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公开(公告)号：EP1070048B1
公开(公告)日：2005-08-31
申请号：EP99916516.0
申请日：1999-04-08
发明人： BHATNAGAR, Pradip, Kumar , BURGESS, Joelle, Lorraine , CALLAHAN, James, Francis , CALVO, Raul, Rolando , DEL MAR, Eric, G. , LAGO, Maria, Amparo , NGUYEN, Thomas, The
IPC分类号： C07C255/33 , C07C217/56 , C07C217/32 , C07C255/55 , C07C217/90 , C07C311/06 , C07D209/48 , A61K31/195 , A61K31/275 , A61K31/40 , A61K31/135 , A61K31/215
CPC分类号： C07D209/48 , C07C217/22 , C07C217/60 , C07C255/37 , C07C255/54 , C07C255/57 , C07C311/06
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公开(公告)号：EP0973730B1
公开(公告)日：2004-06-16
申请号：EP98914581.8
申请日：1998-04-08
发明人： BARMORE, Robert, M. , BHATNAGAR, Pradip, Kumar , BRYAN, William, M. , BURGESS, Joelle, Lorraine , CALLAHAN, James, Francis , CALVO, Raul, Rolando , DEL MAR, Eric, G. , LAGO, Maria Amparo , NGUYEN, Thomas, The , SHEEHAN, Derek , SMITH, Robert, Lawrence , SOUTHALL, Linda, Sue , VAN WAGENEN, Bradford, C.
IPC分类号： C07C321/22 , C07C311/20 , C07C311/16 , C07C311/08 , C07C255/56 , C07C255/54 , C07C217/58 , C07C217/34 , C07C217/36 , C07D295/26 , C07D295/18 , C07D295/104 , C07D295/092 , C07D267/20 , A61P19/08 , A61P19/10 , A61K31/18 , A61K31/165
CPC分类号： C07D295/192 , C07C255/57 , C07C311/08 , C07C311/21 , C07C311/29 , C07C323/17 , C07C2601/02 , C07C2603/32 , C07D267/20 , C07D295/215
摘要： Novel arylalkylamino compounds exhibiting calcilytic properties are provided.
摘要翻译： 提供了具有钙质特性的新型芳基烷基氨基化合物。
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公开(公告)号：EP1070048A1
公开(公告)日：2001-01-24
申请号：EP99916516.0
申请日：1999-04-08
发明人： BHATNAGAR, Pradip, Kumar , BURGESS, Joelle, Lorraine , CALLAHAN, James, Francis , CALVO, Raul, Rolando , DEL MAR, Eric, G. , LAGO, Maria, Amparo , NGUYEN, Thomas, The
IPC分类号： C07C255/33
CPC分类号： C07D209/48 , C07C217/22 , C07C217/60 , C07C255/37 , C07C255/54 , C07C255/57 , C07C311/06
摘要： Novel calcilytic compounds, pharmaceutical compositions containing said compounds and their use as calcium receptor antagonists.
摘要翻译： 新型钙溶解化合物，含有所述化合物的药物组合物及其作为钙受体拮抗剂的用途。
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公开(公告)号：EP1254106B1
公开(公告)日：2009-02-25
申请号：EP01910349.8
申请日：2001-01-24
发明人： LAGO, Amparo M. , CALLAHAN, James, Francis , BHATNAGAR, Pradip, Kumar , DEL MAR, Eric, G. , BRYAN, William, M. , BURGESS, Joelle, L.
IPC分类号： C07C255/50 , A61K31/277
CPC分类号： C07D303/22 , C07C69/616 , C07C69/738 , C07C211/30 , C07C233/05 , C07C251/48 , C07C255/57 , C07C255/58 , C07C2602/08 , C07C2602/10
摘要： Novel calcilytic compounds and methods of using them are provided.
摘要翻译： 提供了新的钙质化合物及其使用方法。
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公开(公告)号：EP1254106A1
公开(公告)日：2002-11-06
申请号：EP01910349.8
申请日：2001-01-24
发明人： LAGO, Amparo M. , CALLAHAN, James, Francis , BHATNAGAR, Pradip, Kumar , DEL MAR, Eric, G. , BRYAN, William, M. , BURGESS, Joelle, L.
IPC分类号： C07C255/50 , A61K31/277
CPC分类号： C07D303/22 , C07C69/616 , C07C69/738 , C07C211/30 , C07C233/05 , C07C251/48 , C07C255/57 , C07C255/58 , C07C2602/08 , C07C2602/10
摘要： Novel calcilytic compounds and methods of using them are provided.
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公开(公告)号：EP1069901A1
公开(公告)日：2001-01-24
申请号：EP99917374.3
申请日：1999-04-08
IPC分类号： A61K31/535 , A01N43/02 , A01N43/40 , A01N43/42 , C07D211/70 , C07D211/72 , C07D217/12 , C07D217/16 , C07D217/18 , C07D307/02
CPC分类号： C07D307/79 , C07C255/54 , C07D213/38 , C07D215/12 , C07D217/14
摘要： Calcilytic compounds and compositions and their use in treating abnormal bone or mineral homeostasis.
摘要翻译： 钙溶解化合物和组合物及其在治疗异常骨或矿物质平衡中的用途。
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公开(公告)号：EP0973730A1
公开(公告)日：2000-01-26
申请号：EP98914581.8
申请日：1998-04-08
发明人： BARMORE, Robert, M. , BHATNAGAR, Pradip, Kumar , BRYAN, William, M. , BURGESS, Joelle, Lorraine , CALLAHAN, James, Francis , CALVO, Raul, Rolando , DEL MAR, Eric, G. , LAGO, Maria Amparo , NGUYEN, Thomas, The , SHEEHAN, Derek , SMITH, Robert, Lawrence , SOUTHALL, Linda, Sue , VAN WAGENEN, Bradford, C.
IPC分类号： C07C255/07 , C07C311/03 , C07C229/04 , C07C69/76 , C07C69/74 , C07D223/08 , C07D243/12 , C07D273/04 , C07D265/30 , C07D295/092 , C07D413/08
CPC分类号： C07D295/192 , C07C255/57 , C07C311/08 , C07C311/21 , C07C311/29 , C07C323/17 , C07C2601/02 , C07C2603/32 , C07D267/20 , C07D295/215
摘要： Novel arylalkylamino compounds exhibiting calcilytic properties are provided.
摘要翻译： 提供了表现出钙溶解性质的新型芳基烷基氨基化合物。
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公开(公告)号：EP0637237A1
公开(公告)日：1995-02-08
申请号：EP93907015.0
申请日：1993-02-23
发明人： NEMETH, Edward, F. , BROWN, Edward, M. , HEBERT, Steven, C. , VAN WAGENEN, Bradford, C. , BALANDRIN, Manuel, F. , FULLER, Forrest, H. , DEL MAR, Eric, G.
CPC分类号： A61K31/70 , A01K2217/05 , A01K2217/075 , A01K2217/30 , A01K2227/10 , A01K2267/03 , A61K31/00 , A61K31/13 , A61K31/135 , A61K31/165 , A61K31/195 , A61K31/235 , A61K31/275 , A61K31/395 , A61K31/40 , A61K31/415 , A61K31/44 , A61K31/55 , C07K14/705 , C07K2319/00 , C12N15/8509
摘要： Method and composition useful for treating a patient having a disease characterized by an abnormal level of one or more components, the activity of which is regulated or affected by activity of one or more inorganic-ion receptor. Novel compounds useful in these methods and compositions are also provided. The method includes administering to the patient a therapeutically effective amount of a molecule active at one or more inorganic-ion receptors as an agent or antagonist. Preferably, the molecule is able to act as either a selective agonist or antagonist at a Ca2+ receptor of one or more but not all cells chosen from the group consisting of parathyroid cells, bone osteoclasts, juxtaglomerular kidney cells, proximal tubule kidney cells, distal tubule kidney cell, cell of the thick ascending limb of Henle's loop and/or collecting duct, keratinocyte in the epidermis, parafollicular cell in the thyroid (C-cells), intestinal cell, trophoblast in the placenta, platelet, vascular smooth muscle cell, cardiac atrial cell, gastrin and glucagon secreting cells, kidney mesangial cell and mammary cell.
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公开(公告)号：EP0901459B1
公开(公告)日：2005-06-29
申请号：EP97917848.0
申请日：1997-04-04
发明人： VAN WAGENEN, Bradford, C. , DEL MAR, Eric, G. , SHEEHAN, Derek , BARMORE, Robert, M. , KEENAN, Richard, M. , KOTECHA, Nikesh, R. , THOMPSON, Mervyn , CALLAHAN, James, F.
IPC分类号： C07C217/34 , C07C217/14 , C07C217/28 , A61K31/135 , A61K31/44 , A61K31/395 , A61K31/38
CPC分类号： C07C311/29 , A61K31/137 , A61K31/18 , A61K31/277 , C07C217/30 , C07C217/60 , C07C217/62 , C07C255/46 , C07C255/54 , C07C323/25 , C07C2601/14 , C07C2603/74 , C07D213/65 , C07D317/58 , C07D333/70
摘要： The present invention features calcilytic compounds. 'Calcilytic compounds' refer to compounds able to inhibit calcium receptor activity. Also described are the use of calcilytic compounds to inhibit calcium receptor activity and/or achieve a beneficial effect in a patient; and techniques which can be used to obtain additional calcilytic compounds.
摘要翻译： 本发明具有钙化合物。 “钙化合物”是指能够抑制钙受体活性的化合物。 还描述了使用钙化合物抑制钙受体活性和/或在患者中获得有益效果; 以及可用于获得额外的钙化合物的技术。
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公开(公告)号：EP0901459A1
公开(公告)日：1999-03-17
申请号：EP97917848.0
申请日：1997-04-04
发明人： VAN WAGENEN, Bradford, C. , DEL MAR, Eric, G. , SHEEHAN, Derek , BARMORE, Robert, M. , KEENAN, Richard, M. , KOTECHA, Nikesh, R. , THOMPSON, Mervyn , CALLAHAN, James, F.
IPC分类号： G01N33 , A61K31 , A61P19 , C07C217 , C07C255 , C07C311 , C07C323 , C07D209 , C07D213 , C07D317 , C07D333
CPC分类号： C07C311/29 , A61K31/137 , A61K31/18 , A61K31/277 , C07C217/30 , C07C217/60 , C07C217/62 , C07C255/46 , C07C255/54 , C07C323/25 , C07C2601/14 , C07C2603/74 , C07D213/65 , C07D317/58 , C07D333/70
摘要： The present invention features calcilytic compounds. 'Calcilytic compounds' refer to compounds able to inhibit calcium receptor activity. Also described are the use of calcilytic compounds to inhibit calcium receptor activity and/or achieve a beneficial effect in a patient; and techniques which can be used to obtain additional calcilytic compounds.
摘要翻译： 本发明的特征在于钙溶胶化合物。 “Calcilytic化合物”是指能够抑制钙受体活性的化合物。 还描述了钙溶解化合物在患者中抑制钙受体活性和/或实现有益作用的用途; 和可用于获得额外的钙溶解化合物的技术。
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