公开(公告)号：EP1533313A4

公开(公告)日：2007-01-24

申请号：EP03738665

申请日：2003-07-03

申请人： SUNTORY LTD

发明人： ISHIKURA YOSHIYUKI ,  TSUJI KUNIRO ,  NUKAYA HARUO

IPC分类号： A23L2/38 ,  A23L1/30 ,  A23L2/52 ,  A61K8/00 ,  A61K8/06 ,  A61K8/49 ,  A61K31/352 ,  A61P11/02 ,  A61P17/00 ,  A61P17/04 ,  A61P27/14 ,  A61P37/08 ,  A61P43/00 ,  A61Q1/00 ,  A61Q1/02 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q19/00 ,  A61Q19/10 ,  C07D493/14 ,  A23L2/00 ,  A61K7/00 ,  A61K7/02 ,  A61K7/06 ,  A61K7/075 ,  A61K7/48 ,  A61K7/50

CPC分类号： A61K8/602 ,  A23L33/11 ,  A23V2002/00 ,  A61K31/352 ,  A61Q5/02 ,  A61Q19/00 ,  C07D493/14 ,  A23V2200/304 ,  A23V2250/2116

摘要： It is intended to provide a novel flavone C-glycoside derivative or its salt showing, in particular, an antiallergic effect and a composition containing the same. Allergic diseases have been increasing in the recent years. Among all, pollenosis and atopic dermatitis are remarkably increasing to thereby result in social problems. Flavones and glycosides thereof, which are reported as having an effect of inhibiting the release of histamine from adipocytes and an immunosuppressive effect, are expected as being applicable as remedies for allergy. However, most of flavones should be taken in a large dose to exert the effects and, therefore, it has been urgently required to find out a compound exhibiting the effects at a smaller dose. Under these circumstances, it is intended to provide a novel component whereby allergic diseases can be treated in a small dose and a composition containing the same.

公开(公告)号：EP1731522A4

公开(公告)日：2009-05-27

申请号：EP05721621

申请日：2005-03-28

申请人： SUNTORY LTD

发明人： TSUJI KUNIRO ,  NUKAYA HARUO

IPC分类号： C07D493/14 ,  A61K31/35 ,  A61P17/00 ,  A61P37/08 ,  A61P43/00 ,  C07B53/00 ,  C07B61/00

CPC分类号： C07D493/14

摘要： It is intended to provide a process for efficiently producing a flavone C glycoside derivative represented by the formula (1) which is an antiallergic substance or its salt, or a flavone C glycoside derivative represented by the formula (4) or its salt. According to this process, the flavone C glycoside derivative represented by the formula (1) or its salt and the flavone C glycoside derivative represented by the formula (4) can be easily and efficiently synthesized by using isovitexine and vitexine contained in herbs and so on as the starting materials.

公开(公告)号：EP1516878A4

公开(公告)日：2005-08-10

申请号：EP03738516

申请日：2003-06-26

申请人： SUNTORY LTD

发明人： SUWA YOSHIHIDE ,  FUJII WATARU ,  HORI HISAKO ,  YOKOO YOSHIAKI ,  NUKAYA HARUO ,  TSUJI KUNIRO

IPC分类号： A23L1/30 ,  A61K31/343 ,  A61P1/00 ,  A61P1/14 ,  A61P13/02 ,  A61P43/00 ,  C07D307/84 ,  A23L1/28 ,  A23L2/00 ,  A61K35/72 ,  A61K35/78 ,  C12C5/00 ,  C12G3/00

CPC分类号： C07D307/84 ,  A23L33/105 ,  A61K31/343

摘要： A substance capable of stimulating the movement of digestive tract, comprising a compound of the formula: (I) (active substance α and active substance β being stereoisomers), which substance is derived from natural products and hence causes no side effects, is highly safe even when continuously used for a prolonged period of time and can be widely employed as additives to refreshments, etc.; and a refreshment containing an additive comprising the stimulating substance. In particular, a digestive tract movement stimulating substance capable of acting on muscarine M3 receptor, obtained from beer through isolation and purification, which substance is one having drinkability stimulating effect; and a composition from natural products or natural processed products, comprising the above substance. The thus provided substance or composition is used as an additive to refreshment, thereby providing a refreshment capable of stimulating the movement of digestive tract.