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15 条记录 (耗时 0.019 秒)

    VERFAHREN ZUR ERKENNUNG VON SEPSIS
    1.
    发明授权
    VERFAHREN ZUR ERKENNUNG VON SEPSIS 有权
    检测方法的败血症

    公开(公告)号：EP1721002B1

    公开(公告)日：2010-02-24

    申请号：EP04803924.2

    申请日：2004-12-15

    申请人： SIRS-Lab GmbH

    发明人： RUSSWURM, Stefan ,  DEIGNER, Hans-Peter

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6876 ,  B82Y5/00 ,  B82Y10/00 ,  C12Q1/6837 ,  C12Q2600/158 ,  Y10T436/143333

    摘要： The invention relates to a method for the in vitro distinction between systemic inflammatory non-infectious conditions and systemic inflammatory infectious conditions. Said method comprises the following steps: a) sample RNA is isolated from a biological sample; b) the sample RNA and/or at least one DNA which represents a gene activity that is specific for distinguishing between SIRS and sepsis and/or a specific gene or gene fragment, is marked with a detectable marker; c) the sample RNA is brought in contact with the DNA in hybridization conditions; d) control RNA is brought in contact with at least one DNA in hybridization conditions, said DNA representing a gene or gene fragment that is specific for distinguishing between SIRS and sepsis; e) the marking signals of the hybridized sample RNA and control RNA are quantitatively recorded; and f) the quantitative data of the marking signals is compared in order to make a statement as to whether genes or gene fragments that are specific for distinguishing between SIRS and sepsis are expressed more prominently or less prominently in the sample than in the control RNA.

    VERFAHREN ZUR IN-VITRO -DIAGNOSE VON CHLAMYDOPHILA PNEUMONIAE INFEKTIONEN
    2.
    发明公开
    VERFAHREN ZUR IN-VITRO -DIAGNOSE VON CHLAMYDOPHILA PNEUMONIAE INFEKTIONEN 审中-公开
    程序对体外诊断衣原体肺炎感染的

    公开(公告)号：EP1974217A2

    公开(公告)日：2008-10-01

    申请号：EP07703040.1

    申请日：2007-01-25

    申请人： SIRS-Lab GmbH

    发明人： RUSSWURM, Stefan ,  OSTERLOH, Dirk

    IPC分类号： G01N33/569 ,  A61K39/118 ,  A61K39/42 ,  C12Q1/42

    CPC分类号： G01N33/56927 ,  G01N2333/295

    摘要： The invention relates to a method for the in vitro diagnosis of a Chlamydia pneumoniae-specific infection. Said method is characterized in that the presence of at least one of the proteins dnaJ and hydrolase/phosphatase homolog and/or derivatives thereof and/or at least one antibody directed against said proteins and/or derivatives thereof is detected in a patient's sample. Also disclosed are a kit for carrying out the in vitro diagnostic method as well as the preventive and therapeutic use of said biomarkers.

    VERFAHREN ZUR UNTERSCHEIDUNG ZWISCHEN NICHTINFEKTIÖSEN UND INFEKTIÖSEN URSACHEN EINES MULTIORGANVERSAGENS
    5.
    发明公开
    VERFAHREN ZUR UNTERSCHEIDUNG ZWISCHEN NICHTINFEKTIÖSEN UND INFEKTIÖSEN URSACHEN EINES MULTIORGANVERSAGENS 审中-公开
    PROCESS FOR之间的多个器官功能衰竭NOT感染性和传染性病因的区别

    公开(公告)号：EP1799848A1

    公开(公告)日：2007-06-27

    申请号：EP05775921.9

    申请日：2005-08-18

    申请人： SIRS-Lab GmbH

    发明人： RUSSWURM, Stefan ,  REINHART, Konrad

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6883 ,  C12Q2600/158

    摘要： The invention relates to the use of gene expression profiles obtained in vitro from patient samples for differentiating between the non-infectious and infectious causes of multiple organ failure. The invention also relates to a method for measuring gene expression profiles in vitro and to the use of said gene expression profiles and/or of the probes used therein for screening active substances against the non-infectious and/or infectious causes of multiple organ failure.

    VERFAHREN ZUR IN-VITRO ÜBERWACHUNG POSTOPERATIVER VERÄNDERUNGEN NACH LEBERTRANSPLANTATION
    9.
    发明公开
    VERFAHREN ZUR IN-VITRO ÜBERWACHUNG POSTOPERATIVER VERÄNDERUNGEN NACH LEBERTRANSPLANTATION 审中-公开
    程序的体外监测术后更改后，肝脏移植

    公开(公告)号：EP2032718A2

    公开(公告)日：2009-03-11

    申请号：EP07723651.1

    申请日：2007-04-11

    申请人： SIRS-Lab GmbH

    发明人： RUSSWURM, Stefan

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6883 ,  C12Q2600/118 ,  C12Q2600/158

    摘要： The present invention relates to the use of gene expression profiles, obtained in vitro from a patient sample, for detecting any postoperative tissue incompatibility reactions following a liver transplantation, wherein in patients the gene activity of a plurality of specific genes relevant to a liver transplantation is determined in a patient sample, and the specific genes and/or gene fragments for monitoring of postoperative states are selected from the group consisting of: SEQ-ID No. 1 to SEQ-ID No. 532, these preferably being subdivided into several clusters.