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公开(公告)号：EP0107486A1
公开(公告)日：1984-05-02
申请号：EP83306384.5
申请日：1983-10-20
发明人： Ishizumi, Kikuo , Ohashi, Naohito , Tanno, Norihiko , Sato, Hiromi , Fukui, Masaru , Morisada, Shinya
IPC分类号： C07H15/252 , C07H15/24 , A61K31/70 , C07C97/18 , C07C103/42 , C07D413/04
CPC分类号： C07D413/04 , C07H15/252
摘要： 9-Aminonaphthacene derivative having the formula:
wherein R 1 and R 2 are both hydrogen atoms or either one of them is a hydrogen atom and the other is hydroxy group or methoxy group; R 3 is acetyl group or 1-hydroxyethyl group; R 4 is a hydrogen atom or halogen-substituted lower alkanoyl group; R 5 is a hydrogen atom, hydroxy group, lower alkanoyloxy group, amino group, halogen-substituted lower alkanoylamino group or morpholino group; R 6 is a hydrogen atom, hydroxy group, lower alkanoyloxy group or tetrahdropyranyl- oxy group; R' is a hydrogen atom, methyl group, hydroxymethyl group or lower alkanoyloxymethyl group; R is a hydrogen atom, hydroxy group or lower alkanoyloxy group, and n is zero or one, which is useful as anti-cancer chemical agents with lower toxicity.-
2.发明公开Antitumor substance and composition, and process for preparing said substance 失效防腐剂物质和组合物，以及制备物质的方法
公开(公告)号：EP0024206A3
公开(公告)日：1981-11-25
申请号：EP80302813
申请日：1980-08-14
发明人： Yoshida, Noboru , Kiyohara, Takao , Fukui, Masaru , Fukui, Akio , Ogino, Shigeo , Inaba, Makoto , Tsukagoshi, Shigeru , Sakurai, Yoshio
CPC分类号： C07K14/212 , A61K38/00
摘要： The toxicity of a known antitumor substance prepared by culturing a microorganism, Acinetobacter calcoaceticus var. microformis SC-1714 is reduced by treatment with barium hydroxide and isolating an antitumor substance having an excellent antitumor activity as well as a potent immunostimulatory activity. The novel substance is effective when administered in very small amounts without harmful effects such as toxicity.
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公开(公告)号：EP0107486B1
公开(公告)日：1987-04-29
申请号：EP83306384.5
申请日：1983-10-20
发明人： Ishizumi, Kikuo , Ohashi, Naohito , Tanno, Norihiko , Sato, Hiromi , Fukui, Masaru , Morisada, Shinya
IPC分类号： C07H15/252 , C07H15/24 , A61K31/70 , C07C97/18 , C07C103/42 , C07D413/04
CPC分类号： C07D413/04 , C07H15/252
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4.发明公开Antitumor substance, composition comprising it and process for preparing said substance 失效抗肿瘤物质，该组合物含有，使该物质的方法。
公开(公告)号：EP0024206A2
公开(公告)日：1981-02-25
申请号：EP80302813.3
申请日：1980-08-14
发明人： Yoshida, Noboru , Kiyohara, Takao , Fukui, Masaru , Fukui, Akio , Ogino, Shigeo , Inaba, Makoto , Tsukagoshi, Shigeru , Sakurai, Yoshio
CPC分类号： C07K14/212 , A61K38/00
摘要： The toxicity of a known antitumor substance prepared by culturing a microorganism, Acinetobacter calcoaceticus var. microformis SC-1714 is reduced by treatment with barium hydroxide and isolating an antitumor substance having an excellent antitumor activity as well as a potent immunostimulatory activity. The novel substance is effective when administered in very small amounts without harmful effects such as toxicity.
摘要翻译： 通过培养微生物而制备的公知的抗肿瘤物质的毒性，不动杆菌变种Microformis SC-1714是通过用氢氧化并具有优异的抗肿瘤活性的抗肿瘤物质的隔离钡以及强效免疫刺激活性治疗减少。 该新物质是有效的，当在非常小的量施用无有害作用：如毒性。
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