/1447 ,  G01N2015/1452 ,  G01N2201/02 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/0697

Abstract: The invention encompasses analyzers and analyzer systems that include a single molecule analyzer, methods of using the analyzer and analyzer systems to analyze samples, either for single molecules or for molecular complexes. The single molecule uses electromagnetic radiation that is translated through the sample to detect the presence or absence of a single molecule. The single molecule analyzer provided herein is useful for diagnostics because the analyzer detects single molecules with zero carryover between samples.

Abstract translation: 本发明包括分析仪和分析仪系统，其包括单分子分析仪，使用分析仪和分析仪系统分析样品的单分子或分子复合物的方法。 单分子使用通过样品翻译的电磁辐射来检测单个分子的存在或不存在。 本文提供的单分子分析仪可用于诊断，因为分析仪检测到样品之间具有零携带的单分子。

公开(公告)号：EP1805500A4

公开(公告)日：2008-05-07

申请号：EP05757239

申请日：2005-01-28

Applicant: SINGULEX INC

Inventor： PUSKAS ROBERT ,  GOIX PHILIPPE ,  LIVINGSTON RICHARD A ,  HELD DOUGLAS D ,  KLEIN BARBARA ,  FUKUSHIMA NOELLE ,  FREESE ROBERT ,  DAVID PETER ,  URDEA MICKEY

IPC: G01N21/00 ,  G01N21/03 ,  G01N21/75 ,  G01N21/76

CPC classification number: G01N35/1095 ,  G01N1/28 ,  G01N15/1459 ,  G01N21/6428 ,  G01N27/447 ,  G01N33/68 ,  G01N33/6803 ,  G01N33/6845 ,  G01N2015/1438 ,  G01N2035/1034

Abstract: The invention encompasses analyzers and analyzer systems that include a single particle analyzer, methods of using the analyzers and analyzers systems to analyze samples, either for single particles of for multiple particles (multiplexing), methods of doing business based on the use of the analyzers or analyzer systems of the system, and electronic media for storing parameters useful in the analyzers and analyzer systems of the invention.