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公开(公告)号:EP3191483A4
公开(公告)日:2018-04-18
申请号:EP15840696
申请日:2015-09-11
发明人: ZHANG YINGJUN , YU TIANZHU , LIU BING , ZHANG XIANGYU , ZHANG SHIGUO , CHENG CHANGCHUNG , ZHANG JIANCUN
IPC分类号: C07D471/04 , A61K31/405 , A61P43/00 , C07D209/14 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12
CPC分类号: C07D209/14 , A61K31/405 , A61K31/4375 , A61K31/454 , A61K31/4709 , A61K31/498 , A61K45/06 , C07B2200/13 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D471/04
摘要: The compounds of Formula (I) which can be used as CRTH2 receptor antagonists are provided. The compounds of Formula (I) can be used in the treatment and prevention of asthma, allergic rhinitis and atopic dermatitis, as well as other diseases mediated by prostaglandin D2 (PGD2) at the CRTH2 receptor.
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公开(公告)号:EP3256468A4
公开(公告)日:2018-07-25
申请号:EP16748725
申请日:2016-02-05
发明人: WANG XIAOJUN , YANG XINYE , PAN SHENGQIANG , GUO RUI , WU JUNWEN , ZHANG YINGJUN , CHENG CHANGCHUNG
IPC分类号: C07D413/12 , A61K31/42 , A61K31/4353 , A61K31/4985 , A61K31/519 , C07D249/06 , C07D261/08 , C07D411/12 , C07D471/04 , C07D491/044 , C07D491/052 , C07D491/147 , C07D497/04 , C07D498/04 , C07D498/14
CPC分类号: C07D261/08 , A61K31/42 , A61K31/4353 , A61K31/4985 , A61K31/519 , C07D249/06 , C07D411/12 , C07D413/12 , C07D471/04 , C07D491/044 , C07D491/052 , C07D491/147 , C07D497/04 , C07D498/04 , C07D498/14
摘要: The present invention relates to novel tricyclic compounds which can bind to FXR and act as modulators of the FXR, or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, and the uses of the compounds for the treatment of diseases and/or conditions mediated by FXR. The invention further provides a pharmaceutical composition containing the compound disclosed herein and a method of treatment of diseases and/or conditions mediated by FXR comprising administering the compound or the pharmaceutical composition.
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公开(公告)号:EP3169671A4
公开(公告)日:2018-02-28
申请号:EP15822879
申请日:2015-07-16
发明人: CHENG CHANGCHUNG , ZHANG YINGJUN , LIU BING , LONG BOHUA , CHEN YU , CHENG ZHIXIN
IPC分类号: C07D261/14 , A61K31/422 , A61K31/437 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/541 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/056 , C07D491/08 , C07D491/107 , C07D513/04 , C07D513/14 , C07D519/00
CPC分类号: C07D261/14 , A61K31/422 , A61K31/437 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5025 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/056 , C07D491/08 , C07D491/107 , C07D513/04 , C07D513/14 , C07D519/00 , A61K2300/00
摘要: Provided herein are novel substituted urea derivatives, and pharmaceutical compositions thereof. Also provided herein are uses of the compounds or pharmaceutical compositions thereof for preventing, managing, treating or lessening a proliferative disease, and modulating the activity of protein kinase.
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4.
公开(公告)号:EP3172214A4
公开(公告)日:2018-02-07
申请号:EP15828004
申请日:2015-07-23
发明人: LIU BING , ZHANG YINGJUN , NIE LINLIN , BAI SHUN , GUAN MINGYU , LI XUKE , CHENG CHANGCHUNG
IPC分类号: C07D519/00 , A61K31/519 , A61K31/5377 , A61K31/5383 , A61P29/00 , A61P35/00 , A61P37/00 , C07D471/04
CPC分类号: C07D471/04 , A61K31/519 , A61K31/5377 , A61K31/5383 , A61K45/06 , C07D519/00 , A61K2300/00
摘要: The invention provides compounds as CDK small-molecule inhibitors and uses thereof, the compounds can be used for treating inflammation and cell proliferation diseases. The novel compound of the invention is a powerful cyclin-dependent kinase 4 (CDK 4) or cyclin-dependent kinase-6 (CDK 6) inhibitor.
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