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    Aminonaphthacene derivatives and their production
    4.
    发明公开
    Aminonaphthacene derivatives and their production 失效
    氨基苯甲酸衍生物及其生产

    公开(公告)号：EP0071483A3

    公开(公告)日：1983-03-09

    申请号：EP82304021

    申请日：1982-07-29

    申请人： SUMITOMO CHEMICAL COMPANY, LIMITED

    发明人： Ishizumi, Kikuo ,  Muramatsu, Michihisa ,  Sato, Hiromi ,  Yoshida, Noboru

    IPC分类号： C07C97/18 ,  C07D317/28 ,  A61K31/135 ,  A61K31/335

    CPC分类号： C07D317/28

    摘要： Aminonaphthacene derivatives of the formula:
    wherein R 1 is a hydrogen atom, a hydroxyl group or a lower alkoxy group, R 2 is a hydrogen atom or a hydroxyl group, R 3 and R 4 are each a lower alkyl group or, when taken together, represent an ethylenedioxy group or an oxo group and R 6 and R 8 are each a hydrogen atom, a lower alkyl group or a group of the formula: -A-Q (in which A is an alkylene group optionally bearing at least one lower alkyl and Q is a hydrogen atom, a hydroxyl group, a lower alkoxy group or a group of the formula:
    wherein R 7 and R 8 are each a hydrogen atom, a lower alkyl group, a benzyl group, a hydroxy (lower) alkyl group or an amino (lower) alkyl group or, when taken together with the adjacent nitrogen atom to which they are attached, represent a 5 to 7-membered nitrogen-containing ring optionally having an additional nitrogen or oxygen atom in the ring and optionally bearing any substituent on the ring) or, R 5 and R 6 when taken together with the adjacent nitrogen atom to which they are attached, represent a 5 to 7-membered nitrogen-containing ring optionally having an additional nitrogen or oxygen atom in the ring and optionally bearing any substituent on the ring, and their acid addition salts, which are useful as anti-tumor agents.

    Aminonaphthacene derivatives and their production
    5.
    发明公开
    Aminonaphthacene derivatives and their production 失效
    氨基萘磺酸衍生物和Herstellung。

    公开(公告)号：EP0071483A2

    公开(公告)日：1983-02-09

    申请号：EP82304021.7

    申请日：1982-07-29

    申请人： SUMITOMO CHEMICAL COMPANY, LIMITED

    发明人： Ishizumi, Kikuo ,  Muramatsu, Michihisa ,  Sato, Hiromi ,  Yoshida, Noboru ,  Tanno, Norihiko

    IPC分类号： C07C97/18 ,  C07D317/28

    CPC分类号： C07D317/28

    摘要： Aminonaphthacene derivatives of the formula:
    wherein R 1 is a hydrogen atom, a hydroxyl group or a lower alkoxy group, R 2 is a hydrogen atom or a hydroxyl group, R 3 and R 4 are each a lower alkyl group or, when taken together, represent an ethylenedioxy group or an oxo group and R 6 and R 8 are each a hydrogen atom, a lower alkyl group or a group of the formula: -A-Q (in which A is an alkylene group optionally bearing at least one lower alkyl and Q is a hydrogen atom, a hydroxyl group, a lower alkoxy group or a group of the formula:
    wherein R 7 and R 8 are each a hydrogen atom, a lower alkyl group, a benzyl group, a hydroxy (lower) alkyl group or an amino (lower) alkyl group or, when taken together with the adjacent nitrogen atom to which they are attached, represent a 5 to 7-membered nitrogen-containing ring optionally having an additional nitrogen or oxygen atom in the ring and optionally bearing any substituent on the ring) or, R 5 and R 6 when taken together with the adjacent nitrogen atom to which they are attached, represent a 5 to 7-membered nitrogen-containing ring optionally having an additional nitrogen or oxygen atom in the ring and optionally bearing any substituent on the ring, and their acid addition salts, which are useful as anti-tumor agents.

    摘要翻译： 其中R 1为氢原子，羟基或低级烷氧基，R 2为氢原子或羟基，R 3和R 4为氢， 4>各自为低级烷基，或者一起表示亚乙二氧基或氧代基，R 5和R 6各自为氢原子，低级烷基或下式基团： - AQ（其中A是任选带有至少一个低级烷基的亚烷基，Q是氢原子，羟基，低级烷氧基或下式的基团：... 其中R 7和R 8是氢原子，低级烷基，苄基，羟基（低级）烷基或氨基（低级）烷基，当与它们所连接的相邻氮原子一起代表 5至7元含氮环，任选在环中具有额外的氮原子或氧原子，并且任选在环上带有任何取代基）或R 5和R 6当 与它们所连接的相邻氮原子一起代表在环中任选具有额外的氮或氧原子且任选地在环上具有任何取代基的5至7元含氮环，及其酸加成盐， 其可用作抗肿瘤剂。