-
1.发明公开Sulphated hyaluronic acid in combination with G-CSF for use in mobilising blood stem cells 审中-公开SulfatierteHyaluronsäurein Kombination mit G-CSFfürden Einsatz bei der Mobilisierung von Blutstammzellen
公开(公告)号：EP2384759A1
公开(公告)日：2011-11-09
申请号：EP10162117.5
申请日：2010-05-06
发明人： Nystedt, Johanna , Anderson, Heidi , Satomaa, Tero , Natunen, Jari , Helin, Jari , Saarinen, Juhani
IPC分类号： A61K31/728 , C07K14/535 , A61P7/00
CPC分类号： A61K31/198 , A61K31/728 , A61K38/193 , C07K14/535 , C08B37/0072 , C08L5/08 , A61K2300/00
摘要： The present invention relates to a combination of a hyaluronan oligomer and/or polymer and a factor capable of mobilizing stem cells. The present invention relates also to a use of the combination to alter the relative amounts of blood cells and/or the types of blood cells in a subject. Further, the present invention relates to a use of the combination to mobilize stem cells to the bloodstream of a subject. Additionally, the present invention relates to a hyaluronan oligomer and/or polymer.
摘要翻译： 本发明涉及透明质酸低聚物和/或聚合物的组合以及能够动员干细胞的因子。 本发明还涉及组合物用于改变受试者血细胞相对量和/或血细胞类型的用途。 此外，本发明涉及组合物用于将干细胞移动到受试者的血流中的用途。 另外，本发明涉及透明质酸低聚物和/或聚合物。
-
2.发明公开Sulphated hyaluronic acid in combination with G-CSF for use in mobilising blood stem cells 审中-公开硫酸化透明质酸与G-CSF联合用于动员血液干细胞
公开(公告)号：EP2384760A1
公开(公告)日：2011-11-09
申请号：EP11165109.7
申请日：2011-05-06
发明人： Nystedt, Johanna , Anderson, Heidi , Satomaa, Tero , Natunen, Jari , Helin, Jari , Saarinen, Juhani
IPC分类号： A61K31/728 , C07K14/535 , A61P7/00
CPC分类号： A61K31/198 , A61K31/728 , A61K38/193 , C07K14/535 , C08B37/0072 , C08L5/08 , A61K2300/00
摘要： The present invention relates to a combination of a hyaluronan oligomer and/or polymer and a factor capable of mobilizing stem cells. The present invention relates also to a use of the combination to alter the relative amounts of blood cells and/or the types of blood cells in a subject. Further, the present invention relates to a use of the combination to mobilize stem cells to the bloodstream of a subject. Additionally, the present invention relates to a hyaluronan oligomer and/or polymer.
摘要翻译： 本发明涉及乙酰透明质酸寡聚物和/或聚合物与能够动员干细胞的因子的组合。 本发明还涉及所述组合的用途，以改变受试者血细胞和/或血细胞类型的相对量。 此外，本发明涉及该组合将干细胞移植到受试者血流中的用途。 另外，本发明涉及乙酰透明质酸寡聚物和/或聚合物。
-
公开(公告)号：EP2166085A1
公开(公告)日：2010-03-24
申请号：EP08397517.7
申请日：2008-07-16
IPC分类号： C12N5/07
CPC分类号： C12N5/0006 , A61K2035/124 , C12N5/0663 , C12N5/0665 , C12N9/1051 , C12N2501/70 , C12N2501/724 , C12P21/005
摘要： The invention is directed to a method and composition to control and modify the status of human stem cells by changing their glycosylation, in particular sialylation and fucosylation, levels in a reaction condition where divalent cations are present and cells are kept non-adherent. The invention is further directed to the stem cell population so obtained, the glycosylation of which has been specifically altered.
摘要翻译： 本发明涉及一种方法和组合物，其通过在存在二价阳离子且细胞保持不粘附的反应条件下改变其糖基化，特别是唾液酸化和岩藻糖基化水平来控制和修饰人类干细胞的状态。 本发明进一步针对如此获得的干细胞群，其糖基化被特异性地改变。
-
公开(公告)号：EP2431743A3
公开(公告)日：2012-07-18
申请号：EP11189389.7
申请日：2006-07-20
申请人： Glykos Finland Oy
发明人： Satomaa, Tero , Natunen, Jari , Heiskanen, Annamari , Olonen, Anne , Saarinen, Juhani , Salovuori, Noora , Helin, Jari
IPC分类号： G01N33/574 , A61K31/715
CPC分类号： C07K16/44 , C07K2317/21 , C07K2317/24 , C07K2317/76 , C12Q1/34 , G01N33/574 , G01N33/57488 , G01N33/57492 , G01N2400/38 , Y10T436/143333
摘要： The present invention describes glycans, which are specifically expressed by certain cancer cells, tumours and other malignant tissues. The present invention describes methods to detect cancer specific glycans as well as methods for the production of reagents binding to said glycans. The invention is also directed to the use of said glycans and reagents binding to them for the diagnostics of cancer and malignancies. Furthermore, the invention is directed to the use of said glycans and reagents binding to them for the treatment of cancer and malignancies. Moreover, the present invention comprises efficient methods to differentiate between malignant and benign tumors by analyzing glycan structures.
摘要翻译： 本发明描述了由某些癌细胞，肿瘤和其它恶性组织特异性表达的聚糖。 本发明描述了检测癌症特异性聚糖的方法以及生产结合所述聚糖的试剂的方法。 本发明还涉及所述聚糖和与其结合的试剂用于诊断癌症和恶性肿瘤的用途。 此外，本发明涉及所述聚糖和与其结合的试剂用于治疗癌症和恶性肿瘤的用途。 此外，本发明包括通过分析聚糖结构来区分恶性和良性肿瘤的有效方法。
-
公开(公告)号：EP2322209A2
公开(公告)日：2011-05-18
申请号：EP10184228.4
申请日：2003-08-20
申请人： Glykos Finland Oy
CPC分类号： A61K39/39558 , A61K38/1709 , A61K38/45 , A61K39/00 , A61K47/549 , A61K47/6851 , A61K2039/505 , C07H3/06 , C07K16/18 , C12Y204/00 , G01N33/57469 , G01N33/57492
摘要： The present invention describes oligosaccharide sequences, which are specifically expressed by human tumors. The present invention is related to a method of determining an oligosaccharide sequence, which comprises a tumor specific terminal N-acetylglucosamine residue, in a biological sample, the presence of said sequence in said sample being an indication of the presence of cancer. The present invention provides antigenic substances comprising said oligosaccharide sequences in a polyvalent form and it further provides diagnostic agents, pharmaceutical compositions and cancer vaccines comprising said oligosaccharide sequences or substances binding to said oligosaccharide sequences. The present invention is also related to methods for the treatment of cancer.
摘要翻译： 本发明描述了由人肿瘤特异性表达的寡糖序列。 本发明涉及在生物样品中测定包含肿瘤特异性末端N-乙酰葡糖胺残基的寡糖序列的方法，所述样品中所述序列的存在是癌症存在的指示。 本发明提供包含多价形式的所述寡糖序列的抗原物质，并且还提供包含所述寡糖序列或与所述寡糖序列结合的物质的诊断试剂，药物组合物和癌症疫苗。 本发明还涉及治疗癌症的方法。
-
公开(公告)号：EP2431743B1
公开(公告)日：2018-05-30
申请号：EP11189389.7
申请日：2006-07-20
申请人： Glykos Finland Oy
发明人： Satomaa, Tero , Natunen, Jari , Heiskanen, Annamari , Olonen, Anne , Saarinen, Juhani , Salovuori, Noora , Helin, Jari
IPC分类号： G01N33/574 , A61K31/715
CPC分类号： C07K16/44 , C07K2317/21 , C07K2317/24 , C07K2317/76 , C12Q1/34 , G01N33/574 , G01N33/57488 , G01N33/57492 , G01N2400/38 , Y10T436/143333
摘要： The present invention describes glycans, which are specifically expressed by certain cancer cells, tumours and other malignant tissues. The present invention describes methods to detect cancer specific glycans as well as methods for the production of reagents binding to said glycans. The invention is also directed to the use of said glycans and reagents binding to them for the diagnostics of cancer and malignancies. Furthermore, the invention is directed to the use of said glycans and reagents binding to them for the treatment of cancer and malignancies. Moreover, the present invention comprises efficient methods to differentiate between malignant and benign tumors by analyzing glycan structures.
-
公开(公告)号：EP2322209A3
公开(公告)日：2012-02-01
申请号：EP10184228.4
申请日：2003-08-20
申请人： Glykos Finland Oy
CPC分类号： A61K39/39558 , A61K38/1709 , A61K38/45 , A61K39/00 , A61K47/549 , A61K47/6851 , A61K2039/505 , C07H3/06 , C07K16/18 , C12Y204/00 , G01N33/57469 , G01N33/57492
摘要： The present invention describes oligosaccharide sequences, which are specifically expressed by human tumors. The present invention is related to a method of determining an oligosaccharide sequence, which comprises a tumor specific terminal N-acetylglucosamine residue, in a biological sample, the presence of said sequence in said sample being an indication of the presence of cancer. The present invention provides antigenic substances comprising said oligosaccharide sequences in a polyvalent form and it further provides diagnostic agents, pharmaceutical compositions and cancer vaccines comprising said oligosaccharide sequences or substances binding to said oligosaccharide sequences. The present invention is also related to methods for the treatment of cancer.
-
8.发明公开
公开(公告)号：EP2272522A2
公开(公告)日：2011-01-12
申请号：EP09157883.1
申请日：2003-06-30
申请人： Glykos Finland Oy
发明人： Angström, Jonas , Teneberg, Susann , Saarinen, Juhani , Satomaa, Tero , Roche, Niamh , Natunen, Jari , Miller-Podraza, Halina , Karlsson, Karl-Anders , Abul-Milh, Maan
IPC分类号： A61K31/702 , A61K35/00 , A61P1/12
CPC分类号： G01N33/56922 , A23L33/10 , A23L33/40 , A23V2002/00 , A61K31/702 , A61K45/06 , A61K47/61 , G01N33/566 , G01N33/56905 , G01N33/56911 , G01N33/56916 , Y02A50/473 , Y02A50/475 , A61K2300/00 , A23V2250/28 , A23V2200/32
摘要： The invention provides a therapeutical composition comprising purified fractions of compounds being or containing a pathogen-inhibiting oligosaccharide sequence for use as a medicament. The present invention especially describes an oligosaccharide-containing substance or receptor binding to diarrheagenic Escherichia coli and/or zoonotic Helicobacter species, and use thereof in, e.g., pharmaceutical, nutritional and other compositions for prophylaxis and treatment of conditions due to the presence of Escherichia coli and/or zoonotic Helicobacter species. The invention is also directed to the use of the receptors for diagnostics of Escherichia coli and/or zoonotic Helicobacter species.
摘要翻译： 本发明提供一种治疗组合物，包括化合物的纯化馏分是或含有用作药物的病原体 - 抑制寡糖序列。 本发明的爱特别描述物质或受体结合到致泻大肠杆菌和/或人畜共患螺杆菌种到含低聚糖，而在它们的使用，例如，药物，由于大肠杆菌的存在营养和其他的组合物用于预防和治疗的条件 和/或人畜共患螺杆菌种。 因此，本发明涉及使用所述受体的大肠杆菌和/或人畜共患螺杆菌种的诊断。
-
公开(公告)号：EP2431743A2
公开(公告)日：2012-03-21
申请号：EP11189389.7
申请日：2006-07-20
申请人： Glykos Finland Oy
发明人： Satomaa, Tero , Natunen, Jari , Heiskanen, Annamari , Olonen, Anne , Saarinen, Juhani , Salovuori, Noora , Helin, Jari
IPC分类号： G01N33/574 , A61K31/715
CPC分类号： C07K16/44 , C07K2317/21 , C07K2317/24 , C07K2317/76 , C12Q1/34 , G01N33/574 , G01N33/57488 , G01N33/57492 , G01N2400/38 , Y10T436/143333
摘要： The present invention describes glycans, which are specifically expressed by certain cancer cells, tumours and other malignant tissues. The present invention describes methods to detect cancer specific glycans as well as methods for the production of reagents binding to said glycans. The invention is also directed to the use of said glycans and reagents binding to them for the diagnostics of cancer and malignancies. Furthermore, the invention is directed to the use of said glycans and reagents binding to them for the treatment of cancer and malignancies. Moreover, the present invention comprises efficient methods to differentiate between malignant and benign tumors by analyzing glycan structures.
摘要翻译： 本发明描述了由某些癌细胞，肿瘤和其他恶性组织特异性表达的聚糖。 本发明描述了检测癌症特异性聚糖的方法以及用于产生与所述聚糖结合的试剂的方法。 本发明还涉及所述聚糖和与其结合的试剂用于癌症和恶性肿瘤的诊断的用途。 此外，本发明涉及所述聚糖和与其结合的试剂用于治疗癌症和恶性肿瘤的用途。 此外，本发明包括通过分析聚糖结构来区分恶性和良性肿瘤的有效方法。
-
公开(公告)号：EP2272522A3
公开(公告)日：2011-04-20
申请号：EP09157883.1
申请日：2003-06-30
申请人： Glykos Finland Oy
发明人： Angström, Jonas , Teneberg, Susann , Saarinen, Juhani , Satomaa, Tero , Roche, Niamh , Natunen, Jari , Miller-Podraza, Halina , Karlsson, Karl-Anders , Abul-Milh, Maan
IPC分类号： A61K31/702 , A61K35/00 , A61P1/12
CPC分类号： G01N33/56922 , A23L33/10 , A23L33/40 , A23V2002/00 , A61K31/702 , A61K45/06 , A61K47/61 , G01N33/566 , G01N33/56905 , G01N33/56911 , G01N33/56916 , Y02A50/473 , Y02A50/475 , A61K2300/00 , A23V2250/28 , A23V2200/32
摘要： The invention provides a therapeutical composition comprising purified fractions of compounds being or containing a pathogen-inhibiting oligosaccharide sequence for use as a medicament. The present invention especially describes an oligosaccharide-containing substance or receptor binding to diarrheagenic Escherichia coli and/or zoonotic Helicobacter species, and use thereof in, e.g., pharmaceutical, nutritional and other compositions for prophylaxis and treatment of conditions due to the presence of Escherichia coli and/or zoonotic Helicobacter species. The invention is also directed to the use of the receptors for diagnostics of Escherichia coli and/or zoonotic Helicobacter species.
-
-
-
-
-
-
-
-
-
搜索结果
10 条记录 (耗时 0.024 秒)
