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公开(公告)号：EP1156804A1
公开(公告)日：2001-11-28
申请号：EP99968146.3
申请日：1999-12-17
IPC分类号： A61K31/415 , A61K31/27
CPC分类号： A61K31/655 , C07D231/46
摘要： Invented are non-peptide TPO mimetics. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azo-naphthalene derivative.
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公开(公告)号：EP1349613A2
公开(公告)日：2003-10-08
申请号：EP01987514.5
申请日：2001-12-19
发明人： DUFFY, Kevin, J. , LUENGO, Juan, I. , MILLER, Stephen, G. , JENKINS, Julian , PRICE, Alan, T. , SHAW, Antony, N.
IPC分类号： A61P7/00 , A61K35/16 , A61K31/045 , A61K31/05 , A61K31/13 , A61K31/131 , A61K31/04 , A61K35/28 , A61K35/54
CPC分类号： A61K31/275 , A61K31/04 , A61K31/045 , A61K31/05 , A61K31/13 , A61K31/131 , A61K31/175 , A61K31/325 , A61K31/415
摘要： Invented are non-peptide TPO mimetics. also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected substituted thiosemicarbazone derivative.
摘要翻译： 发明的是非肽TPO模拟物。 还发明了一种治疗有需要的哺乳动物，包括人的血小板减少症的方法，该方法包括给予这种哺乳动物有效量的选择的取代的缩氨基硫脲衍生物。
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公开(公告)号：EP1294378B1
公开(公告)日：2007-10-03
申请号：EP01941599.1
申请日：2001-05-24
发明人： DUFFY, Kevin, J. , ERICKSON-MILLER, Connie, L. , EPPLEY, Daniel, F. , JENKINS, Julian , LUENGO, Juan, I. , LIU, Nannan , PRICE, Alan, T. , SHAW, Antony, N. , VISONNEAU, Sophie , WIGGALL, Kenneth
IPC分类号： C07D417/12 , C07D231/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D417/04 , A61K31/4439 , A61K31/415 , A61K31/506
CPC分类号： C07D403/12 , C07D231/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D417/04 , C07D417/12
摘要： Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.
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公开(公告)号：EP0920314B1
公开(公告)日：2003-08-27
申请号：EP97928663.0
申请日：1997-05-22
IPC分类号： A61K31/415 , C07D235/00
CPC分类号： C07D487/04
摘要： Invented are non-peptide G-CSF mimetics. Also invented are substitued 2,5-Diimino-3a,6a-diaryl-1,2,3,3a,4,5,6,6a-octahydroimidazo[4,5-d]imidazoles, pharmaceutical compositions containing these compounds, and methods of using these compounds as G-CSF mimetics. Also invented are novel processes used in preparing these compounds.
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公开(公告)号：EP1294378A2
公开(公告)日：2003-03-26
申请号：EP01941599.1
申请日：2001-05-24
发明人： DUFFY, Kevin, J. , ERICKSON-MILLER, Connie, L. , EPPLEY, Daniel, F. , JENKINS, Julian , LUENGO, Juan, I. , LIU, Nannan , PRICE, Alan, T. , SHAW, Antony, N. , VISONNEAU, Sophie , WIGGALL, Kenneth
IPC分类号： A61K31/41 , A61K31/4152 , A61K31/44 , A61K31/4709 , A61K31/655 , C07D213/79 , C07D231/20 , C07D257/04 , C07D401/02 , C07D403/02 , C07D405/04 , C07D409/04
CPC分类号： C07D403/12 , C07D231/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D417/04 , C07D417/12
摘要： Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.
摘要翻译： 发明的是非肽TPO模拟物。 还发明了用于制备目前发明的化合物的新型方法和中间体。 还发明了一种治疗需要治疗的哺乳动物包括人的血小板减少症的方法，该方法包括给予这种哺乳动物有效量的选择的羟基-1-偶氮苯衍生物。
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公开(公告)号：EP1223944A1
公开(公告)日：2002-07-24
申请号：EP00965329.6
申请日：2000-09-22
发明人： DUFFY, Kevin, J. , LUENGO, Juan, I. , LIU, Nannan
IPC分类号： A61K31/655 , C07D231/22 , C07D231/26 , C07D231/38
CPC分类号： C07D401/14 , C07D231/48
摘要： Invented are non-peptide TPO mimetics. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected azo-pyrazole derivative.
摘要翻译： 发明的是非肽TPO模拟物。 还发明了一种治疗有需要的哺乳动物包括人的血小板减少症的方法，该方法包括给予这种哺乳动物有效量的选择的偶氮 - 吡唑衍生物。
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公开(公告)号：EP1742924A1
公开(公告)日：2007-01-17
申请号：EP05744198.2
申请日：2005-05-03
IPC分类号： C07D239/36 , C07D239/91 , A61K31/513 , A61K31/517
CPC分类号： C07D239/91
摘要： Novel calcilytic compounds and methods of using them are provided.
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公开(公告)号：EP1133291B1
公开(公告)日：2006-01-11
申请号：EP99960442.4
申请日：1999-11-17
发明人： LUENGO, Juan, I. , LAMB, Peter, I.
IPC分类号： A61K31/33 , A61K31/555 , A61P7/00
CPC分类号： A61K31/33 , A61K31/395 , A61K31/555
摘要： Invented are non-peptide TPO mimetics. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a linked cyclic polyamine derivative.
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公开(公告)号：EP1370252A1
公开(公告)日：2003-12-17
申请号：EP02728383.7
申请日：2002-03-01
IPC分类号： A61K31/04 , A61K31/135 , A61K31/415 , C07C63/08 , C07C63/64 , C07D231/18 , C07D257/04
CPC分类号： A61K31/135 , A61K31/04 , A61K31/415 , C07D231/20
摘要： Invented are non-peptide TPO mimetics. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.
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10.发明公开
公开(公告)号：EP1351979A1
公开(公告)日：2003-10-15
申请号：EP01988426.1
申请日：2001-12-19
发明人： DELORME, Evelyn, O. , DUFFY, Kevin, J. , LAMB, Peter, I. , LUENGO, Juan, I. , TIAN, Shin-Shay, C.
CPC分类号： C07K14/715 , C07K14/7153
摘要： Invented is a regulated activation of cell-membrane receptors by small molecule agents. Also invented is a method to render a cell-membrane receptor responsive to the activation by small molecule compounds by specific single point mutations in the transmembrane region.
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