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公开(公告)号：EP2166085A1
公开(公告)日：2010-03-24
申请号：EP08397517.7
申请日：2008-07-16
IPC分类号： C12N5/07
CPC分类号： C12N5/0006 , A61K2035/124 , C12N5/0663 , C12N5/0665 , C12N9/1051 , C12N2501/70 , C12N2501/724 , C12P21/005
摘要： The invention is directed to a method and composition to control and modify the status of human stem cells by changing their glycosylation, in particular sialylation and fucosylation, levels in a reaction condition where divalent cations are present and cells are kept non-adherent. The invention is further directed to the stem cell population so obtained, the glycosylation of which has been specifically altered.
摘要翻译： 本发明涉及一种方法和组合物，其通过在存在二价阳离子且细胞保持不粘附的反应条件下改变其糖基化，特别是唾液酸化和岩藻糖基化水平来控制和修饰人类干细胞的状态。 本发明进一步针对如此获得的干细胞群，其糖基化被特异性地改变。
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2.发明公开Sulphated hyaluronic acid in combination with G-CSF for use in mobilising blood stem cells 审中-公开SulfatierteHyaluronsäurein Kombination mit G-CSFfürden Einsatz bei der Mobilisierung von Blutstammzellen
公开(公告)号：EP2384759A1
公开(公告)日：2011-11-09
申请号：EP10162117.5
申请日：2010-05-06
发明人： Nystedt, Johanna , Anderson, Heidi , Satomaa, Tero , Natunen, Jari , Helin, Jari , Saarinen, Juhani
IPC分类号： A61K31/728 , C07K14/535 , A61P7/00
CPC分类号： A61K31/198 , A61K31/728 , A61K38/193 , C07K14/535 , C08B37/0072 , C08L5/08 , A61K2300/00
摘要： The present invention relates to a combination of a hyaluronan oligomer and/or polymer and a factor capable of mobilizing stem cells. The present invention relates also to a use of the combination to alter the relative amounts of blood cells and/or the types of blood cells in a subject. Further, the present invention relates to a use of the combination to mobilize stem cells to the bloodstream of a subject. Additionally, the present invention relates to a hyaluronan oligomer and/or polymer.
摘要翻译： 本发明涉及透明质酸低聚物和/或聚合物的组合以及能够动员干细胞的因子。 本发明还涉及组合物用于改变受试者血细胞相对量和/或血细胞类型的用途。 此外，本发明涉及组合物用于将干细胞移动到受试者的血流中的用途。 另外，本发明涉及透明质酸低聚物和/或聚合物。
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3.发明公开Sulphated hyaluronic acid in combination with G-CSF for use in mobilising blood stem cells 审中-公开硫酸化透明质酸与G-CSF联合用于动员血液干细胞
公开(公告)号：EP2384760A1
公开(公告)日：2011-11-09
申请号：EP11165109.7
申请日：2011-05-06
发明人： Nystedt, Johanna , Anderson, Heidi , Satomaa, Tero , Natunen, Jari , Helin, Jari , Saarinen, Juhani
IPC分类号： A61K31/728 , C07K14/535 , A61P7/00
CPC分类号： A61K31/198 , A61K31/728 , A61K38/193 , C07K14/535 , C08B37/0072 , C08L5/08 , A61K2300/00
摘要： The present invention relates to a combination of a hyaluronan oligomer and/or polymer and a factor capable of mobilizing stem cells. The present invention relates also to a use of the combination to alter the relative amounts of blood cells and/or the types of blood cells in a subject. Further, the present invention relates to a use of the combination to mobilize stem cells to the bloodstream of a subject. Additionally, the present invention relates to a hyaluronan oligomer and/or polymer.
摘要翻译： 本发明涉及乙酰透明质酸寡聚物和/或聚合物与能够动员干细胞的因子的组合。 本发明还涉及所述组合的用途，以改变受试者血细胞和/或血细胞类型的相对量。 此外，本发明涉及该组合将干细胞移植到受试者血流中的用途。 另外，本发明涉及乙酰透明质酸寡聚物和/或聚合物。
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