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1.发明公开HUMAN RECEPTOR GPR14, AND A METHOD OF FINDING AGONIST AND ANTAGONIST TO HUMAN AND RAT GPR14 审中-公开人类受体GPR14和方法用于搜索激动剂和拮抗剂人和大鼠GPR14受体
公开(公告)号：EP1056844A1
公开(公告)日：2000-12-06
申请号：EP99903409.3
申请日：1999-01-27
申请人： SMITHKLINE BEECHAM CORPORATION , SMITHKLINE BEECHAM PLC , Smithkline BeechamLaboratoires Pharmaceutiques
发明人： DOUGLAS, Stephen, A.,B202 La Maison Apartments , WILLETTE, Robert, N. , AIYAR, Nambi, V. , ARNOLD, Anne, Romanic , KHANDOUDI, Nassirah , GOUT, Bernard , AL-BARAZANJI, Kamal , AMES, Robert, S. , FOLEY, James, J. , SARAU, Henry, M. , CHAMBERS, Jon , SHABON, Usman , BERGSMA, Derk, J.
CPC分类号： C07K14/705 , A61K38/00 , A61K48/00 , C07K14/723
摘要： Human GPR14 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Human GPR14 polypeptides and polynucleotides in the design of protocols for the treatment of ischemic coronary artery disease (angina and myocardial infarction); atherosclerosis; metabolic diseases (e.g. diabetes); CHF/myocardial dysfunction; arrhythmias; restenosis; hypertension; hypotension; pulmonary disease (hypertension, COPD, asthma); fibrotic vasculopathies (diabetes, SLE, AS, Reynaud's); cerebrovascular events (e.g. hemnorrhagic and ischemic stroke); neurogenic inflammation/migraine; hematopoietic disorders; ARDS; cancer; autoimmune diseases (e.g. HIV-1 and -2 infection and AIDS); gastrointestinal and genitourinary disturbances (e.g. ulcers); endocrine disorders; fibroproliferative disorders (e.g. psoriasis); inflammatory disease (e.g. RA, Crohn's, IBS); benign prostatic hypertrophy; renal failure and glomerulopathies; disease states, both cardiovascular and non-cardiovascular, which are characterized by excessive vasoconstriction, myocardial dysfunction and/or aberrant fibroproliferative/inflammatory responses; psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation, Parkinson's disease, and dyskinesias, infections such as bacterial, fungal, protozoan and viral infections; pain; eating disorders, such as obesity, anorexia, and bulimia; asthma; urinary retention; oteoporosis; allergies; Huntington's disease or Gilles de la Tourette's syndrome, among others and diagnostic assays for such conditions.
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公开(公告)号：EP1226435A1
公开(公告)日：2002-07-31
申请号：EP00973867.5
申请日：2000-10-26
发明人： AUBART, Kelly, M. , BERGSMA, Derk, J. , FITZGERALD, Laura, R. , GRAYBILL, Todd, L. , LI, Xiaotong , Michalovich, David , MORROW, Dwight, M. , ZHU, Yuan
IPC分类号： G01N33/53 , G01N33/567 , C12P21/06 , C12P21/04 , C12N1/20 , C12N15/00 , C12N15/09 , C12N15/63 , C12N15/70 , C12N15/74 , C12N5/00 , C12N5/02 , A01N37/18 , A61K38/00 , C07K14/00 , C07K16/00 , C07K17/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00
CPC分类号： C07D233/64 , A61K38/00 , C07B2200/11 , C07D403/12 , C07K14/705
摘要： AXOR35 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing AXOR35 polypeptides and polynucleotides in diagnostic assays.
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公开(公告)号：EP1070080A1
公开(公告)日：2001-01-24
申请号：EP99912266.6
申请日：1999-03-04
申请人： SMITHKLINE BEECHAM CORPORATION , SB laboratoires Pharmaceutiques , SMITHKLINE BEECHAM PLC , Stadel, Pamela
发明人： BERGSMA, Derk, J. , CHAMBERS, Jonathan K.,Coldharbour Road , CHAN, Winnie , JOHNSON, Randall, K. , KHANDOUDI, Nassirah , LIVI, George, P. , ROBERT, Phillippe , STADEL, Jeffrey, M. , WILSON, Shelagh,Coldharbour Road
CPC分类号： C07K14/705 , C07K14/723 , C40B40/00
摘要： Human EDG-1c polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Human EDG-1c is identified as a selective receptor for sphingosine-1-phosphate ('S-1-P') and for dihydro S-1-P. Also disclosed are methods for discovering agonists and antagonists of the interaction between S-1-P and dihydro S-1-P and their cellular receptor, human EDG-1c, which may have utility in the treatment of several human diseases and disorders, including, but not limited to the treatment of infections such as bacterial, fungal, protozoan and viral infections.
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4.发明公开METHODS OF SCREENING FOR AGONISTS AND ANTAGONISTS OF THE HDPXU17 RECEPTOR 审中-公开一种筛选HDPXU17受体激动剂和拮抗剂
公开(公告)号：EP1137938A1
公开(公告)日：2001-10-04
申请号：EP99964135.0
申请日：1999-12-07
IPC分类号： G01N33/53 , G01N33/566
CPC分类号： G01N33/566 , G01N2333/726 , G01N2500/20
摘要： An isolated polynucleotide encoding a human PY purinergic receptor and the protein encoded thereby are disclosed. Also disclosed is an assay for identifiying agonists and antagonists of the disclosed receptor.
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公开(公告)号：EP1007563A1
公开(公告)日：2000-06-14
申请号：EP98930215.3
申请日：1998-06-12
发明人： ELSHOURBAGY, Nabil, A. , LI, Xiaotong , BERGSMA, Derk, J. , MOONEY, Jeffrey, L. , GUERRERA, Stephanie, F.
IPC分类号： C07K14/705 , C07K16/28 , C12N15/12
CPC分类号： C07K14/705
摘要： HM74A polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HM74A polypeptides and polynucleotides in therapy, and diagnostic assays for such.
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公开(公告)号：EP0859787B1
公开(公告)日：2001-10-10
申请号：EP96926106.4
申请日：1996-07-22
IPC分类号： C12N15/12 , C07K14/705 , C12N15/70 , C12N15/86 , C12N1/21 , C12N5/10 , C07K16/28 , A61K38/17 , A61K48/00 , G01N33/566
CPC分类号： G01N33/68 , A61K38/00 , A61K48/00 , C07K14/705 , C12N2799/026 , G01N2333/726 , G01N2500/00
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公开(公告)号：EP0988313A1
公开(公告)日：2000-03-29
申请号：EP98925271.3
申请日：1998-06-04
CPC分类号： C12N15/1096
摘要： The present invention provides a method for high throughput cloning of full length cDNA sequences. This method uses a plurality of clone arrays prepared from cDNA libraries which have been preferably enriched for 5' mRNA sequences and size fractionated into several discrete ranges (sub-libraries). These arrays are used to rapidly identify the full length cDNA sequence for a DNA segment of interest.
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公开(公告)号：EP1158856A1
公开(公告)日：2001-12-05
申请号：EP00911971.0
申请日：2000-02-25
发明人： BERGSMA, Derk, J. , CHAPMAN, Conrad , DEPIERA, Megan, E. , ELLIS, Catherine, E. , LONSDALE, John , MOONEY, Jeffrey, L.
CPC分类号： C12N9/1029 , A61K38/00 , A61K48/00 , C12Q1/25 , G01N2500/20
摘要： Fatty Acid Synthase polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilising Fatty Acid Synthase polypeptides and polynucleotides in therapy, and diagnostic assays for such.
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公开(公告)号：EP1071708A1
公开(公告)日：2001-01-31
申请号：EP99918524.2
申请日：1999-04-14
发明人： BERGSMA, Derk, J. , ELSHOURBAGY, Nabil , LANE, Pamela , LI, Xiaotong , MOONEY, Jeffrey, L. , TSUI, Ping
IPC分类号： C07K14/435 , C07K14/47 , C07K14/705 , C12N5/10 , C12N15/85 , G01N33/53 , G01N33/566
CPC分类号： C07K14/723 , A61K38/00
摘要： Human H218 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Human H218 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
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公开(公告)号：EP0859787A1
公开(公告)日：1998-08-26
申请号：EP96926106.0
申请日：1996-07-22
IPC分类号： G01N33 , A61K31 , A61K38 , A61K39 , A61K45 , A61P9 , A61P11 , A61P13 , A61P25 , A61P29 , A61P31 , A61P37 , A61P43 , C07K14 , C07K16 , C12N1 , C12N5 , C12N15 , C12P21 , C12Q1 , A61K48 , C12R1
CPC分类号： G01N33/68 , A61K38/00 , A61K48/00 , C07K14/705 , C12N2799/026 , G01N2333/726 , G01N2500/00
摘要： Human G-Protein Coupled Receptor HNFDS78 polypeptides and DNA (RNA) encoding such G-Protein Coupled Receptor HNFDS78 and a procedure for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing such G-Protein Coupled Receptor HNFDS78 for the treatment of diseases, such as atherosclerosis, inflammatory disease, and infectious disease. Antagonists against such G-Protein Coupled Receptor HNFDS78 and their use as a therapeutic to treat disease are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding G-protein coupled receptors and for detecting altered levels of the polypeptide in a host.
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